Abstract
Osteoarthritis (OA) is a common disease, which could potentially affect the quality of life of both young and elderly populations worldwide. The management of OA remains challenging and controversial. Although there are several clinical options for the treatment of OA, it has proven difficult to restore the damaged articular cartilage due to the limited healing capacity. With the advancements in tissue engineering approaches including cell-based technologies and development of biomaterial scaffolds over the past decade, new therapeutic options for patients with osteochondral lesions may be potentially available. This chapter will highlight the current techniques and recent advances of tissue-engineered biomaterial scaffolds, which can mimic the native osteochondral complex, for osteochondral tissue regeneration. Moreover, we will introduce our novel technique using a hybrid implant composed of artificial bone coupled with a mesenchymal stem cell (MSC)–based scaffold-free tissue-engineered construct (TEC) and show its feasibility for osteochondral repair.
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This study was supported by a grant from the New Energy and Industrial Technology Development Organization, Japan, and Grant-in-Aid for Scientific Research (B), Japan Society for the promotion of Science, Japan.
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Shimomura, K., Fujie, H., Hart, D.A., Yoshikawa, H., Nakamura, N. (2017). Osteochondral Repair Using a Hybrid Implant Composed of Stem Cells and Biomaterial. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_53
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