Skip to main content
SpringerLink
Log in

Adulte Stammzellen des Fettgewebes in der regenerativen Medizin

  • Chapter
  • First Online:
Plastische Chirurgie

  • 4297 Accesses

Zusammenfassung

Die Korrektur von Konturunregelmäßigkeiten und Volumendefiziten des Weichteilgewebes stellt nach wie vor eine Herausforderung in der Plastischen Chirurgie dar. Klinische Indikationen zur Rekonstruktion bzw. Substitution von Weichteilgewebe mittels Weichgewebsäquivalenten sind vielfältig und lassen sich im Wesentlichen in rekonstruktive und kosmetische Indikationen unterteilen. Der Leidensdruck der Patienten ist oft sehr hoch, denn entstellende Deformationen z. B. des Gesichts, der Extremitäten oder der Brust der Frau stigmatisieren, beeinträchtigen soziale Kontakte und führen oft zur gesellschaftlichen Isolation sowie zur professionellen und finanziellen Benachteiligung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Weiterführende Literatur

  • Bach TL, Barsigian C, Chalupowicz DG, Busler D, Yaen CH, Grant DS, Martinez J (1998) VE-Cadherin Mediates Endothelial Cell Capillary Tube Formation in Fibrin and Collagen Gels. Exp cell res 238:324–334

    Article  CAS  PubMed  Google Scholar 

  • Balasz EA, Denlinger JL (1989) Clinical uses of hyaluronan. Ciba Found Symp 143:265–275

    Google Scholar 

  • Ballard KW (1978) Functional characteristics of the microcirculation in white adipose tissue. Microvasc Res 16:1–18

    Article  CAS  PubMed  Google Scholar 

  • Billings E Jr, May JW Jr (1989) Historical review and present status of free fat graft autotransplantation in plastic and reconstructive surgery. Plast Reconstr Surg 83:368–381

    Article  PubMed  Google Scholar 

  • Campoccia D, Doherty P, Radice M, Brun P, Abatangelo G, Williams DF (1998) Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials 19:2101–2127

    Article  CAS  PubMed  Google Scholar 

  • Cassell OC, Hofer SO, Morrison WA, Knight KR (2002) Vascularisation of tissue-engineered grafts: the regulation of angiogenesis in reconstructive surgery and in disease states. Br J Plast Surg 55:603–610

    Article  CAS  PubMed  Google Scholar 

  • Champaneria MC, Wong WW, Hill ME, Gupta SC (2012) The evolution of breast reconstruction: a historical perspective. World J Surg 36(4):730–742

    Article  PubMed  Google Scholar 

  • Choi YS, Park SN, Suh H (2005) Adipose tissue engineering using mesenchymal stem cells attached to injectable PLGA spheres. Biomaterials 26:5855–5863

    Article  CAS  PubMed  Google Scholar 

  • Coleman SR (2001) Structural fat grafts: the ideal filler? Clin Plast Surg 28:111–119

    CAS  PubMed  Google Scholar 

  • Crandall DL, Hausman GJ, Kral JG (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4:211–232

    Article  CAS  PubMed  Google Scholar 

  • Ellenbogen R (2000) Fat transfer: current use in practice. Clin Plast Surg 27:545–556

    CAS  PubMed  Google Scholar 

  • Eppley BL, Snyders RV, Winkelmann T, Delfino JJ (1992) Autologous facial fat transplantation: improved graft maintenance by microbead bioactivation. J Oral Maxillofac Surg 50:477–482

    Article  CAS  PubMed  Google Scholar 

  • Fischbach C, Spruss T, Weiser B, Neubauer M, Becker C, Hacker M, Göpferich A, Blunk T (2004) Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes. Exp Cell Res 300:54–64

    Article  CAS  PubMed  Google Scholar 

  • Fischer-Posovszky P, Wabitsch M (2004) Entwicklung und Funktion des Fettgewebes. Monatsschrift Kinderheilkd 142:834–842

    Article  Google Scholar 

  • Flynn L, Prestwich GD, Semple JL, Woodhouse KA (2007) Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells. Biomaterials 28:3834–42

    Article  CAS  PubMed  Google Scholar 

  • Goodstein WA (1996) Superficial liposculpture of the face and neck. Plast Reconstr Surg 98:988–996 (discussion 997–988)

    Article  CAS  PubMed  Google Scholar 

  • Green H, Kehinde O (1975) An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5(1):19–27

    Article  CAS  PubMed  Google Scholar 

  • Gregoire FM, Smas CM, Sul HS (1998) Understanding adipocyte differentiation. Physiol Rev 78:783–809

    CAS  PubMed  Google Scholar 

  • Gunatillake P, Adhikari R (2003) Biodegradable synthetic polymers for tissue engineering. ECM 5:1–16

    CAS  PubMed  Google Scholar 

  • Halberstadt C, Austin C, Rowley J, Culberson C, Loebsack A, Wyatt S, Coleman S, Blacksten L, Burg K, Mooney D, Holder W (2002) A hydrogel material for plastic and reconstructive applications injected into the subcuta-neous space of a sheep. Tissue Eng 8:309–319

    Article  CAS  PubMed  Google Scholar 

  • Hausberger FX (1955) Quantitative studies on the development of autotransplants of immature adipose tissue of rats. Anat Rec 122(4):507–515

    Article  CAS  PubMed  Google Scholar 

  • von Heimburg D, Hemmrich K, Haydarlioglu S, Staiger H, Pallua N (2004) Comparison of viable cell yield from excised versus aspirated adipose tissue. Cells Tissues Organs 178:87–92

    Article  Google Scholar 

  • von Heimburg D, Hemmrich K, Zachariah S, Staiger H, Pallua N (2005) Oxygen consumption in undifferentiated versus differentiated adipogenic mesenchymal precursor cells. Respir Physiol Neurobiol 146:107–116

    Article  Google Scholar 

  • Hemmrich K, Van de Sijpe K, Rhodes NP, Hunt JA, Di Bartolo C, Pallua N, Blondeel P, von Heimburg D (2008) Autologous in vivo adipose tissue engineering in hyaluronan-based gels – a pilot study. J Surg Res 144:82–88

    Article  CAS  PubMed  Google Scholar 

  • Hemmrich K, von Heimburg D (2006) Biomaterials for adipose tissue engineering. Expert Rev Med Devices 3:635–45

    Article  CAS  PubMed  Google Scholar 

  • Hemmrich K, von Heimburg D, Rendchen R, Di Bartolo C, Milella E, Pallua N (2005) Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering. Biomaterials 26:7025–7037

    Article  CAS  PubMed  Google Scholar 

  • Huss FR, Kratz G (2002) Adipose tissue processed for lipoinjection shows increased cellular survival in vitro when tissue engineering principles are applied. Scand J Plast Reconstr Hand Surg 36:166–171

    Article  Google Scholar 

  • Keck M, Haluza D, Selig HF, Jahl M, Lumenta DB, Kamolz LP, Frey M (2011) Adipose tissue engineering: three different approaches to seed preadipocytes on a collagen-elastin matrix. Ann Plast Surg 67:484–8

    Article  CAS  PubMed  Google Scholar 

  • Katz AJ, Llull R, Hedrick MH, Futrell JW (1999) Emerging approaches to the tissue engineering of fat. Clin Plast Surg 26:587–603

    CAS  PubMed  Google Scholar 

  • Kawaguchi N, Toriyama K, Nicodemou-Lena E, Inou K, Torii S, Kitagawa Y (1999) Reconstituted basement membrane potentiates in vivo adipogenesis of 3T3-F442A cells. Cytotechnology 31:215–220

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kimura Y, Ozeki M, Inamoto T, Tabata Y (2003) Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor. Biomaterials 24:2513–2521

    Article  CAS  PubMed  Google Scholar 

  • Korff T, Augustin HG (1998) Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol 143:1341–1352

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kral JG, Crandall DL (1999) Development of a human adipocyte synthetic polymer scaffold. Plast Reconstr Surg 104:1732–1738

    Article  CAS  PubMed  Google Scholar 

  • Loeb L (1897) Ueber die Entstehung von Bindegewebe, Leukozyten und roten Blutkörperchen aus Epithel und ueber eine Methode, isolierte Gewebsteile zu züchten. Stern, Chicago

    Google Scholar 

  • Maloney BP, Murphy BA, Cole HP (2004) Cymetra. Facial Plast Surg 20:129–134

    Article  PubMed  Google Scholar 

  • Masuda T, Furue M, Matsuda T (2004) Photocured, styrenated gelatin-based microspheres for de novo adipogenesis through corelease of basic fibroblast growth factor, insulin, and insulin-like growth factor I. Tissue Eng 10:523–535

    Article  CAS  PubMed  Google Scholar 

  • McDonough J, Lilien J (1977) The turnover of a tissue specific cell surface ligand which inhibits lectin induced capping. J Supramol Struct 7:409–418

    Article  CAS  PubMed  Google Scholar 

  • Nehls V, Drenckhahn D (1995) A microcarrier-based cocultivation system for the investigation of factors and cells involved in angiogenesis in three-dimensional fibrin matrices in vitro. Histochem Cell Biol 104(6):459–466

    Article  CAS  PubMed  Google Scholar 

  • Patrick CW, Chauvin PB, Hobley J, Reece GP (1999) Preadipocyte seeded PLGA scaffolds for adipose tissue engineering. Tissue Eng 5:139–151

    Article  CAS  PubMed  Google Scholar 

  • Patrick CW (2004) Breast tissue engineering. Annu Rev Biomed Eng 6:109–130

    Article  CAS  PubMed  Google Scholar 

  • Patrick CW Jr (2000) Adipose tissue engineering: the future of breast and soft tissue reconstruction following tumor resection. Semin Surg Oncol 19:302–311

    Article  PubMed  Google Scholar 

  • Patrick CW Jr (2001) Tissue engineering strategies for adipose tissue repair. Anat Rec 263:361–366

    Article  CAS  PubMed  Google Scholar 

  • Pepper MS, Montesano R, Vassalli JD, Orci L (1991) Chondrocytes inhibit endothelial sprout formation in vitro: evidence for involvement of a transforming growth factor-beta. J Cell Physiol 146:170–179

    Article  CAS  PubMed  Google Scholar 

  • Planat-Benard V, Silvestre JS, Cousin B, Andre M, Nibbelink M, Tamarat R, Clergue M, Manneville C, Saillan-Barreau C, Duriez M, Tedgui A, Levy B, Penicaud L, Casteilla L (2004) Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation 109:656–663

    Article  PubMed  Google Scholar 

  • Ramirez OM (2001) Full face rejuvenation in three dimensions: a “face-lifting” for the new millennium. Aesthetic Plast Surg 25:152–164

    Article  CAS  PubMed  Google Scholar 

  • Rosen ED, Spiegelman BM (2000) Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16:145–171

    Article  CAS  PubMed  Google Scholar 

  • Schultheiss D, Bloom DA, Wefer J, Jonas U (2000) Tissue engineering from Adam to the zygote: historical reflections. World J Urol 18:84–90

    Article  CAS  PubMed  Google Scholar 

  • Silver FH, Pins G (1992) Cell growth on collagen: a review of tissue engineering using scaffolds containing extracellular matrix. J Long Term Eff Med Implants 2:67–80

    CAS  PubMed  Google Scholar 

  • Stacey DH, Hanson SE, Lahvis G, Gutowski KA, Masters KS (2009) In vitro adipogenic differentiation of preadipocytes varies with differentiation stimulus, culture dimensionality, and scaffold composition. Tissue Eng Part A 15:3389–3399

    Article  CAS  PubMed  Google Scholar 

  • Smahel J (1986) Adipose tissue in plastic surgery. Ann Plast Surg 16:444–453 (Smahel J (1986) Adipose tissue in plastic surgery. Ann Plast Surg 16: 444–453)

    Article  CAS  PubMed  Google Scholar 

  • Tabata Y, Miyao M, Inamoto T, Ishii T, Hirano Y, Yamaoki Y, Ikada Y (2000) De novo formation of adipose tissue by controlled release of basic fibroblast growth factor. Tissue Eng 6:279–289

    Article  CAS  PubMed  Google Scholar 

  • Tegtmeier F (2004) Tissue Engineering von Fettgewebe durch Kultivierung humaner Präadipozyten und Endothelzellen. Doctoral Dissertation, Universitätsbibliothek Freiburg

    Google Scholar 

  • Toledo LS, Mauad R (2006) Fat injection: a 20-year revision. Clin Plast Surg 33:47–53

    Article  PubMed  Google Scholar 

  • Van RL, Roncari DA (1977) Isolation of fat cell precursors from adult rat adipose tissue. Cell Tissue Res 181:197–203

    Article  CAS  PubMed  Google Scholar 

  • Vats A, Tolley NS, Polak JM, Gough JE (2003) Scaffolds and biomaterials for tissue engineering: a review of clinical applications. Clin Otolaryngol Allied Sci 28:165–172

    Article  CAS  PubMed  Google Scholar 

  • Virchow R (1858) Die Cellularpathologie in ihrer Begründung auf physiologische und pathophysiologische Gewebelehre. Hirschwald, Berlin

    Google Scholar 

  • Wechselberger G, Russell RC, Neumeister MW, Schoeller T, Piza-Katzer H, Rainer C (2002) Successful transplantation of three tissue-engineered cell types using capsule induction technique and fibrin glue as a delivery vehicle. Plast Reconstr Surg 110:123–129

    Article  PubMed  Google Scholar 

  • Wertheimer E, Shapiro B (1948) The physiology of adipose tissue. Physiol Rev 28:451–464

    CAS  PubMed  Google Scholar 

  • Wosnitza M, Hemmrich K, Groger A, Graber S, Pallua N (2007) Plasticity of human adipose stem cells to perform adipogenic and endothelial differentiation. Differentiation 75:12–23

    Article  CAS  PubMed  Google Scholar 

  • Zangani D, Darcy KM, Masso-Welch PA, Bellamy ES, Desole MS (1999) Multiple differentiation pathways of rat mammary stromal cells in vitro: acquisition of a fibroblast, adipocyte or endothelial phenotype is dependent on hormonal and extracellular matrix stimulation. Differentiation 64:91–101

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Plast. Chirurgie Hand- und Verbrennungschirurgie, Universitätsklinikum - RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    Univ.-Prof. Dr. Dr., Prof. h.c. mult. Norbert Pallua

  2. Klinik für Unfall- und Handchirurgie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    Prof. Dr. rer. nat. Christoph Suschek

  3. Klinik für Plast. Chirurgie, Hand- und Verbrennungschirurgie, Universitätsklinikum der RWTH, Pauwelsstr. 30, 52074, Aachen, Deutschland

    Dipl. Biol. Christine M. Volkmar

Authors
  1. Univ.-Prof. Dr. Dr., Prof. h.c. mult. Norbert Pallua
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. rer. nat. Christoph Suschek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dipl. Biol. Christine M. Volkmar
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hannover, Germany

    Alfred Berger

  2. Plastische Chirurgie, Wiederherstellungs- und Handchirurg Plastische Chirurgie, Moers, Nordrhein-Westfalen, Germany

    Robert Hierner

  3. Klinik für Plastische Chirurgie, Ha, Universitätsklinikum - RWTH Aachen, Aachen, Nordrhein-Westfalen, Germany

    Norbert Pallua

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Pallua, N., Suschek, C., Volkmar, C.M. (2017). Adulte Stammzellen des Fettgewebes in der regenerativen Medizin. In: Berger, A., Hierner, R., Pallua, N. (eds) Plastische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48849-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-48849-2_1

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-48848-5

  • Online ISBN: 978-3-662-48849-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation