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Inflammation, Tumor Progression, and Immune Suppression

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The Tumor Immunoenvironment

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Abstract

Solid tumors consist of tumor cells and a heterogeneous mixture of host cells of both hematopoietic and non-hematopoietic origin. Although some of the host cells have anti-tumor activity, many have been co-opted by tumor-secreted factors and are immune suppressive. Two populations of cells of myeloid origin, myeloid-derived suppressor cells (MDSC) and M2-type macrophages, are potent immune suppressive cells that are particularly prevalent in solid tumors. MDSC and M2 macrophages use multiple mechanisms to individually promote immune suppression and amplify their effects through cross-talk. This chapter will summarize the characteristics of these two myeloid cell populations and then focus on the role of tumor-associated inflammation in inducing MDSC and M2 macrophage development and function.

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Abbreviations

ADAM17:

Disintegrin and metalloproteinase 17

DC:

Dendritic cells

MDSC:

Myeloid-derived suppressor cells

MO-MDSC:

Monocytic MDSC

NK:

Natural killer cells

PGE2:

Prostaglandin E2

PMN-MDSC:

Granulocytic/neutrophilic MDSC

TLR:

Toll-like receptor

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Acknowledgments

Original studies were supported by NIH RO1CA115880, RO1CA84232 (SOR), and American Cancer Society IRG-97-153-07 (PS).

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Authors and Affiliations

  1. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, 21250, USA

    Suzanne Ostrand-Rosenberg & Pratima Sinha

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  1. Suzanne Ostrand-Rosenberg
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  2. Pratima Sinha
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Correspondence to Suzanne Ostrand-Rosenberg .

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Editors and Affiliations

  1. Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street Scaife Hal, Pittsburgh, 15213, Pennsylvania, USA

    Michael R. Shurin

  2. , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Viktor Umansky

  3. , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Post Office B, Frederick, 21702, Maryland, USA

    Anatoli Malyguine

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Ostrand-Rosenberg, S., Sinha, P. (2013). Inflammation, Tumor Progression, and Immune Suppression. In: Shurin, M., Umansky, V., Malyguine, A. (eds) The Tumor Immunoenvironment. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6217-6_7

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