Phosphoinositides and Disease

  • MARCO FALASCA

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 362)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Tania Maffucci
    Pages 1-42
  3. Alessandra Ghigo, Alessia Perino, Emilio Hirsch
    Pages 43-60
  4. Dave Bridges, Alan R. Saltiel
    Pages 61-85
  5. Peter J. Wen, Shona L. Osborne, Frederic A. Meunier
    Pages 87-98
  6. François Vergez, Christian Recher, Bernard Payrastre
    Pages 163-184
  7. Leonela Amoasii, Karim Hnia, Jocelyn Laporte
    Pages 209-233
  8. Sara Mongiorgi, Matilde Y. Follo, Cristina Clissa, Roberto Giardino, Milena Fini, Lucia Manzoli et al.
    Pages 235-245
  9. Sandra Hakim, Micka C. Bertucci, Sarah E. Conduit, David L. Vuong, Christina A. Mitchell
    Pages 247-314
  10. Back Matter
    Pages 315-318

About this book

Introduction

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field  and where it could go from here.

Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

Keywords

Inositol Phosphates Phosphoinositides

Editors and affiliations

  • MARCO FALASCA
    • 1
  1. 1.CTR DIABETES BARTSQueen Mary University of London, UKLONDON E1 2ATUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-5025-8
  • Copyright Information Springer Science+Business Media Dordrecht 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-5024-1
  • Online ISBN 978-94-007-5025-8
  • Series Print ISSN 0070-217X
  • About this book