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Virus Maturation

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Structure and Physics of Viruses

Part of the book series: Subcellular Biochemistry ((SCBI,volume 68))

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Abstract

The formation of infectious virus particles is a highly complex process involving a series of sophisticated molecular events. In most cases, the assembly of virus structural elements results in the formation of immature virus particles unable to initiate a productive infection. Accordingly, for most viruses the final stage of the assembly pathway entails a set of structural transitions and/or biochemical modifications that transform inert precursor particles into fully infectious agents. In this chapter, we review the most relevant maturation mechanisms involved in the generation of infectious virions for a wide variety of viruses.

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Abbreviations

3D:

Three dimensional.

AcMNPV:

Autographa californica nucleopolyhedrovirus

CA:

Capsid protein of HIV

DNA:

Deoxyribonucleic acid

ER:

Endoplasmic reticulum

ESCRT:

Endosomal sorting complexes required for transport

gp:

Glycoprotein

HA:

Hemagglutinin

HB-sAg:

HBV surface antigen

HBV:

Hepatitis B virus

HIV-1:

Human immunodeficiency virus type 1

HSV-1:

Herpes simplex virus type 1

IAV:

Influenza A virus

kbp:

Kilobase pairs

MA:

Matrix protein of HIV

NC:

Nucleocapsid protein of HIV

NωV:

Nudaurelia capensis ω virus

ORF:

Open reading frame

PR:

Protease of HIV

RNA:

Ribonucleic acid

T:

Triangulation number

VLP:

Virus-like particle

VP:

Virus protein

WNPV:

Wiseana nucleopolyhedrovirus

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Further Reading

  • References [8, 13, 21, 24, 35, 41, 42, 43, and 47] listed above are especially recommended for further reading.

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Acknowledgements

We thank Dolores Rodríguez and Ana Oña for critical readings of the manuscript. This work was supported by grant from the Spanish Ministry of Economy and Competitiveness AGL2011-24758 to JFR.

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Authors and Affiliations

  1. Laboratorio de Biología Celular y Molecular, Instituto de Histología y Embriología Mendoza (IHEM), Facultad de Ciencias Médicas, Instituto de Ciencias Básicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    Laura R. Delgui

  2. Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CSIC), c/Darwin 3, Campus de Cantoblanco, 28049, Madrid, Spain

    José F. Rodríguez

Authors
  1. Laura R. Delgui
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  2. José F. Rodríguez
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Correspondence to José F. Rodríguez .

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Editors and Affiliations

  1. "Severo Ochoa" (CSIC_UAM), And Dept. of Molecular Biology, Centro de Biología Molecular, Cantoblanco, Madrid, 28049, Madrid, Spain

    Mauricio G. Mateu

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Delgui, L.R., Rodríguez, J.F. (2013). Virus Maturation. In: Mateu, M. (eds) Structure and Physics of Viruses. Subcellular Biochemistry, vol 68. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6552-8_13

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