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Localising Receptors and Channels Across the Dendritic Arbour

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Dendrites

Abstract

In central neurons, the strength and the number of excitatory and inhibitory synapses to a large extent determine the transfer of information from one neuron to another. The presence of multiple active conductances distributed throughout the highly arborised dendritic tree endows dendrites with the capacity to filter and modulate the evoked synaptic potentials and allows adequate representation of distal synaptic inputs in the soma for further integration and processing. Furthermore, active properties of the dendritic membrane enable dynamic modulation of neuronal excitability and thereby influence the firing output. In this chapter, we will review the distribution of dominant voltage- and ligand-gated ion channels and receptors in dendrites and their contribution to several aspects of dendritic computation.

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Authors and Affiliations

  1. Molecular Physiology Group, Leibniz Institute for Neurobiology, Magdeburg, D-39118, Germany

    Arthur Bikbaev & Martin Heine

  2. Neuroplasticity Group, Leibniz Institute for Neurobiology, Magdeburg, D-39118, Germany

    Maël Duménieu & Jeffrey Lopez-Rojas

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  1. Arthur Bikbaev
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  2. Maël Duménieu
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  3. Jeffrey Lopez-Rojas
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  4. Martin Heine
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Correspondence to Arthur Bikbaev or Martin Heine .

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  1. Graduate School of Science, The University of Tokyo, Tokyo, Japan

    Kazuo Emoto

  2. Department of Biological Structure, University of Washington, Seattle, Washington, USA

    Rachel Wong

  3. Department of Pathology, University of California San Francisco, San Francisco, California, USA

    Eric Huang

  4. Faculty of Science, Utrecht University, Utrecht, The Netherlands

    Casper Hoogenraad

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Bikbaev, A., Duménieu, M., Lopez-Rojas, J., Heine, M. (2016). Localising Receptors and Channels Across the Dendritic Arbour. In: Emoto, K., Wong, R., Huang, E., Hoogenraad, C. (eds) Dendrites. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56050-0_16

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