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Strategies to Enhance Biological Tendon-Bone Healing in Anterior Cruciate Ligament Reconstruction

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ACL Injury and Its Treatment

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Abstract

Tissue engineering techniques to enhance tendon-bone healing in anterior cruciate ligament (ACL) reconstruction, including stem cells and growth factors/cytokines, are gaining wide acceptance, and their clinical feasibility has also been recognized. Among them, vascular stem cells at the site of ruptured ACL, which have high proliferation and multi-differentiation potential, accelerate tendon-bone healing by enhancing angiogenesis and osteogenesis in human-rat xenotransplantation and canine autologous transplantation model of ACL reconstruction. A pilot clinical study, which used ruptured tissue for ACL reconstruction, indicated reduction of tunnel enlargement despite no improvement in clinical scores. However, for effective clinical application in future, detailed analysis is required regarding enrolled patient demographic parameters, such as age, sex, surgical timing, and type of ACL injury. This chapter highlights effectiveness of vascular stem cells application for early tendon-bone healing in ACL reconstruction, providing an insight for future strategies.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Tomoyuki Matsumoto M.D. & Ryosuke Kuroda

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  1. Tomoyuki Matsumoto M.D.
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  2. Ryosuke Kuroda
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Correspondence to Tomoyuki Matsumoto M.D. .

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  1. Hiroshima University, Hiroshima, Hiroshima, Japan

    Mitsuo Ochi

  2. Sports Orthopaedic Center, Yukioka Hospital, Osaka, Osaka, Japan

    Konsei Shino

  3. Graduate School of Medicine, Hokkaido University , Sapporo, Japan

    Kazunori Yasuda

  4. Graduate School of Medicine, Kobe University, Kobe, Japan

    Masahiro Kurosaka

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Matsumoto, T., Kuroda, R. (2016). Strategies to Enhance Biological Tendon-Bone Healing in Anterior Cruciate Ligament Reconstruction. In: Ochi, M., Shino, K., Yasuda, K., Kurosaka, M. (eds) ACL Injury and Its Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55858-3_42

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