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Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma

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Abstract

The present study was designed to determine whether the expression of chemokine receptor CXCR4 and vascular endothelial growth factor (VEGF) is correlated with the extent of metastasis and the survival of patients with osteosarcoma. Using tissue microarrays, we analyzed the expression of CXCR4 and VEGF in tumor tissues collected from 56 patients with osteosarcoma. A two-year follow-up was performed to evaluate tumor metastatic behavior and the overall survival of the patients. There was a significant correlation between the expression of CXCR4 and the expression of VEGF in tumor tissues of these patients (P = 0.002). Univariate analysis revealed that expression of these proteins was correlated with clinical stage, but not age, gender, or serum alkaline phosphatase levels. The patients with tumors expressing CXCR4 and VEGF had worse overall survival rates compared with the patients with tumors that did not express CXCR4 (P = 0.03) or VEGF (P = 0.04). These data indicate that CXCR4 and VEGF expression is highly correlated with metastatic progression in patients with osteosarcoma and had predictive value for the metastasis and survival of osteosarcoma patients.

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Acknowledgments

This work was supported by the fund of Science and Technology Commission of Shanghai R & D projects (064119637).

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Authors and Affiliations

  1. Department of Oncology, Affiliated 6th People’s Hospital, Shanghai Jiao Tong University, No 600 Yishan Road, 200223, Shanghai, People’s Republic of China

    Feng Lin, Shui-er Zheng, Zan Shen, Li-na Tang, Ping Chen, Yuan-jue Sun, Hui Zhao & Yang Yao

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  1. Feng Lin
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  2. Shui-er Zheng
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  3. Zan Shen
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  4. Li-na Tang
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  5. Ping Chen
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  6. Yuan-jue Sun
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  7. Hui Zhao
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  8. Yang Yao
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Correspondence to Yang Yao.

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Lin, F., Zheng, Se., Shen, Z. et al. Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. Med Oncol 28, 649–653 (2011). https://doi.org/10.1007/s12032-010-9493-4

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  • DOI: https://doi.org/10.1007/s12032-010-9493-4

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