Abstract
There are many causes of skin necrosis. The process resulting in skin necrosis begins with the sudden thrombotic occlusion of single or multiple blood vessels supplying the tissue. Compromised blood vessels leak red cells into the surrounding tissues where they become trapped within the ensuing tissue that is turning necrotic. The subsequent deoxygenation of haemoglobin in the red blood cells causes tissue hypoxia and renders it black in colour. While tissue is dying, cells release cytokines promoting inflammation. At the boundary of necrotic tissue, blood vessels dilate resulting in hyperaemia giving rise to the dusky grey-red colour of the surrounding skin. Thus, the successful diagnosis of skin necrosis depends upon the identification of the condition that causes vessel thrombosis.
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References
Malone PC. Further reflections on Virchow’s triad. South Med J. 2005;98(1):125.
Trans Atlantic Inter-Society Consensus Document on Management of Peripheral Arterial Disease (TASC) II. Eur J Vasc Endovasc Surg. 2007;33(suppl 1):2–42.
Graaf JC, Ubbink DT, Legemate DL, Haan RJ, Jacobs MJ. The usefulness of a laser Doppler in the measurement of toe blood pressures. J Vasc Surg. 2000;32:1172–9.
McKinnell T, Pape S. Measurements in burns. In: Mani R, Romanelli M, Shukla VK, editors. Measurements in wound healing – science and practice. London: Springer; 2012.
Marston M, Mani R. Imaging the microcirculation – options for the wound physicians. J Wound Technol. 2012;16:26–32.
Romanelli M, Dini V, Mani R. Skin and vascular assessments. In: Mani R, Romanelli M, Shukla VK, editors. In Measurements in wound healing – Science and Practice. London: Springer; 2012. p. 199–223. ISBN 978-1-4471-2987-5.
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Luk, T.L., Mani, R. (2015). Skin Necrosis and the Need for Vascular Assessments. In: Téot, L., Meaume, S., Akita, S., Ennis, W.J., del Marmol, V. (eds) Skin Necrosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1241-0_5
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DOI: https://doi.org/10.1007/978-3-7091-1241-0_5
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