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Cardiolipin-Mediated Cellular Signaling

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Lipid-mediated Protein Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 991))

Abstract

This review focuses on recent studies showing that cardiolipin (CL), a unique mitochondrial phospholipid, regulates many cellular functions and signaling pathways, both inside and outside the mitochondria. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates signaling events related to apoptosis and aging. CL deficiency causes perturbation of signaling pathways outside the mitochondria, including the PKC-Slt2 cell integrity pathway and the high osmolarity glycerol (HOG) pathway, and is a key player in the cross-talk between the mitochondria and the vacuole. Understanding these connections may shed light on the pathology of Barth syndrome, a disorder of CL remodeling.

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Acknowledgements

The Greenberg laboratory acknowledges support from the National Institutes of Health (R21 HL 084218) and the Barth Syndrome Foundation (BSF) to M.L.G., and Wayne State University Graduate Enhancement Research Funds to V.A.P.

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    Vinay A. Patil & Miriam L. Greenberg

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    Daniel G.S. Capelluto

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Patil, V.A., Greenberg, M.L. (2013). Cardiolipin-Mediated Cellular Signaling. In: Capelluto, D. (eds) Lipid-mediated Protein Signaling. Advances in Experimental Medicine and Biology, vol 991. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6331-9_11

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