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UDP-GlcNAc: BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2)

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Handbook of Glycosyltransferases and Related Genes

Abstract

β1,3-N-acetylglucosaminyltransferase 2 (β3GnT2) synthesizes a unique carbohydrate structure known as polylactosamine (poly-N-acetyllactosamine). Polylactosamines are carried on N- and O-glycans and glycolipids. Polylactosamine-containing repeats of the N-acetyllactosamine (LacNAc) unit (Gal[galactose]β1-4GlcNAc[N-acetylglucosamine] β1-3)n represent a fundamental structure of glycans carried on N- and O-glycans, as well as on glycosphingolipids (glycolipids). Polylactosamines are synthesized coordinately by the alternative action of a β1,4-galactosyltransferase (β4GalT) and a β1,3-N-acetylglucosaminyltransferase (β3GnT).

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Authors and Affiliations

  1. Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Central-2, 1-1-1 Umezono, 305-8568, Tsukuba, Ibaraki, Japan

    Dr. Akira Togayachi & Prof. Hisashi Narimatsu

Authors
  1. Dr. Akira Togayachi
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  2. Prof. Hisashi Narimatsu
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Corresponding author

Correspondence to Akira Togayachi .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Togayachi, A., Narimatsu, H. (2014). UDP-GlcNAc: BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_89

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