Abstract
Spermatogenesis is the process by which the primordial germ cells transform into highly specialized mature spermatozoa. This is a complex process which takes place in the seminiferous tubules of the male gonad (Testis). Spermatogenesis results in the generation of daughter cells which can transfer the genetic material to the next generation through the process of reproduction. The entire spermatogenic process can be broadly classified into four important steps. This process is under the control of several extrinsic and intrinsic factors. Hypothalamo Pituitary Testicular axis which involves gonadotropin releasing hormone (GnRH) neurons with its upstream regulators, gonadotropins (Follicle Stimulating Hormone and Lutenizing Hormone) and the testosterone form the major regulators of spermatogenesis. Sertoli cells (SC) are the major intrinsic factor controlling spermatogenesis. Apart from providing structural and immunological support to the germ cells, SC also secrete Inhibin B which acts in paracrine mechanism supporting spermatogenesis. A thorough knowledge of the interplay of the endocrine factors in spermatogenesis is the basis for the effective management of male infertility.
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References
Andersson AM, Skakkebaek NE. Serum inhibin B levels during male childhood and puberty. Mol Cell Endocrinol. 2001;180(1–2):103–7.
Carreau S, Wolczynski S, et al. Aromatase, oestrogens and human male reproduction. Philos Trans R Soc Lond B Biol Sci. 2010;365(1546):1571–9.
de Kretser DM, Loveland KL, et al. Spermatogenesis. Hum Reprod. 1998;13 Suppl 1:1–8.
Ehmcke J, Wistuba J, Schlatt S. Spermatogonia, physiology, pathology and clinical relevance. Hum Reprod Update. 2006;12:275–82.
Griseold MD. Interaction between germ cells and sertoli cells in the testis. Biol Reprod. 1995;52:211–6.
Joachim W, Jan-Bernd S, Marc L. Mammalian spermatogenesis. Funct Dev Embryol. 2007;1:99–117.
Kerr JB, De Kretser D. Functional morphology of the testis. In: Jameson JL, De Groot LJ, editors. Endocrinology. 6th ed. Philadelphia: Saunders Elsevier; 2010. p. 2440–68.
Kierszenbaum AL. Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths. Mol Reprod Dev. 2002;63:269–72.
Lambard S, Galeraud-Denis I, et al. Human immature germ cells and ejaculated spermatozoa contain aromatase and oestrogen receptors. J Mol Endocrinol. 2004;32(1):279–89.
Mahmoud H, Eitan L. Regulation of spermatogenesis by paracrine/autocrine testicular factors. Asian J Androl. 2004;6:259–68.
Matsumoto AM, Bremner WJ. Testicular disorders. In: Melmed S, Polonsky KS, editors. Williams textbook of endocrinology. 12th ed. Philadelphia: Saunders Elsevier; 2011. p. 688–777.
Skorupskaite K, George JT. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485–500.
Walker WH, Cheng J. FSH and testosterone signaling in Sertoli cells. Reproduction. 2005;130:15–28.
Yan HH, Mruk DD, et al. Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells. FASEB J. 2008;22:1945–59.
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Bharath, R. (2017). Physiology and Endocrinology of Spermatogenesis. In: Gunasekaran, K., Pandiyan, N. (eds) Male Infertility. Springer, New Delhi. https://doi.org/10.1007/978-81-322-3604-7_2
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DOI: https://doi.org/10.1007/978-81-322-3604-7_2
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