Abstract
Peroxisomes started their life relatively late in comparison to many of their earlier discovered siblings among the set of cell organelles such as the nuclei, the mitochondria, the chloroplasts, or the ER. In addition, the metabolic pathways first described to this organelle did not immediately suggest the biological significance of peroxisomes for cells, distinct tissues, or even a total organism as we know it today. The major unexpected breakthrough bringing them to the limelight of cell biology came with the discovery of the peroxisomal diseases. For 25 years now, they triggered research on peroxisome biogenesis, a scientific journey full of excitement and unexpected results, as the authors experienced themselves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Agne B (2002) Untersuchungen zur Funktion von RING-Finger-Proteinen beim peroxisomalen Protein Import der Hefe Saccharomyces cerevisiae. Dissertation, Ruhr-Universität Bochum, Bochum
Baker A, Kaplan CP, Pool MR (1992) Protein targeting and translocation; a comparative survey. Biol Rev Camb Philos Soc 71:637–702
Berger J, Gärtner J (2006) X-linked adrenoleukodystrophy: clinical, biochemical and pathogenetic aspects. Biochim Biophys Acta 1763:1721–1732
Breidenbach RW, Beevers H (1967) Association of the glyoxylate cycle enzymes in a novel subcellular particle from castor bean endosperm. Biochem Biophys Res Commun 27:462–469
Collins CS, Kalish JE, Morrell JC, McCaffery JM, Gould SJ (2000) The peroxisome biogenesis factors Pex4p, Pex22p, Pex1p, and Pex6p act in the terminal steps of peroxisomal matrix protein import. Mol Cell Biol 20:7516–7526
Cooper TG, Beevers H (1969) Mitochondria and glyoxysomes from castor bean endosperm. Enzyme constitutents and catalytic capacity. J Biol Chem 244:3507–3513
Cregg JM, van der Klei IJ, Sulter GJ, Veenhuis M, Harder W (1990) Peroxisome-deficient mutants of Hansenula polymorpha. Yeast 6:87–97
Dammai V, Subramani S (2001) The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell 105:187–196
de Hoop MJ, Ab G (1992) Import of proteins into peroxisomes and other microbodies. Biochem J 286:657–669
DeDuve C, Baudhuin P (1966) Peroxisomes (microbodies and related particles). Physiol Rev 46:323–357
Distel B, Erdmann R, Gould SJ, Blobel G, Crane DI, Cregg JM, Dodt G, Fujiki Y, Goodman JM, Just WW, Kiel JAKW, Kunau W-H, Lazarow PB, Mannaerts GP, Moser HW, Osumi T, Rachubinski RA, Roscher A, Subramani S, Tabak HF, Tsukamoto T, Valle D, van der Klei I, van Veldhoven PP, Veenhuis M (1996) A unified nomenclature for peroxisome biogenesis factors. J Cell Biol 135:1–3
Dodt G, Gould SJ (1996) Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. J Cell Biol 135:1763–1774
Erdmann R, Veenhuis M, Mertens D, Kunau W-H (1989) Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 86:5419–5423
Fujiki Y, Matsuzono Y, Matsuzaki T, Fransen M (2006) Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions. Biochim Biophys Acta 1763:1639–1646
Fujiki Y, Nashiro C, Miyata N, Tamura S, Okumoto K (2012) New insights into dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p in shuttling of PTS1-receptor Pex5p during peroxisome biogenesis. Biochim Biophys Acta 1823:145–149
Goldfischer S, Moor CL, Johnson AB, Spiro AJ, Valsamis MP, Wisniewski HK, Ritch RH, Norton WT, Rapin I, Gerner LM (1973) Peroxisomal and mitochondrial defects in cerebrohepatorenal syndrome. Science 182:62–64
Gould SJ, Keller GA, Subramani S (1987) Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J Cell Biol 105:2923–2931
Gould SJ, McCollum D, Spong AP, Heyman JA, Subramani S (1992) Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly. Yeast 8:613–628
Gouveia AM, Reguenga C, Oliveira ME, Sa-Miranda C, Azevedo JE (2000) Characterization of peroxisomal Pex5p from rat liver: Pex5p in the Pex5p-Pex14p membrane complex is a transmembrane protein. J Biol Chem 275:32444–32451
Hayashi M, Nishimura M (2006) Arabidopsis thaliana–a model organism to study plant peroxisomes. Biochim Biophys Acta 1763:1382–1391
Hazra PP, Suriapranata I, Snyder WB, Subramani S (2002) Peroxisome remnants in pex3Delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3:560–574
Hettema EH, Girzalsky W, van Den Berg M, Erdmann R, Distel B (2000) Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins. EMBO J 19:223–233
Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF (2005) Contribution of the endoplasmic reticulum to peroxisome formation. Cell 122:89–95
Kunau W-H (1998) Peroxisome biogenesis: from yeast to man. Curr Opin Microbiol 1:232–237
Kunau W-H, Erdmann R (1998) Peroxisome biogenesis: back to the endoplasmic reticulum? Curr Biol 8:299–302
Kunau W (2001) Peroxisomes: the extended shuttle to the peroxisome matrix. Curr Biol 11:R659–R662
Lazarow PB (2006) The import receptor Pex7p and the PTS2 targeting sequence. Biochim Biophys Acta 1763:1599–1604
Lazarow PB, De Duve C (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. Proc Natl Acad Sci USA 73(6):2043–2046
Lazarow PB, Fujiki Y (1985) Biogenesis of peroxisomes. Annu Rev Cell Biol 1:489–530
Liu H, Tan X, Veenhuis M, McCollum D, Cregg JM (1992) An efficient screen for peroxisome-deficient mutants of Pichia pastoris. J Bacteriol 174:4943–4951
Ma C, Schumann U, Rayapuram N, Subramani S (2009) The peroxisomal matrix import of Pex8p requires only PTS receptors and Pex14p. Mol Biol Cell 20:3680–3689
Marzioch M, Erdmann R, Veenhuis M, Kunau W-H (1994) PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. EMBO J 13:4908–4918
McNew JA, Goodman JM (1996) The targeting and assembly of peroxisomal proteins: some old rules do not apply. Trends Biochem Sci 21:54–58
Meinecke M, Cizmowski C, Schliebs W, Kruger V, Beck S, Wagner R, Erdmann R (2010) The peroxisomal importomer constitutes a large and highly dynamic pore. Nat Cell Biol 12:273–277
Moser HW (1993) Peroxisomal diseases. Adv Hum Genet 21:443–451
Nuttall JM, Motley A, Hettema EH (2011) Peroxisome biogenesis: recent advances. Curr Opin Cell Biol 23:421–426
Nuttley WM, Szilard RK, Smith JJ, Veenhuis M, Rachubinski RA (1995) The PAH2 gene is required for peroxisome assembly in the methylotrophic yeast Hansenula polymorpha and encodes a member of the tetratricopeptide repeat family of proteins. Gene 160:33–39
Opperdoes FR (1988) Glycosomes may provide clues to the import of peroxisomal proteins. Trends Biochem Sci 13:255–260
Platta HW, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R (2005) Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol 7:817–822
Purdue PE, Lazarow PB (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17:701–752
Rhodin J (1954) Correlation of ultrastructural organization and function in normal and experimentally changed peroxisomal convoluted tubule cells of the mouse kidney. Dissertation, Aktiebolaget Godvil, Stockholm
Rucktäschel R, Girzalsky W, Erdmann R (2011) Protein import machineries of peroxisomes. Biochim Biophys Acta 1808:892–900
Samsom JF, Jakobs C, van de Klei-van Moorsel J, Smit LM, Schutgens RB, Wanders RJ (1992) Zellweger syndrome in a preterm, small for gestational age infant. J Inherit Metab Dis 15:75–83
Schäfer A, Kerssen D, Veenhuis M, Kunau WH, Schliebs W (2004) Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p. Mol Cell Biol 24:8895–8906
Schliebs W, Girzalsky W, Erdmann R (2010) Peroxisomal protein import and ERAD: variations on a common theme. Nat Rev Mol Cell Biol 11:885–890
Schliebs W, Kunau WH (2006) PTS2 co-receptors: diverse proteins with common features. Biochim Biophys Acta 1763:1605–1612
Schutgens RB, Heymans HS, Wanders RJ, van den Bosch H, Tager JM (1986) Peroxisomal disorders: a newly recognised group of genetic diseases. Eur J Pediatr 144:430–440
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW (2006) Peroxisome biogenesis disorders. Biochim Biophys Acta 1763:1733–1748
Swinkels BW, Gould SJ, Bodnar AG, Rachubinski RA, Subramani S (1991) A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J 10:3255–3262
Szilard RK, Titorenko VI, Veenhuis M, Rachubinski RA (1995) Pay32p of the Yeast Yarrowia lipolytica is an intraperoxisomal component of the matrix protein translocation machinery. J Cell Biol 131:1453–1469
Tabak HF, Braakman I, van der Zand A (2013) Peroxisome formation and maintenance are dependent on the endoplasmic reticulum. Annu Rev Biochem 82:723–744
Tager JM, Aerts JM, van den Bogert C, Wanders RJ (1994) Signals on proteins, intracellular targeting and inborn errors of organellar metabolism. J Inherit Metab Dis 17:459–468
Theodoulou FL, Bernhardt K, Linka N, Baker A (2013) Peroxisome membrane proteins: multiple trafficking routes and multiple functions? Biochem J 451:345–352
Tolbert NE (1981) Metabolic pathways in peroxisomes and glyoxysomes. Annu Rev Biochem 50:133–157
Tsukamoto T, Yokota S, Fujiki Y (1990) Isolation and characterization of Chinese hamster ovary cell mutants defective in assembly of peroxisomes. J Cell Biol 110:651–660
van der Klei IJ, Veenhuis M (2006) Yeast and filamentous fungi as model organisms in microbody research. Biochim Biophys Acta 1763:1364–1373
van der Leij I, van den Berg M, Boot R, Franse MM, Distel B, Tabak HF (1992) Isolation of peroxisome assembly mutants from Saccharomyces cerevisiae with different morphologies using a novel positive selection procedure. J Cell Biol 119:153–162
Wanders RJ, Waterham HR (2006) Peroxisomal disorders: the single peroxisomal enzyme deficiencies. Biochim Biophys Acta 1763:1707–1720
Waterham HR, Ebberink MS (2012) Genetics and molecular basis of human peroxisome biogenesis disorders. Biochim Biophys Acta 1822:1430–1441
Zellweger H (1965) Genetic Aspects of Neurological Disease. Arch Intern Med 115:387–397
Zhang JW, Han Y, Lazarow PB (1991) Novel peroxisome clustering mutants and peroxisome biogenesis mutants of Saccharomyces cerevisiae. J Cell Biol 123:1133–1147
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Wien
About this chapter
Cite this chapter
Just, W., Kunau, WH. (2014). History and Discovery of Peroxins. In: Brocard, C., Hartig, A. (eds) Molecular Machines Involved in Peroxisome Biogenesis and Maintenance. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1788-0_1
Download citation
DOI: https://doi.org/10.1007/978-3-7091-1788-0_1
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-1787-3
Online ISBN: 978-3-7091-1788-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)