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Phosphoinositides in Insulin Action and Diabetes

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Phosphoinositides and Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 362))

Abstract

Phosphoinositides play an essential role in insulin signaling, serving as a localization signal for a variety of proteins that participate in the regulation of cellular growth and metabolism. This chapter will examine the regulation and localization of phosphoinositide species, and will explore the roles of these lipids in insulin action. We will also discuss the changes in phosphoinositide metabolism that occur in various pathophysiological states such as insulin resistance and diabetes.

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Acknowledgments

The authors would like to thank Drs. Dara Leto, David Buchner, Binbin Lu, Irit Hochberg and Diane Fingar (University of Michigan), and Dr. Alan Cheng (University of Louisville) for critical discussions and suggestions during the writing of this chapter.

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    Dave Bridges & Alan R. Saltiel

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    MARCO FALASCA

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Bridges, D., Saltiel, A.R. (2012). Phosphoinositides in Insulin Action and Diabetes. In: FALASCA, M. (eds) Phosphoinositides and Disease. Current Topics in Microbiology and Immunology, vol 362. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5025-8_3

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