Skip to main content

Mikrobiota, Präbiotika, Antibiotika und fäkaler Mikrobiota-Transfer

  • Chapter
  • First Online:
Pflege bei chronisch-entzündlichen Darmerkrankungen

Zusammenfassung

Die Gesamtheit der Mikroorganismen, mit denen wir Menschen besiedelt sind, wird als Mikrobiota bezeichnet. Die symbiotischen Interaktionen zwischen der Mikrobiota und ihrem Wirt, die sich auf allen Körperoberflächen abspielen, dienen der Aufrechterhaltung unserer Körperfunktionen und sind von wesentlicher Bedeutung für einen gesunden Organismus, aber auch für die Entstehung von Krankheiten. Die Mikrobiota des Menschen beheimatet neben einer großen Anzahl an Bakterien auch Viren, Protozoen, Pilze und Archaebakterien, wobei der Gastrointestinaltrakt das am dichtesten besiedelte Organ des Menschen ist. Daher wird verständlich, dass Störungen im Gleichgewicht der Mikrobiota (Dysbiose) mit zahlreichen Magen-Darm-Erkrankungen verbunden sind und die Behandlung einer Dysbiose somit ein Therapieziel darstellt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 49.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Clooney AG, Sutton TDS, Shkoporov AN, Holohan RK, Daly KM, O'Regan O, Ryan FJ, Draper LA, Plevy SE, Ross RP, Hill C (2019) Whole-virome analysis sheds light on viral dark matter in inflammatory bowel disease. Cell Host Microbe 26:764–78 e5

    Article  CAS  Google Scholar 

  • Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J (2019) Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut 68:654–662

    Article  CAS  Google Scholar 

  • De Hertogh G, Aerssens J, Geboes KP, Geboes K (2008) Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease. World J Gastroenterol 14:845–852

    Article  Google Scholar 

  • Feagins LA, Holubar SD, Kane SV, Spechler SJ (2011) Current strategies in the management of intra-abdominal abscesses in Crohn's disease. Clin Gastroenterol Hepatol 9:842–850

    Article  Google Scholar 

  • Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14:491–502

    Article  Google Scholar 

  • Hagel S, Fischer A, Ehlermann P, Frank T, Tueffers K, Sturm A, Link A, Demir M, Siebenhaar A, Storr M, Glueck T, Siegel E, Solbach P, Goeser F, Koelbel CB, Lohse A, Luebbert C, Kandzi U, Maier M, Schuerle S, Lerch MM, Tacke D, Cornely OA, Stallmach A, Vehreschild M, Group German Clinical Microbiome Study (2016) Fecal microbiota transplant in patients with recurrent Clostridium difficile infection. Dtsch Arztebl Int 113:583–589

    Google Scholar 

  • Harper PH, Truelove SC, Lee EC, Kettlewell MG, Jewell DP (1983) Split ileostomy and ileocolostomy for Crohn's disease of the colon and ulcerative colitis: a 20 year survey. Gut 24:106–113

    Article  CAS  Google Scholar 

  • Hartong WA, Arvanitakis C, Skibba RM, Klotz AP (1977) Treatment of toxic megacolon. A comparative review of 29 patients. Am J Dig Dis 22:195–200

    Article  CAS  Google Scholar 

  • Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11:506–514

    Article  Google Scholar 

  • Hoffmann RM, Kruis W (2002) Probiotics and prebiotics – a renaissance? Internist (Berl) 43:1400–1406

    Article  CAS  Google Scholar 

  • Kalischuk LD, Buret AG (2010) A role for Campylobacter jejuni-induced enteritis in inflammatory bowel disease? Am J Physiol Gastrointest Liver Physiol 298:G1–G9

    Article  CAS  Google Scholar 

  • Kostic AD, Xavier RJ, Gevers D (2014) The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146:1489–1499

    Article  CAS  Google Scholar 

  • Kundu P, Blacher E, Elinav E, Pettersson S (2017) Our gut microbiome: the evolving inner self. Cell 171:1481–1493

    Article  CAS  Google Scholar 

  • Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375:2369–2379

    Article  CAS  Google Scholar 

  • Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, Lee CH (2015) Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149(102-09):e6

    Google Scholar 

  • Nagalingam NA, Lynch SV (2012) Role of the microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 18:968–984

    Article  Google Scholar 

  • Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG (2018) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390:2769–2778

    Article  Google Scholar 

  • Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R, Xuan W, Lin E, Mitchell HM, Borody TJ (2017a) Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 389:1218–1228

    Article  Google Scholar 

  • Paramsothy S, Paramsothy R, Rubin DT, Kamm MA, Kaakoush NO, Mitchell HM, Castano-Rodriguez N (2017b) Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 11:1180–1199

    Article  Google Scholar 

  • Sender R, Fuchs S, Milo R (2016) Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164:337–340

    Article  CAS  Google Scholar 

  • Sokol H, Leducq V, Aschard H, Pham HP, Jegou S, Landman C, Cohen D, Liguori G, Bourrier A, Nion-Larmurier I, Cosnes J, Seksik P, Langella P, Skurnik D, Richard ML, Beaugerie L (2017) Fungal microbiota dysbiosis in IBD. Gut 66:1039–1048

    Article  CAS  Google Scholar 

  • Stallmach A, Carstens O (2002) Role of infections in the manifestation or reactivation of inflammatory bowel diseases. Inflamm Bowel Dis 8:213–218

    Article  Google Scholar 

  • Stallmach A, Lange K, Buening J, Sina C, Vital M, Pieper DH (2016) Fecal microbiota transfer in patients with chronic antibiotic-refractory pouchitis. Am J Gastroenterol 111:441–443

    Article  Google Scholar 

  • Stallmach A, Steube A, Grunert P, Hartmann M, Biehl LM, Vehreschild M (2020) Fecal microbiota transfer. Dtsch Arztebl Int 117:31–38

    Google Scholar 

  • Steube A, Vital M, Grunert P, Pieper DH, Stallmach A (2019) Long-term multidonor faecal microbiota transfer by oral capsules for active ulcerative colitis. J Crohns Colitis 13:1480–1481

    Article  Google Scholar 

  • West RL, van der Woude CJ, Hansen BE, Felt-Bersma RJ, van Tilburg AJ, Drapers JA, Kuipers EJ (2004) Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn's disease with infliximab: a double-blind placebo-controlled study. Aliment Pharmacol Ther 20:1329–1336

    Article  CAS  Google Scholar 

  • Youngster I, Mahabamunuge J, Systrom HK, Sauk J, Khalili H, Levin J, Kaplan JL, Hohmann EL (2016) Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection. BMC Med 14:134

    Article  Google Scholar 

  • Zoetendal EG, von Wright A, Vilpponen-Salmela T, Ben-Amor K, Akkermans AD, de Vos WM (2002) Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces. Appl Environ Microbiol 68:3401–3407

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andreas Stallmach .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Stallmach, A., Steube, A., Schauer, A. (2023). Mikrobiota, Präbiotika, Antibiotika und fäkaler Mikrobiota-Transfer. In: Sturm, A. (eds) Pflege bei chronisch-entzündlichen Darmerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64938-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-64938-1_3

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-64937-4

  • Online ISBN: 978-3-662-64938-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics