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Table of contents

  1. Front Matter
    Pages i-lxii
  2. Introduction to Glycoscience

    1. Front Matter
      Pages 1-1
    2. Richard D. Cummings
      Pages 3-9
    3. Chi-Huey Wong, Naoyuki Taniguchi
      Pages 11-14
  3. Analytical and Structural Approach: Technical Description for Analyzing Glycans

    1. Front Matter
      Pages 15-15
    2. Koichi Honke, Norihiro Kotani
      Pages 17-23
    3. Yan Liu, Robert A. Childs, Ten Feizi
      Pages 25-34
    4. Chung-Yi Wu, Chi-Huey Wong
      Pages 35-43
    5. Chung-Yi Wu, Chi-Huey Wong
      Pages 45-52
    6. Stuart M. Haslam, Poh-Choo Pang, Aristotelis Antonopoulos, Anne Dell
      Pages 69-77
    7. Akihiko Kameyama, Yu-ki Matsuno
      Pages 94-101
    8. Kazuki Nakajima, Naoyuki Taniguchi
      Pages 103-110
    9. Akemi Suzuki, Kunihiro Sano, Minoru Suzuki, Yoshikatsu Umemura, Hideshi Fujiwake
      Pages 147-153
    10. Michael Tiemeyer, Kazuhiro Aoki
      Pages 155-161
    11. Yasuo Suda, Xu Zhang, Sachiko Nakamura-Tsuruta, Michael Sobel, Toshiomi Okuno, Masahiro Wakao
      Pages 163-174
    12. Hisayoshi Makyio, Ryuichi Kato
      Pages 175-182
  4. Glycoinformatics: New Approach for Informatics and Databases for Glycoscience

    1. Front Matter
      Pages 183-183
    2. Kiyoko F. Aoki-Kinoshita
      Pages 185-192
    3. Daniel Kolarich, Rene Ranzinger, Carsten Kettner, William S. York
      Pages 193-200
    4. Kiyoko F. Aoki-Kinoshita
      Pages 201-207
    5. Toshihide Shikanai, Hisashi Narimatsu
      Pages 209-213
    6. Matthew P. Campbell, Robyn Peterson, Elisabeth Gasteiger, Julien Mariethoz, Frederique Lisacek, Nicolle H. Packer
      Pages 215-222
    7. Miguel A. Rojas-Macias, Alexander Loss, Andreas Bohne-Lang, Martin Frank, Thomas Lütteke
      Pages 233-239
    8. Philip Toukach, Ksenia Egorova
      Pages 241-250
    9. Rene Ranzinger, William S. York
      Pages 259-265
    10. Shujiro Okuda, Hiromi Nakao, Toshisuke Kawasaki
      Pages 267-273
    11. Julien Mariethoz, Khaled Khatib, Matthew P. Campbell, Nicolle H. Packer, Elaine Mullen, Frederique Lisacek
      Pages 275-282
    12. Serge Pérez, Alain Rivet, Anne Imberty
      Pages 283-289
  5. Chemoenzymatic Synthesis of Glycans: Chemical and Enzymatic Methods of Glycan Synthesis

    1. Front Matter
      Pages 291-291
    2. Chi-Huey Wong
      Pages 293-294
    3. Amit Kumar, Richard R. Schmidt
      Pages 295-303
    4. Yukishige Ito, Akira Seko, Yoichi Takeda
      Pages 305-312
    5. Masayuki Izumi, Ryo Okamoto, Yasuhiro Kajihara
      Pages 313-321
    6. Ci Xu, Xuechen Li
      Pages 323-330
    7. Makoto Kiso, Hideharu Ishida, Hiromune Ando, Akihiro Imamura
      Pages 331-338
    8. David Crich
      Pages 339-343
    9. Chung-Yi Wu, Chi-Huey Wong
      Pages 345-351
    10. Shino Manabe
      Pages 359-363
    11. Medel Manuel L. Zulueta, Shang-Cheng Hung
      Pages 365-371

About this book

Introduction

The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.

Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

Keywords

Chemical glycobiology Glyco-biomarkers Glycoimmunology Glyconeurology Systems glycobiology

Editors and affiliations

  • Naoyuki Taniguchi
    • 1
  • Tamao Endo
    • 2
  • Gerald W. Hart
    • 3
  • Peter H. Seeberger
    • 4
  • Chi-Huey Wong
    • 5
  1. 1.Systems Glycobiology Research GroupRIKEN-Max Planck Joint Research Center for Systems Chemical BiologyWakoJapan
  2. 2.Tokyo Metropolitan Institute of GerontologyTokyo Metropolitan Geriatric Hospital and Institute of GerontologyTokyoJapan
  3. 3.Department of Biological ChemistryJohns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Department of Biomolecular SystemsMax-Planck-Institute of Colloids and InterfacesPotsdamGermany
  5. 5.Academica SinicaNanKangTaiwan

Bibliographic information