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Andrologie für die gynäkologische Praxis

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Gynäkologische Endokrinologie und Kinderwunschtherapie

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Zusammenfassung

Unerfüllter Kinderwunsch ist das Resultat von weiblichen und männlichen Infertilitätsfaktoren. Bei mindestens der Hälfte der betroffenen Paare ist mit Fertilitätsstörungen aufseiten des Mannes zu rechnen, die auf verschiedenste Ursachen zurückzuführen sein können. Nach ihrer Lokalisation lassen sich Störungen der Hoden, der ableitenden Samenwege und akzessorischen Drüsen, der Samendeposition, des übergeordneten Hypothalamus-Hypophysen-Systems sowie seltene Androgenrezeptor- und Enzymdefekte unterscheiden. Männliche Infertilität kann hierbei der Endzustand sowohl angeborener als auch erworbener Erkrankungen sein; häufig liegen mehrere ätiopathogenetisch relevante Faktoren vor. Somit ist die Untersuchung des Mannes bei unerfülltem Kinderwunsch unverzichtbar, insbesondere auch vor Maßnahmen der assistierten Reproduktion. Bei nicht ausreichender gynäkologisch-andrologischer Kooperation besteht die Gefahr, dass aufseiten des Mannes gesundheitsrelevante Störungen unerkannt bleiben und kausale Therapieoptionen nicht genutzt werden.

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Literatur

  • Adams, C. E., & Wald, M. (2009). Risks and complications of vasectomy. The Urologic Clinics of North America, 36, 331–336.

    Article  PubMed  Google Scholar 

  • Agarwal, A., Mulgund, A., Hamada, A., & Chyatte, M. R. (2015). A unique view on male infertility around the globe. Reproductive Biology and Endocrinology, 13, 37.

    Article  PubMed  PubMed Central  Google Scholar 

  • Aitken, R. J., & Bakos, H. W. (2021). Should we be measuring DNA damage in human spermatozoa? New light on an old question. Human Reproduction, 36(5), 1175–1185. https://doi.org/10.1093/humrep/deab004

    Article  CAS  PubMed  Google Scholar 

  • AWMF. (2017). Leitlinie: Fertilitätserhaltung bei onkologischen Therapien. Level S2k, AWMF-Register Nr. 015/082, November 2017. http://www.awmf.org/leitlinien/detail/ll/015-082.html. Zugegriffen am 28.05.2023.

  • Barbonetti, A., Martorella, A., Minaldi, E., D’Andrea, S., Bardhi, D., Castellini, C., Francavilla, F., & Francavilla, S. (2019). Testicular cancer in infertile men with and without testicular microlithiasis: A systematic review and meta-analysis of case-control studies. Frontiers in Endocrinology (Lausanne), 10, 164. https://doi.org/10.3389/fendo.2019.00164

    Article  Google Scholar 

  • Barbonetti, A., Castellini, C., D’Andrea, S., Minaldi, E., Totaro, M., Francavilla, S., & Francavilla, F. (2020). Relationship between natural and intrauterine insemination-assisted live births and the degree of sperm autoimmunisation. Human Reproduction, 35, 1288–1295.

    Article  CAS  PubMed  Google Scholar 

  • Barratt, C. L. R., Björndahl, L., Menkveld, R., & Mortimer, D. (2011). ESHRE special interest group for andrology basic semen analysis course: A continued focus on accuracy, quality, efficiency and clinical relevance. Human Reproduction, 26, 3207–3212.

    Article  CAS  PubMed  Google Scholar 

  • Barratt, C. L. R., Björndahl, L., De Jonge, C. J., et al. (2017). The diagnosis of male infertility: An analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Human Reproduction Update, 23(6), 660–680.

    Article  PubMed  PubMed Central  Google Scholar 

  • Baskaran, S., Finelli, R., Agarwal, A., & Henkel, R. (2021). Diagnostic value of routine semen analysis in clinical andrology. Andrologia, 53(2), e13614. https://doi.org/10.1111/and.13614

    Article  PubMed  Google Scholar 

  • Behre, H. M., Nieschlag, E., Partsch, J., Wieacker, P., & Simoni, M. (2009). Störungen im Bereich des Hypothalamus und der Hypophyse. In E. Nieschlag, H. M. Behre, & S. Nieschlag (Hrsg.), Andrologie – Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (3. Aufl., S. 90–96). Springer.

    Google Scholar 

  • Bergmann, M. (2006). Evaluation of testicular biopsy samples from clinical perspective. In W. D. Schill, F. H. Comhaire, & T. Hargreave (Hrsg.), Andrology for the clinician (S. 454–461). Springer.

    Chapter  Google Scholar 

  • Bernie, A. M., Mata, D. A., Ramasamy, R., & Schlegel, P. N. (2015). Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia: A systematic review and meta-analysis. Fertility and Sterility, 104, 1099–1103.e1–3.

    Article  PubMed  Google Scholar 

  • Bezold, G., Politch, J. A., Kiviat, N. B., et al. (2007). Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertility and Sterility, 87, 1087–1097.

    Article  PubMed  PubMed Central  Google Scholar 

  • Björndahl, L., Mortimer, D., Barratt, C. L. R., Castilla, J. A., Menkveld, R., Kvist, U., Alvarez, J. G., & Haugen, T. B. (2010). A practical guide to basic laboratory andrology. Cambridge University Press.

    Book  Google Scholar 

  • Boehm, U., Bouloux, P. M., Dattani, M. T., de Roux, N., Dodé, C., Dunkel, L., Dwyer, A. A., Giacobini, P., Hardelin, J. P., Juul, A., Maghnie, M., Pitteloud, N., Prevot, V., Raivio, T., Tena-Sempere, M., Quinton, R., & Young, J. (2015). European Consensus Statement on congenital hypogonadotropic hypogonadism – Pathogenesis, diagnosis and treatment. Nature Reviews Endocrinology, 11(9), 547–564.

    Article  PubMed  Google Scholar 

  • Bonkat, G., Pickard, R., Bartoletti, R., Cai, T., Bruyere, F., Geerlings, S. E., Köves, B., & Wagenlehner, F. (2021). EAU Guidelines on urological infections. EAU Guidelines Office. https://uroweb.org/individual-guidelines/non-oncology-guidelines/. Zugegriffen am 28.05.2023.

  • Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavò, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M., Persani, L., & Italian Network on Central Hypogonadism. (2018). Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH). European Journal of Endocrinology, 178(1), 23–32.

    Article  CAS  PubMed  Google Scholar 

  • Braga, P. C., Pereira, S. C., Ribeiro, J. C., Sousa, M., Monteiro, M. P., Oliveira, P. F., & Alves, M. G. (2020). Late-onset hypogonadism and lifestyle-related metabolic disorders. Andrology, 8(6), 1530–1538. https://doi.org/10.1111/andr.12765

    Article  PubMed  Google Scholar 

  • Büchter, D., Behre, H. M., Kliesch, S., & Nieschlag, E. (1998). Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: A review of 42 cases. European Journal of Endocrinology, 139, 298–303.

    Article  PubMed  Google Scholar 

  • Bundesärztekammer. (2018). Richtlinie zur Entnahme und Übertragung von menschlichen Keimzellen im Rahmen der assistierten Reproduktion. Deutsches Ärzteblatt. https://doi.org/10.3238/arztebl.2018.Rili_assReproduktion_2018

  • Bundesärztekammer. (2019). Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen – Rili-BÄK. Deutsches Ärzteblatt, 111, A1583–A1618. https://doi.org/10.3238/arztebl.2019.rili_baek_QS_Labor20192312

    Article  Google Scholar 

  • Campbell, M. J., Lotti, F., Baldi, E., et al. (2021). Distribution of semen examination results 2020 – A follow up of data collated for the WHO semen analysis manual 2010. Andrology, 9(3), 817–822.

    Article  PubMed  Google Scholar 

  • van Casteren, N. J., Looijenga, L. H., & Dohle, G. R. (2009). Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. International Journal of Andrology, 32, 279–287.

    Article  PubMed  Google Scholar 

  • Chansel-Debordeaux, L., Dandieu, S., Bechoua, S., & Jimenez, C. (2015). Reproductive outcome in globozoospermic men: Update and prospects. Andrology, 3(6), 1022–1034.

    Article  CAS  PubMed  Google Scholar 

  • Chemes, H. E., & Rawe, V. Y. (2003). Sperm pathology: A step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile emn. Human Reproduction Update, 9, 405–428.

    Article  PubMed  Google Scholar 

  • Chiu, Y. H., Edifor, R., Rosner, B. A., Nassan, F. L., Gaskins, A. J., Mínguez-Alarcón, L., Williams, P. L., Tanrikut, C., Hauser, R., Chavarro, J. E., & EARTH Study Team. (2017). What does a single semen sample tell you? Implications for male factor infertility research. American Journal of Epidemiology, 186(8), 918–926. https://doi.org/10.1093/aje/kwx169

    Article  PubMed  PubMed Central  Google Scholar 

  • Colpi, G. M., Francavilla, S., Haidl, G., et al. (2018). European Academy of Andrology guideline Management of oligo-astheno-teratozoospermia. Andrology, 6(4), 513–524.

    Article  CAS  PubMed  Google Scholar 

  • Corona, G., Pizzocaro, A., Lanfranco, F., Garolla, A., Pelliccione, F., Vignozzi, L., Ferlin, A., Foresta, C., Jannini, E. A., Maggi, M., Lenzi, A., Pasquali, D., Francavilla, S., & Klinefelter ItaliaN Group (KING). (2017). Sperm recovery and ICSI outcomes in Klinefelter syndrome: A systematic review and meta-analysis. Human Reproduction Update, 23, 265–275.

    Article  CAS  PubMed  Google Scholar 

  • Corona, G., Minhas, S., Giwercman, A., Bettocchi, C., Dinkelman-Smit, M., Dohle, G., Fusco, F., Kadioglou, A., Kliesch, S., Kopa, Z., Krausz, C., Pelliccione, F., Pizzocaro, A., Rassweiler, J., Verze, P., Vignozzi, L., Weidner, W., Maggi, M., & Sofikitis, N. (2019). Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: A systematic review and meta-analysis. Human Reproduction Update, 25(6), 733–757.

    Article  PubMed  Google Scholar 

  • Corona, G., Goulis, D. G., Huhtaniemi, I., Zitzmann, M., Toppari, J., Forti, G., Vanderschueren, D., & Wu, F. C. (2020). European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. Andrology, 8(5), 970–987. https://doi.org/10.1111/andr.12770

    Article  PubMed  Google Scholar 

  • Corona, G., Vena, W., Pizzocaro, A., Pallotti, F., Paoli, D., Rastrelli, G., Baldi, E., Cilloni, N., Gacci, M., Semeraro, F., Salonia, A., Minhas, S., Pivonello, R., Sforza, A., Vignozzi, L., Isidori, A. M., Lenzi, A., Maggi, M., & Lombardo, F. (2022). Andrological effects of SARS-Cov-2 infection: A systematic review and meta-analysis. Journal of Endocrinological Investigation, 9, 1–13. https://doi.org/10.1007/s40618-022-01801-x

    Article  CAS  Google Scholar 

  • Coutton, C., Escoffier, J., Martinez, G., et al. (2015). Teratozoospermia: Spotlight on the main genetic actors in the human. Human Reproduction Update, 21(4), 455–485.

    Article  CAS  PubMed  Google Scholar 

  • Dabaja, A. A., & Schlegel, P. N. (2013). Microdissection testicular sperm extraction: An update. Asian Journal of Andrology, 15, 35–39.

    Article  PubMed  Google Scholar 

  • Damsgaard, J., Joensen, U. N., Carlsen, E., Erenpreiss, J., Blomberg Jensen, M., Matulevicius, V., Zilaitiene, B., Olesen, I. A., Perheentupa, A., Punab, M., Salzbrunn, A., Toppari, J., Virtanen, H. E., Juul, A., Skakkebæk, N. E., & Jørgensen, N. (2016). Varicocele is associated with impaired semen quality and reproductive hormone levels: A study of 7035 healthy young men from six European countries. European Urology, 70(6), 1019–1029.

    Article  CAS  PubMed  Google Scholar 

  • Datta, J., Palmer, M. J., Tanton, C., Gibson, L. J., Jones, K. G., Macdowall, W., Glasier, A., Sonnenberg, P., Field, N., Mercer, C. H., Johnson, A. M., & Wellings, K. (2016). Prevalence of infertility and help seeking among 15 000 women and men. Human Reproduction, 31(9), 2108–2118.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deruyver, Y., Vanderschueren, D., & van der Aa, F. (2014). Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: A systematic review. Andrology, 2, 20–24.

    Article  CAS  PubMed  Google Scholar 

  • Deutsches IVF-Register. (2021). DIR-Jahrbuch 2020. Journal of Reproduktionsmed Endokrinologie, 18(5), 204–246.

    Google Scholar 

  • Dohle, G. R., Arver, S., Bettocchi, C., Jones, T. H., & Kliesch, S. (2019). EAU Guidelines on male hypogonadism. EAU Guidelines Office.

    Google Scholar 

  • von Eckardstein, S., Simoni, M., Bergmann, M., Weinbauer, G. F., Gassner, P., Schepers, A. G., & Nieschlag, E. (1999). Serum inhibin B in combination with serum follicle-stimulating hormone (FSH) is a more sensitive marker than serum FSH alone for impaired spermatogenesis in men, but cannot predict the presence of sperm in testicular tissue samples. The Journal of Clinical Endocrinology and Metabolism, 84, 2496–2501.

    Google Scholar 

  • Eisenberg, M. L., Li, S., Cullen, M. R., & Baker, L. C. (2016). Increased risk of incident chronic medical conditions in infertile men: Analysis of United States claims data. Fertility and Sterility, 105, 629–636.

    Article  PubMed  Google Scholar 

  • El-Sherbiny, A. F., Ali, T. A., Hassan, E. A., Mehaney, A. B., & Elshemy, H. A. (2021). The prognostic value of seminal anti-sperm antibodies screening in men prepared for ICSI: A call to change the current antibody-directed viewpoint of sperm autoimmunity testing. Therapeutic Advances in Urology, 13. https://doi.org/10.1177/1756287220981488

  • Epelboin, S., Dulioust, E., Epelboin, L., Benachi, A., Merlet, F., & Patrat, C. (2017). Zika virus and reproduction: Facts, questions and current management. Human Reproduction Update, 23, 629–645.

    Article  PubMed  Google Scholar 

  • Fietz, D., & Bergmann, M. (2017). Functional anatomy and histology of the testis. In M. Simoni & I. Huhtaniemi (Hrsg.), Endocrinology of the testis and male reproduction. https://doi.org/10.1007/978-3-319-29456-8_9-1

  • Fietz, D., & Kliesch, S. (2022). Biopsie und Histologie des Hodens. In E. Nieschlag et al. (Hrsg.), Andrologie. Springer Reference Medizin. https://doi.org/10.1007/978-3-662-61904-9_11-1

    Chapter  Google Scholar 

  • Fijak, M., Pilatz, A., Hedger, M. P., Nicolas, N., Bhushan, S., Michel, V., Tung, K. S. K., Schuppe, H. C., & Meinhardt, A. (2018). Infectious, inflammatory and ‚autoimmune‘ male factor infertility: How do rodent models inform clinical practice? Human Reproduction Update, 24(4), 416–441.

    Article  CAS  PubMed  Google Scholar 

  • Francavilla, F., & Barbonetti, A. (2017). Male autoimmune infertility. In W. Krause & R. K. Naz (Hrsg.), Immune infertility. Impact of immune reactions on human fertility (S. 187–196). Springer.

    Google Scholar 

  • Fretz, P. C., & Sandlow, J. I. (2002). Varicocele: Current concepts in pathophysiology, diagnosis, and treatment. The Urologic Clinics of North America, 29, 921–937.

    Article  PubMed  Google Scholar 

  • Gemeinsamer Bundesausschuss der Ärzte und Krankenkassen. Richtlinien des Bundesausschusses der Ärzte und Krankenkassen über ärztliche Maßnahmen zur künstlichen Befruchtung („Richtlinien über künstliche Befruchtung“). Bundesanzeiger AT 17.10.2014 B3; letzte Änderung BAnz AT 01.06.2017 B4.

    Google Scholar 

  • Gemeinsamer Bundesausschuss der Ärzte und Krankenkassen. Richtlinie zur Kryokonservierung von Ei- oder Samenzellen oder Keimzellgewebe sowie entsprechende medizinische Maßnahmen wegen keimzellschädigender Therapie (Kryo-RL). Bundesanzeiger BAnz AT 19.02.2021 B7.

    Google Scholar 

  • Gillam, M. P., Molitch, M. E., Lombardi, G., & Colao, A. (2006). Advances in the treatment of prolactinomas. Endocrine Reviews, 27, 485–534.

    Article  CAS  PubMed  Google Scholar 

  • Goossens, E., Van Saen, D., & Tournaye, H. (2013). Spermatogonial stem cell preservation and transplantation: From research to clinic. Human Reproduction, 28(4), 897–907.

    Article  CAS  PubMed  Google Scholar 

  • Goossens, E., Jahnukainen, K., Mitchell, R. T., van Pelt, A., Pennings, G., Rives, N., Poels, J., Wyns, C., Lane, S., Rodriguez-Wallberg, K. A., Rives, A., Valli-Pulaski, H., Steimer, S., Kliesch, S., Braye, A., Andres, M. M., Medrano, J., Ramos, L., Kristensen, S. G., Andersen, C. Y., Bjarnason, R., Orwig, K. E., Neuhaus, N., & Stukenborg, J. B. (2020). Fertility preservation in boys: Recent developments and new insights. Human Reproduction Open, 2020(3), hoaa016. https://doi.org/10.1093/hropen/hoaa016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gravholt, C. H., Chang, S., Wallentin, M., Fedder, J., Moore, P., & Skakkebæk, A. (2018). Klinefelter syndrome: Integrating genetics, neuropsychology, and endocrinology. Endocrine Reviews, 39(4), 389–423. https://doi.org/10.1210/er.2017-00212

    Article  PubMed  Google Scholar 

  • Grunewald, S., Reinhardt, M., Blumenauer, V., Said, T. M., Agarwal, A., Abu Hmeidan, F., Glander, H. J., & Paasch, U. (2009). Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. Fertility and Sterility, 92, 572–577.

    Article  PubMed  Google Scholar 

  • Guzick, D. S., Overstreet, J. W., Factor-Litwack, P., Brazil, C. K., Nakajima, S. T., Coutifaris, C., Carson, S. A., Cisneros, P., Steinkampf, M. P., Hill, J. A., Xu, D., & Vogel, D. L. (2001). Sperm morphology, motility, and concentration in fertile and infertile men. The New England Journal of Medicine, 345, 1388–1393.

    Article  CAS  PubMed  Google Scholar 

  • Hadziselimovic, F. (2017). On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility. Basic and Clinical Andrology, 27, 21. https://doi.org/10.1186/s12610-017-0065-8

    Article  PubMed  PubMed Central  Google Scholar 

  • Haidl, G., & Schuppe, H.-C. (2006). Cytomorphological semen analysis. In W.-B. Schill, F. Comhaire, & T. B. Hargreave (Hrsg.), Andrology for the clinician (S. 555–560). Springer.

    Google Scholar 

  • Haidl, G., Allam, J.-P., Köhn, F.-M., Haidl, F., & Schuppe, H.-C. (2019). Medikamentöse Therapie primär nicht hormonell bedingter männlicher Fertilitätsstörungen. Gynäkologische Endokrinologie, 17, 236–244.

    Article  Google Scholar 

  • Hamilton, J. A., Cissen, M., Brandes, M., Smeenk, J. M., de Bruin, J. P., Kremer, J. A., Nelen, W. L., & Hamilton, C. J. (2015). Total motile sperm count: A better indicator for the severity of male factor infertility than the WHO sperm classification system. Human Reproduction, 30(5), 1110–1121.

    Article  CAS  PubMed  Google Scholar 

  • Hanson, B. M., Eisenberg, M. L., & Hotaling, J. M. (2018). Male infertility: A biomarker of individual and familial cancer risk. Fertility and Sterility, 109(1), 6–19.

    Article  CAS  PubMed  Google Scholar 

  • Henkel, R., Offor, U., & Fisher, D. (2021). The role of infections and leukocytes in male infertility. Andrologia, 53(1), e13743. https://doi.org/10.1111/and.13743

    Article  PubMed  Google Scholar 

  • Houston, B. J., Riera-Escamilla, A., Wyrwoll, M. J., et al. (2021). A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. Human Reproduction Update, dmab030. https://doi.org/10.1093/humupd/dmab030. Epub ahead of print.

  • Jakab, A., Sakkas, D., Delpiano, E., Cayli, S., Kovanci, E., Ward, D., Revelli, A., & Huszar, G. (2005). Intracytoplasmic sperm injection: A novel selection method for sperm with normal frequency of chromosomal aneuploidies. Fertility and Sterility, 84, 1665–1673.

    Article  PubMed  Google Scholar 

  • Jeschke, J. K., Biagioni, C., Schierling, T., Wagner, I. V., Börgel, F., Schepmann, D., Schüring, A., Kulle, A. E., Holterhus, P. M., von Wolff, M., Wünsch, B., Nordhoff, V., Strünker, T., & Brenker, C. (2021). The action of reproductive fluids and contained steroids, prostaglandins, and Zn2+ on CatSper Ca2+ channels in human sperm. Frontiers in Cell and Development Biology, 9, 699554. https://doi.org/10.3389/fcell.2021.699554

    Article  Google Scholar 

  • Jones, T. H., & Channer, K. S. (2012). Testosterone, obesity, diabetes and the metabolic syndrome. In E. Nieschlag & H. M. Behre (Hrsg.), Testosterone – Action, deficiency, substitution (4. Aufl., S. 235–250). Cambridge University Press.

    Chapter  Google Scholar 

  • Jungwirth, A., Diemer, T., Kopa, Z., Krausz, C., Mihas, S., & Tournaye, H. (2019). EAU Guidelines on male infertility. EAU Guidelines Office. http://uroweb.org/guideline/male-infertility. Zugegriffen am 28.05.2023.

  • Jurewicz, M., & Gilbert, B. R. (2016). Imaging and angiography in male factor infertility. Fertility and Sterility, 105(6), 1432–1442.

    Article  PubMed  Google Scholar 

  • Kamischke, A., & Nieschlag, E. (2002). Update on medical treatment of ejaculatory disorders. International Journal of Andrology, 25, 333–344.

    Article  CAS  PubMed  Google Scholar 

  • Kanakis, G. A., & Nieschlag, E. (2018). Klinefelter syndrome: More than hypogonadism. Metabolism, 86, 135–144.

    Article  CAS  PubMed  Google Scholar 

  • Keihani, S., Verrilli, L. E., Zhang, C., Presson, A. P., Hanson, H. A., Pastuszak, A. W., Johnstone, E. B., & Hotaling, J. M. (2021). Semen parameter thresholds and time-to-conception in subfertile couples: How high is high enough? Human Reproduction, 36(8), 2121–2133. https://doi.org/10.1093/humrep/deab133

    Article  PubMed  PubMed Central  Google Scholar 

  • Kliesch, S. (2020). Kryokonservierung von Spermien und Hodengewebe. In M. Balcarek et al. (Hrsg.), Indikation und Durchführung fertilitätsprotektiver Maßnahmen bei onkologischen und nicht-onkologischen Erkrankungen (2. Aufl., S. 291–306). Schmidt & Klaunig.

    Google Scholar 

  • Köhn, F.-M., & Schuppe, H. C. (2017). Fertilitätserhalt beim Mann. In T. Fehm et al. (Hrsg.), Fertilitätserhalt in der Gynäko-Onkologie (S. 47–56). De Gruyter.

    Google Scholar 

  • Köhn, F.-M., & Schuppe, H.-C. (2021). Der Einfluss von Umweltfaktoren und Lebensstil auf die männliche Fertilität. Gynakologe, 54, 260–272.

    Article  Google Scholar 

  • Köhn, F. M., Schuppe, H. C., Jung, A., & Schulze, W. (2005). Bedeutung der Hodenbiopsie in der Andrologie. Journal der Deutschen Dermatologischen Gesellschaft, 3, 532–557.

    Article  PubMed  Google Scholar 

  • Köhn, F. M., Schuppe, H. C., & Beier, K. M. (2015). Dermatologische Erkrankungen und Sexualität: Wie geht man vor? Hautarzt, 66(12), 907–912.

    Article  PubMed  Google Scholar 

  • Köhn, F.-M., Kliesch, S., Pinggera, G. M., Schuppe, H.-C., & Tüttelmann, F. (2020). Andrologische Diagnostik vor einer reproduktionsmedizinischen Behandlung. Urologe A, 59, 855–868.

    Article  PubMed  Google Scholar 

  • Koyuncu, H., Serefoglu, E. C., Ozdemir, A. T., & Hellstrom, W. J. (2012). Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation. International Journal of Impotence Research, 24(5), 171–173.

    Article  CAS  PubMed  Google Scholar 

  • Krause, W. K. H. (2008). Drugs compromising male sexual health. Springer.

    Google Scholar 

  • Krausz, C., & Riera-Escamilla, A. (2018). Genetics of male infertility. Nature Reviews. Urology, 15(6), 369–384. https://doi.org/10.1038/s41585-018-0003-3

    Article  CAS  PubMed  Google Scholar 

  • Krausz, C., Hoefsloot, L., Simoni, M., Tüttelmann, F., & European Academy of Andrology; European Molecular Genetics Quality Network. (2014). EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: State-of-the-art 2013. Andrology, 2(1), 5–19.

    Article  CAS  PubMed  Google Scholar 

  • Kroese, A. C., de Lange, N. M., Collins, J., et al. (2014). Surgery or embolization for varicoceles in subfertile men: Summary of a Cochrane review. Fertility and Sterility, 102, 1553–1555.

    Article  Google Scholar 

  • Lanfranco, F., Kamischke, A., Zitzmann, M., & Nieschlag, E. (2004). Klinefelter’s syndrome. Lancet, 364, 273–283.

    Article  CAS  PubMed  Google Scholar 

  • Latif, T., Kold Jensen, T., Mehlsen, J., Holmboe, S. A., Brinth, L., Pors, K., Skouby, S. O., Jørgensen, N., & Lindahl-Jacobsen, R. (2017). Semen quality as a predictor of subsequent morbidity: A Danish Cohort Study of 4,712 men with long-term follow-up. American Journal of Epidemiology, 186(8), 910–917.

    Article  PubMed  Google Scholar 

  • Le Tortorec, A., Matusali, G., Mahé, D., Aubry, F., Mazaud-Guittot, S., Houzet, L., & Dejucq-Rainsford, N. (2020). From ancient to emerging infections: The odyssey of viruses in the male genital tract. Physiological Reviews, 100, 1349–1414. https://doi.org/10.1152/physrev.00021.2019

    Article  PubMed  Google Scholar 

  • Leiber, C. (2017). Erektile Dysfunktion: Aktuelle Diagnostik und Therapie. Urologe A, 56(4), 519–529.

    Google Scholar 

  • Leisegang, K., Sengupta, P., Agarwal, A., & Henkel, R. (2021). Obesity and male infertility: Mechanisms and management. Andrologia, 53(1), e13617. https://doi.org/10.1111/and.13617

    Article  PubMed  Google Scholar 

  • Llavanera, M., Delgado-Bermúdez, A., Ribas-Maynou, J., Salas-Huetos, A., & Yeste, M. (2022). A systematic review identifying fertility biomarkers in semen: A clinical approach through Omics to diagnose male infertility. Fertility and Sterility, 118(2), 291–313. https://doi.org/10.1016/j.fertnstert.2022.04.028

    Article  CAS  PubMed  Google Scholar 

  • Lotti, F., & Maggi, M. (2015). Ultrasound of the male genital tract in relation to male reproductive health. Human Reproduction Update, 21(1), 56–83.

    Article  PubMed  Google Scholar 

  • Mallidis, C., Cooper, T. G., Hellenkemper, B., Lablans, M., Uckert, F., & Nieschlag, E. (2012). Ten years’ experience with an external quality control program for semen analysis. Fertility and Sterility, 98, 611–616.

    Article  PubMed  Google Scholar 

  • Marconi, M., Keudel, A., Diemer, T., Bergmann, M., Steger, K., Schuppe, H.-C., & Weidner, W. (2012). Combined trifocal- and micro-TESE is the best technique for testicular sperm retrieval in „low chance“ non-obstructive azoospermia. European Urology, 62(4), 713–719.

    Article  PubMed  Google Scholar 

  • Mascarenhas, M. N., Flaxman, S. R., Boerma, T., Vanderpoel, S., & Stevens, G. A. (2012). National, regional, and global trends in infertility prevalence since 1990: A systematic analysis of 277 health surveys. PLoS Medicine, 9, e1001356.

    Article  PubMed  PubMed Central  Google Scholar 

  • McLachlan, R. I., Rajpert-De Meyts, E. K., Hoei-Hansen, C. E., de Kretser, D. M., & Skakkebaek, N. E. (2007). Histological evaluation of the human testis – Approaches to optimizing the clinical value of the assessment: Mini review. Human Reproduction, 22, 2–16.

    Article  CAS  PubMed  Google Scholar 

  • Mehta, A., & Sigman, M. (2015). Management of the dry ejaculate: A systematic review of aspermia and retrograde ejaculation. Fertility and Sterility, 104(5), 1074–1081.

    Article  PubMed  Google Scholar 

  • Mittank-Weidner, T., Paasch, U., & Grunewald, S. (2019). Zu krank für eine Vaterschaft? Andrologische Beratung bei (neuen) onkologischen Systemtherapien. Gynäkologische Endokrinologie, 17, 245–249.

    Article  Google Scholar 

  • Molitch, M. E. (2017). Diagnosis and treatment of pituitary adenomas: A review. JAMA, 317(5), 516–524.

    Article  PubMed  Google Scholar 

  • Moreno-Sepulveda, J., & Rajmil, O. (2021). Seminal human papillomavirus infection and reproduction: A systematic review and meta-analysis. Andrology, 9, 478–502. https://doi.org/10.1111/andr.12948

    Article  PubMed  Google Scholar 

  • Muratori, M., Tamburrino, L., Marchiani, S., Cambi, M., Olivito, B., Azzari, C., Forti, G., & Baldi, E. (2015). Investigation on the origin of sperm DNA fragmentation: Role of apoptosis, immaturity and oxidative stress. Molecular Medicine, 21, 109–122.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muscianisi, F., De Toni, L., Giorato, G., Carosso, A., Foresta, C., & Garolla, A. (2021). Is HPV the novel target in male idiopathic infertility? A systematic review of the literature. Frontiers in Endocrinology (Lausanne), 12, 643539. https://doi.org/10.3389/fendo.2021.643539

    Article  Google Scholar 

  • Ni, K., Spiess, A. N., Schuppe, H. C., & Steger, K. (2016). The impact of sperm protamine deficiency and sperm DNA damage on human male fertility: A systematic review and meta-analysis. Andrology, 4(5), 789–799. https://doi.org/10.1111/andr.12216

    Article  CAS  PubMed  Google Scholar 

  • Nieschlag, E., & Lerchl, A. (2013). Sperm crisis: What crisis? Asian Journal of Andrology, 15(2), 184–186. https://doi.org/10.1038/aja.2012.90

    Article  PubMed  Google Scholar 

  • Nieschlag, E., Pock, T., & Hellenkemper, B. (2017). External quality control of semen analysis reveals low compliance with WHO guidelines. J Reproduktionsmed Endokrinologie, 14(6), 306–310.

    Google Scholar 

  • Noordam, M. J., & Repping, S. (2006). The human Y chromosome: A masculine chromosome. Current Opinion in Genetics & Development, 16, 225–232.

    Article  CAS  Google Scholar 

  • Nordhoff, V., & Kliesch, S. (2019). Das eine unter vielen – Spermienqualität und Möglichkeiten der Selektion. Gynäkologische Endokrinologie, 17, 250–256.

    Article  Google Scholar 

  • Nordhoff, V., Schüring, A. N., Krallmann, C., Zitzmann, M., Schlatt, S., Kiesel, L., & Kliesch, S. (2013). Optimizing TESE-ICSI by laser-assisted selection of immotile spermatozoa and polarization microscopy for selection of oocytes. Andrology, 1(1), 67–74.

    Article  CAS  PubMed  Google Scholar 

  • Olesen, I. A., Andersson, A. M., Aksglaede, L., Skakkebaek, N. E., Rajpert-de Meyts, E., Joergensen, N., & Juul, A. (2017). Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility. Fertility and Sterility, 107(1), 74–82.e7.

    Article  PubMed  Google Scholar 

  • Patat, O., Pagin, A., Siegfried, A., Mitchell, V., Chassaing, N., Faguer, S., Monteil, L., Gaston, V., Bujan, L., Courtade-Saïdi, M., Marcelli, F., Lalau, G., Rigot, J. M., Mieusset, R., & Bieth, E. (2016). Truncating mutations in the adhesion G protein-coupled receptor G2 gene ADGRG2 cause an X-linked congenital bilateral absence of vas deferens. American Journal of Human Genetics, 99(2), 437–442.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patel, B., Parets, S., Akana, M., Kellogg, G., Jansen, M., Chang, C., Cai, Y., Fox, R., Niknazar, M., Shraga, R., Hunter, C., Pollock, A., Wisotzkey, R., Jaremko, M., Bisignano, A., & Puig, O. (2018). Comprehensive genetic testing for female and male infertility using next-generation sequencing. Journal of Assisted Reproduction and Genetics, 35(8), 1489–1496.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pilatz, A., Hudemann, C., Wolf, J., Halefeld, I., Paradowska-Dogan, A., Schuppe, H. C., Hossain, H., Jiang, Q., Schultheiss, D., Renz, H., Weidner, W., Wagenlehner, F., & Linn, T. (2017). Metabolic syndrome and the seminal cytokine network in morbidly obese males. Andrology, 5(1), 23–30. https://doi.org/10.1111/andr.12296

    Article  CAS  PubMed  Google Scholar 

  • Punab, M., Poolamets, O., Paju, P., Vihljajev, V., Pomm, K., Ladva, R., Korrovits, P., & Laan, M. (2017). Causes of male infertility: A 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Human Reproduction, 32(1), 18–31. https://doi.org/10.1093/humrep/dew284

    Article  CAS  PubMed  Google Scholar 

  • Raivio, T., Falardeau, J., Dwyer, A., Quinton, R., Hayes, F. J., Hughes, V. A., Cole, L. W., Pearce, S. H., Lee, H., Boepple, P., Crowley, W. F., Jr., & Pitteloud, N. (2007). Reversal of idiopathic hypogonadotropic hypogonadism. The New England Journal of Medicine, 357(9), 863–873.

    Article  CAS  PubMed  Google Scholar 

  • Rajpert-De Meyts, E., McGlynn, K. A., Okamoto, K., Jewett, M. A., & Bokemeyer, C. (2016). Testicular germ cell tumours. Lancet, 387(10029), 1762–1774.

    Google Scholar 

  • Ramasamy, R., Ricci, J. A., Palermo, G. D., Gosden, L. V., Rosenwaks, Z., & Schlegel, P. N. (2009). Successful fertility treatment for Klinefelter’s syndrome. The Journal of Urology, 182, 1108–1113.

    Article  CAS  PubMed  Google Scholar 

  • Ribas-Maynou, J., Yeste, M., Becerra-Tomás, N., Aston, K. I., James, E. R., & Salas-Huetos, A. (2021). Clinical implications of sperm DNA damage in IVF and ICSI: Updated systematic review and meta-analysis. Biological Reviews of the Cambridge Philosophical Society, 96(4), 1284–1300. https://doi.org/10.1111/brv.12700

    Article  CAS  PubMed  Google Scholar 

  • Rohayem, J., Fricke, R., Czeloth, K., Mallidis, C., Wistuba, J., Krallmann, C., Zitzmann, M., & Kliesch, S. (2015). Age and markers of Leydig cell function, but not of Sertoli cell function predict the success of sperm retrieval in adolescents and adults with Klinefelter’s syndrome. Andrology, 3(5), 868–875.

    Article  CAS  PubMed  Google Scholar 

  • Rohayem, J., Sinthofen, N., Nieschlag, E., Kliesch, S., & Zitzmann, M. (2016a). Causes of hypogonadotropic hypogonadism predict response to gonadotropin substitution in adults. Andrology, 4(1), 87–94.

    Article  CAS  PubMed  Google Scholar 

  • Rohayem, J., Nieschlag, E., Zitzmann, M., & Kliesch, S. (2016b). Testicular function during puberty and young adulthood in patients with Klinefelter’s syndrome with and without spermatozoa in seminal fluid. Andrology, 4(6), 1178–1186.

    Article  CAS  PubMed  Google Scholar 

  • Rohayem, J., et al. (2017). Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine, 55(3), 914–924.

    Article  CAS  PubMed  Google Scholar 

  • Rowe, P. J., Comhaire, F. H., Hargreave, T. B., & Mahmoud, A. M. A. (2000). WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press.

    Google Scholar 

  • Rusz, A., Pilatz, A., Wagenlehner, F., Linn, T., Diemer, T., Schuppe, H.-C., Lohmeyer, J., Hossain, H., & Weidner, W. (2012). Influence of urogenital infections and inflammation on semen quality and male fertility. World Journal of Urology, 30, 23–30.

    Article  CAS  PubMed  Google Scholar 

  • Sakkas, D., Ramalingam, M., Garrido, N., & Barratt, C. L. (2015). Sperm selection in natural conception: What can we learn from Mother Nature to improve assisted reproduction outcomes? Human Reproduction Update, 21, 711–726.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Salonia, A., et al. (2021). European Association of Urology (EAU) guidelines on male sexual and reproductive health. http://uroweb.org/guidelines. Zugegriffen am 28.05.2023.

  • Sartorius, G. A., & Handelsman, D. (2009). Hypogonadismus und Infertilität bei systemischen Erkrankungen. In E. Nieschlag, H. M. Behre, & S. Nieschlag (Hrsg.), Andrologie – Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (3. Aufl., S. 340–364). Springer.

    Google Scholar 

  • Schlegel, P. N., Sigman, M., Collura, B., et al. (2021a). Diagnosis and treatment of infertility in men: AUA/ASRM guideline Part I. Fertility and Sterility, 115(1), 54–61.

    Article  PubMed  Google Scholar 

  • Schlegel, P. N., Sigman, M., Collura, B., et al. (2021b). Diagnosis and treatment of infertility in men: AUA/ASRM guideline Part II. Fertility and Sterility, 115(1), 62–69.

    Article  PubMed  Google Scholar 

  • Schubert, M., Pérez Lanuza, L., & Gromoll, J. (2019). Pharmacogenetics of FSH Action in the Male. Frontiers in Endocrinology (Lausanne), 10, 47. https://doi.org/10.3389/fendo.2019.0004

    Article  Google Scholar 

  • Schuppe, H.-C., & Köhn, F.-M. (2018). Andrologie. In G. Plewig et al. (Hrsg.), Braun-Falco’s Dermatologie, Venerologie und Allergologie (7. Aufl., S. 1547–1585). Springer.

    Chapter  Google Scholar 

  • Schuppe, H.-C., & Köhn, F.-M. (2022). Therapieversuche bei idiopathischer männlicher Subfertilität. In M. S. Michel, G. Janetschek, M. Wirth, & T. Sulser (Hrsg.), Die Urologie (2. Aufl.). Springer.

    Google Scholar 

  • Schuppe, H.-C., Jung, A., Ochsendorf, F. R., & Köhn, F.-M. (2014). Psoriasis und Partnerschaft – Andrologische Aspekte. Hautnah – dermatologie, 30(2), 105–111.

    Article  Google Scholar 

  • Schuppe, H.-C., Pilatz, A., Hossain, H., Diemer, T., Wagenlehner, F., & Weidner, W. (2017). Urogenitale Infektionen und männliche Fertilität. Deutsches Ärzteblatt International, 114, 339–346.

    PubMed  PubMed Central  Google Scholar 

  • Schuppe, H.-C., Köhn, F.-M., & Steger, K. (2019). Andrologie in der interdisziplinären Reproduktionsmedizin. In K. Diedrich et al. (Hrsg.), Reproduktionsmedizin (2. Aufl.). Springer Reference Medizin. https://doi.org/10.1007/978-3-662-55601-6_43-1

    Chapter  Google Scholar 

  • Schuppe, H.-C., Wyrwoll, M. J., Fietz, D., & Tüttelmann, F. (2022). Störungen der Spermato- und Spermiogenese. In E. Nieschlag, H. M. Behre, S. Kliesch, & S. Nieschlag (Hrsg.), Andrologie. Springer Reference Medizin. Springer.

    Google Scholar 

  • Schwarzer, J. U., & Schwarz, M. (2012). Significance of CFTR gene mutations in patients with congenital aplasia of vas deferens with special regard to renal aplasia. Andrologia, 44(5), 305–307.

    Article  CAS  PubMed  Google Scholar 

  • Semet, M., Paci, M., Saïas-Magnan, J., et al. (2017). The impact of drugs on male fertility: A review. Andrology, 5(4), 640–663.

    Article  CAS  PubMed  Google Scholar 

  • Sermondade, N., Faure, C., Fezeu, L., et al. (2013). BMI in relation to sperm count: An updated systematic review and collaborative meta-analysis. Human Reproduction Update, 19, 221–231.

    Article  CAS  PubMed  Google Scholar 

  • Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014). Antioxidants for male subfertility. Cochrane Database of Systematic Reviews, 12, CD007411.

    Google Scholar 

  • Sijstermans, K., Hack, W. W., Meijer, R. W., & van der Voort-Doedens, L. M. (2008). The frequency of undescended testis from birth to adulthood: A review. International Journal of Andrology, 31, 1–11.

    CAS  PubMed  Google Scholar 

  • Simoni, M., Tüttelmann, F., Gromoll, J., & Nieschlag, E. (2008). Clinical consequences of microdeletions of the Y chromosome: The extended Münster experience. Reproductive Biomedicine Online, 16, 289–303.

    Article  CAS  PubMed  Google Scholar 

  • Sironen, A., Shoemark, A., Patel, M., Loebinger, M. R., & Mitchison, H. M. (2020). Sperm defects in primary ciliary dyskinesia and related causes of male infertility. Cellular and Molecular Life Sciences, 77, 2029–2048.

    Article  CAS  PubMed  Google Scholar 

  • Skakkebaek, N. E., Rajpert-De Meyts, E., Buck Louis, G. M., Toppari, J., Andersson, A. M., Eisenberg, M. L., Jensen, T. K., Jørgensen, N., Swan, S. H., Sapra, K. J., Ziebe, S., Priskorn, L., & Juul, A. (2016). Male reproductive disorders and fertility trends: Influences of environment and genetic susceptibility. Physiological Reviews, 96(1), 55–97.

    Article  CAS  PubMed  Google Scholar 

  • Snick, H. K., Snick, T. S., Evers, J. L., & Collins, J. A. (1997). The spontaneous pregnancy prognosis in untreated subfertile couples: The Walcheren primary care study. Human Reproduction, 12, 1582–1588.

    Article  CAS  PubMed  Google Scholar 

  • Stalf, T., Mehnert, C., Hajimohammad, A., Manolopoulos, S. Y., Schuppe, H.-C., Diemer, T., Schill, W.-B., Weidner, W., & Tinneberg, H.-R. (2005). Influence of motility and vitality on intracytoplasmic sperm injection with ejaculated and testicular spermatozoa. Andrologia, 37, 125–130.

    Article  CAS  PubMed  Google Scholar 

  • van der Steeg, J. W., Steures, P., Eijkemans, M. J., Habbema, J. D. F., Hompes, P. G., Kremer, J. A., van der Leeuw-Harmsen, L., Bossuyt, P. M., Repping, S., Silber, S. J., Mol, B. W., van der Veen, F., & Collaborative Effort for Clinical Evaluation in Reproductive Medicine Study Group. (2011). Role of semen analysis in subfertile couples. Fertility and Sterility, 95, 1013–1019.

    Article  PubMed  Google Scholar 

  • Steger, K., Cavalcanti, M. C., & Schuppe, H. C. (2011). Prognostic markers for competent human spermatozoa: Fertilizing capacity and contribution to the embryo. International Journal of Andrology, 34, 513–527.

    Article  CAS  PubMed  Google Scholar 

  • Stouffs, K., Vloeberghs, V., Gheldof, A., Tournaye, H., & Seneca, S. (2017). Are AZFb deletions always incompatible with sperm production? Andrology, 5(4), 691–694.

    Article  CAS  PubMed  Google Scholar 

  • Stukenborg, J. B., Alves-Lopes, J. P., Kurek, M., Albalushi, H., Reda, A., Keros, V., Töhönen, V., Bjarnason, R., Romerius, P., Sundin, M., Norén Nyström, U., Langenskiöld, C., Vogt, H., Henningsohn, L., Mitchell, R. T., Söder, O., Petersen, C., & Jahnukainen, K. (2018). Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy. Human Reproduction, 33(9), 1677–1683.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Taiyeb, A. M., Ridha-Albarzanchi, M. T., Taiyeb, S. M., Kanan, Z. A., Alatrakchi, S. K., Kjelland, M. E., & Muhsen-Alanssari, S. A. (2017). Improvement in pregnancy outcomes in couples with immunologically male infertility undergoing prednisolone treatment and conventional in vitro fertilization preceded by sperm penetration assay: A randomized controlled trial. Endocrine, 58, 448–457.

    Article  CAS  PubMed  Google Scholar 

  • Tiepolo, L., & Zuffardi, O. (1976). Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Human Genetics, 34, 119–124.

    Article  CAS  PubMed  Google Scholar 

  • Tosti, E., & Ménézo, Y. (2016). Gamete activation: Basic knowledge and clinical applications. Human Reproduction Update, 22(4), 420–439.

    Article  PubMed  PubMed Central  Google Scholar 

  • Toth, B., et al. (2019). Diagnostik und Therapie vor einer assistierten reproduktionsmedizinischen Behandlung (ART). S2k-Leitlinie, AWMF-Register Nr. 015/085, 02/2019. https://www.awmf.org/leitlinien/detail/ll/015-085.html. Zugegriffen am 28.05.2023.

  • Tournaye, H., Krausz, C., & Oates, R. D. (2017a). Novel concepts in the aetiology of male reproductive impairment. The Lancet Diabetes and Endocrinology, 5(7), 544–553.

    Article  PubMed  Google Scholar 

  • Tournaye, H., Krausz, C., & Oates, R. D. (2017b). Concepts in diagnosis and therapy for male reproductive impairment. The Lancet Diabetes and Endocrinology, 5(7), 554–564.

    Article  PubMed  Google Scholar 

  • Tüttelmann, F., & Gromoll, J. (2010). Novel genetic aspects of Klinefelter’s syndrome. Molecular Human Reproduction, 16(6), 386–395.

    Article  PubMed  Google Scholar 

  • Tüttelmann, F., & Nieschlag, E. (2009). Nosologie andrologischer Krankheitsbilder. In E. Nieschlag, H. M. Behre, & S. Nieschlag (Hrsg.), Andrologie – Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (3. Aufl., S. 90–96). Springer.

    Google Scholar 

  • Tüttelmann, F., Werny, F., Cooper, T. G., Kliesch, S., Simoni, M., & Nieschlag, E. (2011). Clinical experience with azoospermia: Aetiology and chances for spermatozoa detection upon biopsy. International Journal of Andrology, 34, 291–298.

    Article  PubMed  Google Scholar 

  • Tüttelmann, F., Ruckert, C., & Röpke, A. (2018). Disorders of spermatogenesis. Medizinische Genetik, 30(1), 12–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Virtanen, H. E., & Toppari, J. (2015). Cryptorchidism and fertility. Endocrinology and Metabolism Clinics of North America, 44(4), 751–760.

    Article  PubMed  Google Scholar 

  • van Voorhis, B. J., Barnett, M., Sparks, A. E., Syrop, C. H., Rosenthal, G., & Dawson, J. (2001). Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. Fertility and Sterility, 75, 661–668.

    Article  PubMed  Google Scholar 

  • Vorona, E., Zitzmann, M., Gromoll, J., Schüring, A. N., & Nieschlag, E. (2007). Clinical, endocrinological, and epigenetic features of the 46,XX male syndrome, compared with 47,XXY Klinefelter patients. The Journal of Clinical Endocrinology and Metabolism, 92(9), 3458–3465.

    Article  CAS  PubMed  Google Scholar 

  • Wagenlehner, F. M. E., Naber, K. G., Bschleipfer, T., Brähler, E., & Weidner, W. (2009). Prostatitis und männliches Beckenschmerzsyndrom: Diagnostik und Therapie. Deutsches Ärzteblatt International, 106, 175–183.

    PubMed  PubMed Central  Google Scholar 

  • Walsh, T. J., Croughan, M. S., Schembri, M., Chan, J. M., & Turek, P. J. (2009). Increased risk of testicular germ cell cancer among infertile men. Archives of Internal Medicine, 169, 351–356.

    Article  PubMed  PubMed Central  Google Scholar 

  • Warne, D. W., Decosterd, G., Okada, H., Yano, Y., Koide, N., & Howles, C. M. (2009). A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin. Fertility and Sterility, 92, 594–604.

    Article  CAS  PubMed  Google Scholar 

  • Weidner, W. H. G., Schuppe, H.-C., Pilatz, A., et al. (2014). Sperm cells for artificial reproduction and germ cell transplantation. European Urology Supplements, 13, 83–88.

    Article  Google Scholar 

  • Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021). Sexually transmitted infections treatment guidelines. MMWR – Recommendations and Reports, 23, 701–187. https://doi.org/10.15585/mmwr.rr7004a1

    Article  Google Scholar 

  • World Health Organization. (1999). WHO-Laborhandbuch zur Untersuchung des menschlichen Ejakulates und der Spermien-Zervikalschleim-Interaktion (4. Aufl.). Springer.

    Google Scholar 

  • World Health Organization. (2010). WHO laboratory manual for the examination and processing of human semen (5. Aufl.). WHO Press.

    Google Scholar 

  • World Health Organization. (2021). WHO laboratory manual for the examination and processing of human semen (6. Aufl.). WHO Press.

    Google Scholar 

  • Wu, Q. Y., Li, N., Li, W. W., Li, T. F., Zhang, C., Cui, Y. X., Xia, X. Y., & Zhai, J. S. (2014). Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive. BMC Urology, 14, 70.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wyrwoll, M. J., Köckerling, N., Vockel, M., Dicke, A. K., Rotte, N., Pohl, E., Emich, J., Wöste, M., Ruckert, C., Wabschke, R., Seggewiss, J., Ledig, S., Tewes, A. C., Stratis, Y., Cremers, J. F., Wistuba, J., Krallmann, C., Kliesch, S., Röpke, A., Stallmeyer, B., Friedrich, C., & Tüttelmann, F. (2022) Genetic architecture of azoospermia-time to advance the standard of care. European Urology, S0302-2838(22)02384-3. https://doi.org/10.1016/j.eururo.2022.05.011. Epub ahead of print.

  • Yu, J., Chen, Z., Ni, Y., & Li, Z. (2012). CFTR mutations in men with congenital bilateral absence of the vas deferens (CBAVD): A systemic review and meta-analysis. Human Reproduction, 27(1), 25–35.

    Article  CAS  PubMed  Google Scholar 

  • Zitzmann, M. (2020). Testosteronersatztherapie des Mannes – neue Standpunkte. J Reproduktionsmed Endokrinologie, 17(2), 86–94.

    Google Scholar 

  • Zitzmann, M., Aksglaede, L., Corona, G., Isidori, A. M., Juul, A., T’Sjoen, G., Kliesch, S., D’Hauwers, K., Toppari, J., Słowikowska-Hilczer, J., Tüttelmann, F., & Ferlin, A. (2021). European academy of andrology guidelines on Klinefelter Syndrome Endorsing Organization: European Society of Endocrinology. Andrology, 9, 145–167.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Sektion Konservative Andrologie/Kryobank an der Klinik und Poliklinik für Urologie, Kinderurologie, Universitätsklinikum Gießen und Marburg GmbH, Gießen, Deutschland

    Hans-Christian Schuppe

  2. Andrologicum München, München, Deutschland

    Frank-Michael Köhn

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  1. Hans-Christian Schuppe
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  2. Frank-Michael Köhn
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Correspondence to Hans-Christian Schuppe .

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  1. TFP-Kinderwunschzentrum Wiesbaden, MVZ Wiesbaden GmbH, Wiesbaden, Deutschland

    Michael Amrani

  2. TFP-Kinderwunschzentrum Wiesbaden, MVZ Wiesbaden GmbH, Wiesbaden, Deutschland

    Rudolf Seufert

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© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

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Schuppe, HC., Köhn, FM. (2023). Andrologie für die gynäkologische Praxis. In: Amrani, M., Seufert, R. (eds) Gynäkologische Endokrinologie und Kinderwunschtherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65371-5_6

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  • DOI: https://doi.org/10.1007/978-3-662-65371-5_6

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