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Osteochondral Repair Using a Hybrid Implant Composed of Stem Cells and Biomaterial

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Abstract

Osteoarthritis (OA) is a common disease, which could potentially affect the quality of life of both young and elderly populations worldwide. The management of OA remains challenging and controversial. Although there are several clinical options for the treatment of OA, it has proven difficult to restore the damaged articular cartilage due to the limited healing capacity. With the advancements in tissue engineering approaches including cell-based technologies and development of biomaterial scaffolds over the past decade, new therapeutic options for patients with osteochondral lesions may be potentially available. This chapter will highlight the current techniques and recent advances of tissue-engineered biomaterial scaffolds, which can mimic the native osteochondral complex, for osteochondral tissue regeneration. Moreover, we will introduce our novel technique using a hybrid implant composed of artificial bone coupled with a mesenchymal stem cell (MSC)–based scaffold-free tissue-engineered construct (TEC) and show its feasibility for osteochondral repair.

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Acknowledgments

This study was supported by a grant from the New Energy and Industrial Technology Development Organization, Japan, and Grant-in-Aid for Scientific Research (B), Japan Society for the promotion of Science, Japan.

Author information

Authors and Affiliations

  1. Medicine for Sports and Performing Arts, Department of Health and Sport Sciences, Osaka University Graduate School of Medicine, Osaka, Japan

    Kazunori Shimomura M.D., Ph.D.

  2. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Kazunori Shimomura M.D., Ph.D. & Hideki Yoshikawa M.D., Ph.D.

  3. Faculty of System Design, Tokyo Metropolitan University, Tokyo, Japan

    Hiromichi Fujie Ph.D.

  4. Research Institute for Science and Technology, Kogakuin University, Tokyo, Japan

    Hiromichi Fujie Ph.D.

  5. McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada

    David A. Hart Ph.D.

  6. Institute for Medical Science in Sports, Osaka Health Science University, 1-9-27, Tenma, Kita-ku, Osaka City, Osaka, 530-0043, Japan

    Norimasa Nakamura M.D., Ph.D.

  7. Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan

    Norimasa Nakamura M.D., Ph.D.

Authors
  1. Kazunori Shimomura M.D., Ph.D.
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  2. Hiromichi Fujie Ph.D.
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  3. David A. Hart Ph.D.
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  4. Hideki Yoshikawa M.D., Ph.D.
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  5. Norimasa Nakamura M.D., Ph.D.
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Corresponding author

Correspondence to Norimasa Nakamura M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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© 2017 ISAKOS

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Shimomura, K., Fujie, H., Hart, D.A., Yoshikawa, H., Nakamura, N. (2017). Osteochondral Repair Using a Hybrid Implant Composed of Stem Cells and Biomaterial. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_53

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  • DOI: https://doi.org/10.1007/978-3-662-54181-4_53

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54180-7

  • Online ISBN: 978-3-662-54181-4

  • eBook Packages: MedicineMedicine (R0)

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