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Potential Pathways in the Pathogenesis of IgG4-Related Disease

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IgG4-Related Kidney Disease

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Abstract

IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 and a marked infiltration of IgG4-positive plasma cells into affected organs. Regarding the immunological aspects of this disease, it is well known that IgG4 is induced by T helper type 2 (Th2) cytokines such as interleukin (IL)-4 and IL-13. Thus, IgG4-RD is considered to be a Th2-predominant disease. In addition, innate immune cells have recently received increasing attention with regards to the initiation of IgG4-RD. Exploring the mechanism of innate and acquired immunity in IgG4-RD is a highly promising field of investigation. In this chapter, we focus on the selective localization and functions of individual Th subsets and innate immune cells to clarify the contribution of these cells to the pathogenesis of IgG4-RD.

Competing interests: The authors declare no competing interests.

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Authors and Affiliations

  1. Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Masafumi Moriyama & Seiji Nakamura

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  1. Masafumi Moriyama
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  2. Seiji Nakamura
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Correspondence to Seiji Nakamura .

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Editors and Affiliations

  1. Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Takao Saito

  2. Rheumatology Clinic / Yawkey 2, Massachusetts General Hospital, Boston, Massachusetts, USA

    John H. Stone

  3. Department of Internal Medicine, Faculty of Medicine Fukuoka University, Fukuoka, Japan

    Hitoshi Nakashima

  4. Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan

    Takako Saeki

  5. Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan

    Mitsuhiro Kawano

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Moriyama, M., Nakamura, S. (2016). Potential Pathways in the Pathogenesis of IgG4-Related Disease. In: Saito, T., Stone, J., Nakashima, H., Saeki, T., Kawano, M. (eds) IgG4-Related Kidney Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55687-9_3

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