Zusammenfassung
Demenz (ICD-10-Code: F00-F03) zeichnet ein klinisches Syndrom als Folge einer meist chronischen oder fortschreitenden Erkrankung des Gehirns mit Störung vieler höherer kortikaler Funktionen, wie zum Beispiel Gedächtnis, Denken, Orientierung, Auffassung, Rechnen, Sprache und Urteilsvermögen. Das Bewusstsein ist nicht getrübt. Meist sind die kognitiven Veränderungen begleitet von Veränderungen der emotionalen Kontrolle und des Sozialverhaltens (siehe Tabelle 6.1).
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Literatur
Albert MS et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:270–279
Altmann A et al (2014) Sex Modifies the APOE-Related Risk of Developing Alzheimer Disease. Ann Neurol 75:563–573
Bateman RJ et al (2012) Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease. N Engl J Med 367:795–804. https://doi.org/10.1056/NEJMoa1202753
Birks J., Grimley EV, Van Dongen M (2002) Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 4, CD003120.
Braak H et al (1995) Staging of Alzheimers disease related neurodibrillary changes. Neurobiol Aging 16:271–284
Crutch SJ et al (2013) Shining a light on posterior cortical atrophy. Alzheimers Dement 9:463–465
Devenney EM et al (2019) Frontotemporal dementia. Handb Clin Neurol 167:279–299
Elahi FM (2017) A clinicopathological approach to the diagnosis of dementia. Nature Rev Neurol 13:457–476. https://doi.org/10.1038/nrneurol.2017.96
Emre M et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord 22:1689–1707
Galasko DR et al (2017) CSF biomarkers for Alzheimer disease — approaching consensus. Nat Rev Neurol 13:131–132
Goldman JS, Van Deerlin VM (2018) Alzheimer’s disease and frontotemporal dementia: the current state of genetics and genetic testing since the advent of next-generation sequencing. Mol Diagn Ther 22:505–513
Goodman RA (2017) Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011–2013. Alzheimers Dement 13:28–37
Gorno-Tempini ML et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76:1006–1014
Hogan DB et al (2016) The prevalence and incidence of frontotemporal dementia: a systematic review. Can J Neurol Sci 43. Suppl 1:S96–S109. https://doi.org/10.1017/cjn.2016.25
Howard R et al (2015) Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer’s Disease (DOMINO-AD) trial: secondary and post-hoc analyses. Lancet Neurol 14:1171–1181
Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme 10. Revision, German Modification, Version 2020.
Inouye SK et al (2014) Delirium in elderly people. Lancet 383(9920):911–922
Irwin D et al (2012) Neuropathologic substrates of Parkinson disease dementia. Ann Neurol 72:587–598
Jack CR et al (2018) NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimer Dement 14:535–562
Jeppsson A et al (2013) Idiopathic normal pressure hydrocephalus. Neurology 80:1385–1392
Kovacs GG et al (2013) Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series. Acta Neuropathol 126:365–384. https://doi.org/10.1007/s00401-013-1157-y
Livingston G. et al. (2017) Dementia prevention, intervention, and care. Lancet 380, 390(10113), 2673–2734.
Liu C et al (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy. Nat Rev Neurol 9:106–118. https://doi.org/10.1038/nrneurol.2012.263
Lobo AMD (2000) Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly ResearchGroup. Neurology 54. Supplement 5:S4–S9
Lopez O.L., Kuller L.H. (2019) Epidemiology of aging and associated cognitive disorders: Prevalence and incidence of Alzheimer's disease and other dementias.
Handb Clin Neurol 167,139–148.
Lott IT et al (2019) Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol 15:135–147
Ossenkoppele R et al (2015) The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features. Brain 138:2732–2749
McKeith IG et al (2017) Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 89:88–100
McKeith IG et al (2020) Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology 94:743–755
McKhann GM et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:263–269
McShane R. (2006) Memantine for dementia. Cochrane Database Syst Rev 2006 2,CD003154.
Mendez MF et al (2012) Nonamnestic presentations of early-onset Alzheimer’s disease. Am. J. Alzheimers Dis Other Demen 27:413–420
Mitchell AJ et al (2009) Rate of progression of mild cognitive impairment to dementia–meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 119:252–265
Molinuevo JL et al (2018) Current state of Alzheimer’s fluid biomarkers. Acta Neuropathol 136:821–853
Neary D et al (2005) Frontotemporal dementia. Lancet Neurol 4:771–780
Ngandu T et al (2015) A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 9984:2255–2263
Nichols E et al (2019) Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study. Lancet Neurol 18:88–106
Paradise MB, Sachdev PS (2019) Vascular Cognitive Disorder. Semin Neurol 39:241–250
Petersen RC et al (2001) Practice parameter: early detection of dementia: mild cognitive impairment (an evidence based review). Neurology 96:1133–1142
Petersen RC et al (2014) Mild cognitive impairment: a concept in evolution. J Internal Medicine 275:214–228
Ratnavalli E et al (2002) The prevalence of frontotemporal dementia. Neurology 58:1615–1621
Ridley N et al (2013) Alcohol-related dementia: an update of the evidence. Alzheimers Res Ther 5:3
Sachdev PS et al (2014) Classifying neurocognitive disorders: the DSM-5 approach. Nat Rev Neurol 10:634–642
Selkoe D et al (2016) The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Molecular Medicine 8:6
Skrobot O.A. et al; VICCCS group (2018) Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimers Dement 14, 280–292.
Stevens T et al (2002) Islington study of dementia subtypes in the community. Br J Psychiatry 180:270–276
Tanzi RE et al (2005) Twenty years of the Alzheimer’s Review Disease Amyloid Hypothesis: A genetic perspective. Cell 120:545–555. https://doi.org/10.1016/j.cell.2005.02.008
Thal RD et al (2002) Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791–1800
Zaccai J et al (2005) A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing 34:561–566. https://doi.org/10.1093/ageing/afi190
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Stögmann, E., Hilger, E., Pirker, W. (2021). Klinik der Demenzen. In: Schloffer, H., Prang, E., Frick-Salzmann, A. (eds) Gedächtnistraining. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-62300-8_6
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