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Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 3 (GCNT3)

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Handbook of Glycosyltransferases and Related Genes

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Abstract

GCNT3 (C2GnT2/M) is a unique glycosyltransferase in having multiple enzymatic activities (Yeh et al. 1999; Schwientek et al. 1999). It was shown to have core2 and core4 branching as well as I branching, mainly dIGnT, enzymatic activities. GCNT3 is the only glycosyltransferase identified up-to-date to possess core4GnT activity. This is in line with the observations that the presence of core4GnT activity is always associated with core2GnT activity (Brockhausen et al. 1986; Ropp et al. 1991; Yang et al. 1994; Vavasseur et al. 1995). GCNT3 is highly expressed in mucin-producing tissues (Yeh et al. 1999; Schwientek et al. 1999), indicating a pivotal role in mucosal functions.

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Authors and Affiliations

  1. Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037-1005, USA

    Prof. Minoru Fukuda

  2. Tumor Microenvironment Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

    Dr. Jiunn-Chern (Gene) Yeh

Authors
  1. Dr. Jiunn-Chern (Gene) Yeh
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  2. Prof. Minoru Fukuda
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Corresponding author

Correspondence to Minoru Fukuda .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Yeh, JC., Fukuda, M. (2014). Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 3 (GCNT3). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_26

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