Zusammenfassung
Die Gesamtheit der Mikroorganismen, mit denen wir Menschen besiedelt sind, wird als Mikrobiota bezeichnet. Die symbiotischen Interaktionen zwischen der Mikrobiota und ihrem Wirt, die sich auf allen Körperoberflächen abspielen, dienen der Aufrechterhaltung unserer Körperfunktionen und sind von wesentlicher Bedeutung für einen gesunden Organismus, aber auch für die Entstehung von Krankheiten. Die Mikrobiota des Menschen beheimatet neben einer großen Anzahl an Bakterien auch Viren, Protozoen, Pilze und Archaebakterien, wobei der Gastrointestinaltrakt das am dichtesten besiedelte Organ des Menschen ist. Daher wird verständlich, dass Störungen im Gleichgewicht der Mikrobiota (Dysbiose) mit zahlreichen Magen-Darm-Erkrankungen verbunden sind und die Behandlung einer Dysbiose somit ein Therapieziel darstellt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
Literatur
Clooney AG, Sutton TDS, Shkoporov AN, Holohan RK, Daly KM, O'Regan O, Ryan FJ, Draper LA, Plevy SE, Ross RP, Hill C (2019) Whole-virome analysis sheds light on viral dark matter in inflammatory bowel disease. Cell Host Microbe 26:764–78 e5
Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J (2019) Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut 68:654–662
De Hertogh G, Aerssens J, Geboes KP, Geboes K (2008) Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease. World J Gastroenterol 14:845–852
Feagins LA, Holubar SD, Kane SV, Spechler SJ (2011) Current strategies in the management of intra-abdominal abscesses in Crohn's disease. Clin Gastroenterol Hepatol 9:842–850
Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14:491–502
Hagel S, Fischer A, Ehlermann P, Frank T, Tueffers K, Sturm A, Link A, Demir M, Siebenhaar A, Storr M, Glueck T, Siegel E, Solbach P, Goeser F, Koelbel CB, Lohse A, Luebbert C, Kandzi U, Maier M, Schuerle S, Lerch MM, Tacke D, Cornely OA, Stallmach A, Vehreschild M, Group German Clinical Microbiome Study (2016) Fecal microbiota transplant in patients with recurrent Clostridium difficile infection. Dtsch Arztebl Int 113:583–589
Harper PH, Truelove SC, Lee EC, Kettlewell MG, Jewell DP (1983) Split ileostomy and ileocolostomy for Crohn's disease of the colon and ulcerative colitis: a 20 year survey. Gut 24:106–113
Hartong WA, Arvanitakis C, Skibba RM, Klotz AP (1977) Treatment of toxic megacolon. A comparative review of 29 patients. Am J Dig Dis 22:195–200
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11:506–514
Hoffmann RM, Kruis W (2002) Probiotics and prebiotics – a renaissance? Internist (Berl) 43:1400–1406
Kalischuk LD, Buret AG (2010) A role for Campylobacter jejuni-induced enteritis in inflammatory bowel disease? Am J Physiol Gastrointest Liver Physiol 298:G1–G9
Kostic AD, Xavier RJ, Gevers D (2014) The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146:1489–1499
Kundu P, Blacher E, Elinav E, Pettersson S (2017) Our gut microbiome: the evolving inner self. Cell 171:1481–1493
Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375:2369–2379
Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, Lee CH (2015) Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149(102-09):e6
Nagalingam NA, Lynch SV (2012) Role of the microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 18:968–984
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG (2018) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390:2769–2778
Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R, Xuan W, Lin E, Mitchell HM, Borody TJ (2017a) Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 389:1218–1228
Paramsothy S, Paramsothy R, Rubin DT, Kamm MA, Kaakoush NO, Mitchell HM, Castano-Rodriguez N (2017b) Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 11:1180–1199
Sender R, Fuchs S, Milo R (2016) Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164:337–340
Sokol H, Leducq V, Aschard H, Pham HP, Jegou S, Landman C, Cohen D, Liguori G, Bourrier A, Nion-Larmurier I, Cosnes J, Seksik P, Langella P, Skurnik D, Richard ML, Beaugerie L (2017) Fungal microbiota dysbiosis in IBD. Gut 66:1039–1048
Stallmach A, Carstens O (2002) Role of infections in the manifestation or reactivation of inflammatory bowel diseases. Inflamm Bowel Dis 8:213–218
Stallmach A, Lange K, Buening J, Sina C, Vital M, Pieper DH (2016) Fecal microbiota transfer in patients with chronic antibiotic-refractory pouchitis. Am J Gastroenterol 111:441–443
Stallmach A, Steube A, Grunert P, Hartmann M, Biehl LM, Vehreschild M (2020) Fecal microbiota transfer. Dtsch Arztebl Int 117:31–38
Steube A, Vital M, Grunert P, Pieper DH, Stallmach A (2019) Long-term multidonor faecal microbiota transfer by oral capsules for active ulcerative colitis. J Crohns Colitis 13:1480–1481
West RL, van der Woude CJ, Hansen BE, Felt-Bersma RJ, van Tilburg AJ, Drapers JA, Kuipers EJ (2004) Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn's disease with infliximab: a double-blind placebo-controlled study. Aliment Pharmacol Ther 20:1329–1336
Youngster I, Mahabamunuge J, Systrom HK, Sauk J, Khalili H, Levin J, Kaplan JL, Hohmann EL (2016) Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection. BMC Med 14:134
Zoetendal EG, von Wright A, Vilpponen-Salmela T, Ben-Amor K, Akkermans AD, de Vos WM (2002) Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces. Appl Environ Microbiol 68:3401–3407
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature
About this chapter
Cite this chapter
Stallmach, A., Steube, A., Schauer, A. (2023). Mikrobiota, Präbiotika, Antibiotika und fäkaler Mikrobiota-Transfer. In: Sturm, A. (eds) Pflege bei chronisch-entzündlichen Darmerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64938-1_3
Download citation
DOI: https://doi.org/10.1007/978-3-662-64938-1_3
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-64937-4
Online ISBN: 978-3-662-64938-1
eBook Packages: Medicine (German Language)