Summary
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1.
Theα subunit of the purified voltage-sensitive sodium channel from rat brain is rapidly phosphorylated to the extent of 3–4 mol phosphate/mol by purified protein kinase C.
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2.
Theα subunit of the native sodium channel in synaptosomal membranes is also phosphorylated by added protein kinase C as assessed by specific immunoprecipitation and polyacrylamide gel electrophoresis of labeled membranes.
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3.
Our results suggest coordinate regulation of sodium channel phosphorylation state by cAMP-dependent and calcium/phospholipid-dependent protein kinases.
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Costa, M.R.C., Catterall, W.A. Phosphorylation of theα subunit of the sodium channel by protein kinase C. Cell Mol Neurobiol 4, 291–297 (1984). https://doi.org/10.1007/BF00733592
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DOI: https://doi.org/10.1007/BF00733592