Abstract
Knowledge about the nature of cancer has been increasing, in part because of the development and use of mouse models of cancer that recapitulate the situation of cancer patients in the laboratory and help to elucidate the molecular mechanisms underlying carcinogenesis. Mouse models have been, and will be, used in cancer research until we find a cure for cancer. Over the last two decades in particular, mouse models of cancer have played an increasingly significant role in research aimed at translating achievements in basic science to clinical practice to establish the best therapies and assessments to overcome cancer. One of the most powerful approaches in this field is the use of genetically engineered mouse models carrying the genetic alterations identified in clinical specimens, which has become generalized and accelerates the development of novel therapies and diagnostic methods.
In this section, we first provide an overview of the mouse models of cancer and then shed new light on the genetically engineered mouse models that have been used in pancreatic cancer research to obtain clues regarding a cure and to allow the detection of this disease at an early stage.
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Ikehara, Y. (2015). Mouse Models of Cancer. In: Taniguchi, N., Endo, T., Hart, G., Seeberger, P., Wong, CH. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54841-6_194
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DOI: https://doi.org/10.1007/978-4-431-54841-6_194
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Publisher Name: Springer, Tokyo
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Online ISBN: 978-4-431-54841-6
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