Abstract
The PEL1/PGS1 gene of the yeast Saccharomyces cerevisiae is essential for the viability of rho –/rho° mutants and the normal cardiolipin content of cells. The PEL1-GFP fusion gene has been found to complement the pel1/pgs1 mutation and its fluorescent protein was localized to mitochondria similarly to the β-galactosidase activity of a protein encoded by the PEL1-lacZ fusion gene. The expression of the PEL1-lacZ reporter gene was repressed in cells grown in the presence of inositol and choline, reduced in the ino2 and ino4 strains, but constitutive in the opi1 null-mutant strain. The results demonstrate that Pel1p, playing a vital role in cells impaired in the mitochondrial DNA, is localized in the mitochondria and expressed in response to inositol and choline.
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Received: 15 June / 15 July 1998
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Džugasová, V., Obernauerová, M., Horváthová, K. et al. Phosphatidylglycerolphosphate synthase encoded by the PEL1/PGS1 gene in Saccharomyces cerevisiae is localized in mitochondria and its expression is regulated by phospholipid precursors. Curr Genet 34, 297–302 (1998). https://doi.org/10.1007/s002940050399
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DOI: https://doi.org/10.1007/s002940050399