Skip to main content
SpringerLink
Log in

Langzeitfolgen nach Krebs im Kindes- und Jugendalter – Die Nachsorge der von einer Krebserkrankung geheilten Kinder und Jugendlichen

  • Living reference work entry
  • First Online:
Kompendium Internistische Onkologie

Part of the book series: Springer Reference Medizin ((SRM))

  • 227 Accesses

Zusammenfassung

Dank verbesserter Therapiemöglichkeiten haben sich die Langzeitüberlebensraten der Patienten mit einer Krebserkrankung im Kindes- und Jugendalter in den letzten Jahrzehnten deutlich verbessert. Durch die zur Heilung der Krebserkrankung eingesetzten Therapien können jedoch auch viele Jahre nach Therapieende noch Folgeerkrankungen, sogenannte Spätfolgen, auftreten, die zu einer hohen Morbidität und verminderten gesundheitsbezogenen Lebensqualität der Langzeitkrebsüberlebenden führen. Das Auftreten vieler Spätfolgen erfolgt mit einer langen Latenz zum Behandlungsende und wird durch die erhaltene Behandlung und durch individuelle Risikofaktoren der Patienten bestimmt. Dabei können die Spätfolgen unterschiedliche Organe betreffen und von leichten Störungen bis zu lebensbedrohlichen Komplikationen oder Erkrankungen, wie beispielsweise einer neuen Krebserkrankung, reichen. Viele Patienten sind zum Zeitpunkt des Auftretens der Spätfolgen allerdings bereits erwachsen und befinden sich nicht mehr in regelmäßiger pädiatrisch-onkologischer Betreuung. Da das meiste Wissen über Spätfolgen aus den letzten 20 Jahren stammt, sind zudem viele der zuvor erkrankten Patienten nie über ihr Risiko für potenzielle therapieassoziierte Folgeerkrankungen aufgeklärt worden. Dies ist die Aufgabe für die betreuenden Ärzte während der Langzeitnachsorgebetreuung, um mögliche Spätfolgen frühzeitig entdecken und behandeln zu können.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Armenian SH, Ding Y, Mills G, Sun C, Venkataraman K, Wong FL, Neuhausen SL, Senitzer D, Wang S, Forman SJ, Bhatia S (2013) Genetic susceptibility to anthracycline-related congestive heart failure in survivors of haematopoietic cell transplantation. Br J Haematol 163(2):205–213

    CAS  PubMed  PubMed Central  Google Scholar 

  • Armenian SH, Hudson MM, Mulder RL, Chen MH, Constine LS, Dwyer M, Nathan PC, Tissing WJ, Shankar S, Sieswerda E, Skinner R, Steinberger J, van Dalen EC, van der Pal H, Wallace WH, Levitt G Kremer LC; International Late Effects of Childhood Cancer Guideline Harmonization Group. (2015) Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol 16(3):e123–e136

    Google Scholar 

  • Armstrong GT, Liu W, Leisenring W, Yasui Y, Hammond S, Bhatia S, Neglia JP, Stovall M, Srivastava D, Robison LL (2011) Occurrence of multiple subsequent neoplasms in long-term survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 29(22):3056–3064

    Article  PubMed  PubMed Central  Google Scholar 

  • Armstrong GT, Plana JC, Zhang N, Srivastava D, Green DM, Ness KK, Daniel Donovan F, Metzger ML, Arevalo A, Durand JB, Joshi V, Hudson MM, Robison LL, Flamm SD (2012) Screening adult survivors of childhood cancer for cardiomyopathy: comparison of echocardiography and cardiac magnetic resonance imaging. J Clin Oncol 30(23):2876–2884

    Article  PubMed  PubMed Central  Google Scholar 

  • Barakat LP, Alderfer MA, Kazak AE (2006) Posttraumatic growth in adolescent survivors of cancer and their mothers and fathers. J Pediatr Psychol 31:413–419

    Article  PubMed  Google Scholar 

  • Beck JD, Winkler K, Niethammer D, Brandis M, Hertzberg H, von der Hardt K, Greil J, Uberall MA, Rossi R, Lamprecht-Dinnesen A, et al. (1995) After-care of children and young adults surviving cancer. Initial recommendations by the late sequelae study group. Klin Padiatr 207:186–192

    Article  CAS  PubMed  Google Scholar 

  • Brinkman TM, Zhu L, Zeltzer LK, Recklitis CJ, Kimberg C, Zhang N, Muriel AC, Stovall M, Srivastava DK, Robison LL, Krull KR (2013) Longitudinal patterns of psychological distress in adult survivors of childhood cancer. Br J Cancer 109(5):1373–1381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calaminus G, Weinspach S, Teske C, Göbel U (2007) Quality of survival in children and adolescents after treatment for childhood cancer: the influence of reported late effects on health related quality of life. Klin Padiatr 219(3):152–157

    Article  CAS  PubMed  Google Scholar 

  • Calaminus G, Dorffel W, Baust K, Teske C, Riepenhausen M, Bramswig J et al (2014) Quality of life in long-term survivors following treatment for Hodgkin‘s disease during childhood and adolescence in the German multicentre studies between 1978 and 2002. Support Care Cancer 22(6):1519–1529. https://doi.org/10.1007/s00520-013-2114-y

    Article  PubMed  Google Scholar 

  • Cheung YT, Sabin ND, Reddick WE, Bhojwani D, Liu W, Brinkman TM, Glass JO, Hwang SN, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR (2016) Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis. Lancet Haematol 3(10):e456–e466

    Article  PubMed  PubMed Central  Google Scholar 

  • Dieluweit U, Debatin K-M, Grabow D, Kaatsch P, Peter R, Seitz DCM, Goldbeck L (2011) Educational and vocational achievement among long-term survivors of adolescent cancer in Germany. Pediatr Blood Cancer 56(3):432–438. https://doi.org/10.1002/pbc.22806

    Article  PubMed  Google Scholar 

  • Dörffel W, Riepenhausenl M, Lüders H, Brämswig J, Schellong G (2015) Secondary malignancies following treatment for Hodgkin‘s lymphoma in childhood and adolescence. Dtsch Arztebl Int 112(18):320–327

    PubMed  PubMed Central  Google Scholar 

  • Dŏrr HG, Koch A, Kühl J, Müller HL, Beck JD (1996) Endocrinologic after-care of brain tumor patients: initial retrospective analysis of HIT-study documented auxologic and endocrine parameters. Klin Padiatr 208(4):197–204

    PubMed  Google Scholar 

  • Franco VI, Lipshultz SE (2015) Cardiac complications in childhood cancer survivors treated with anthracyclines. Cardiol Young 25(Suppl 2):107–116

    Article  PubMed  Google Scholar 

  • Gesellschaft für Pädiatrische Onkologie und Hämatologie (2013) AWMF Leitlinie „Nachsorge von krebskranken Kindern, Jugendlichen und jungen Erwachsenen – Erkennen, Vermeiden und Behandeln von Spätfolgen“. http://www.awmf.org/leitlinien/detail/ll/025-003.html. Zugegriffen am 09.03.2021

  • Gesellschaft für Pädiatrische Onkologie und Hämatologie, Deutsche Gesellschaft für Kinderendokrinologie und -diabetologie (2014) Endokrinologische Nachsorge nach onkologischen Erkrankungen im Kindes- und Jugendalter. https://www.awmf.org/leitlinien/detail/ll/025-030.html. Zugegriffen am 09.03.2021

  • Gunst DC, Kaatsch P, Goldbeck L (2016) Seeing the good in the bad: which factors are associated with posttraumatic growth in long-term survivors of adolescent cancer? Support Care Cancer 24(11):4607–4615

    Article  PubMed  Google Scholar 

  • Jacola LM, Edelstein K, Liu W, Pui CH, Hayashi R, Kadan-Lottick NS, Srivastava D, Henderson T, Leisenring W, Robison LL, Armstrong GT, Krull KR (2016) Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the childhood cancer survivor study. Lancet Psychiatry 3(10):965–972

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaatsch P, Reinisch I, Spix C, Berthold F, Janka-Schaub G, Mergenthaler A, Michaelis J, Blettner M (2009) Case-control study on the therapy of childhood cancer and the occurrence of second malignant neoplasms in Germany. Cancer Causes Control 20(6):965–980

    Article  PubMed  Google Scholar 

  • Klein G, Michaelis J, Spix C, Wibbing R, Eggers G, Ritter J, Kaatsch P (2003) Second malignant neoplasms after treatment of childhood cancer. Eur J Cancer 39(6):808–817

    Article  CAS  PubMed  Google Scholar 

  • Krappmann P, Paulides M, Stöhr W, Ittner E, Plattig B, Nickel P, Lackner H, Schrappe M, Janka G, Beck JD, Langer T (2007) Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up. Pediatr Hematol Oncol 24(2):101–109

    Article  CAS  PubMed  Google Scholar 

  • Kuehni CE, Strippoli M-PF, Rueegg CS, Rebholz CE, Bergstraesser E, Grotzer M et al (2012) Educational achievement in Swiss childhood cancer survivors compared with the general population. Cancer 118(5):1439–1449. https://doi.org/10.1002/cncr.26418

    Article  PubMed  Google Scholar 

  • Landy DC, Miller TL, Lipsitz SR, Lopez-Mitnik G, Hinkle AS, Constine LS, Adams MJ, Lipshultz SE (2013) Cranial irradiation as an additional risk factor for anthracycline cardiotoxicity in childhood cancer survivors: an analysis from the cardiac risk factors in childhood cancer survivors study. Pediatr Cardiol 34(4):826–834

    Article  PubMed  Google Scholar 

  • Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O (2013) Understanding platinum-induced ototoxicity. Trends Pharmacol Sci 34(8):458–469

    Article  CAS  PubMed  Google Scholar 

  • Langer T, Martus P, Ottensmeier H, Hertzberg H, Beck JD, Meier W (2002) CNS late-effects after ALL therapy in childhood. Part III: neuropsychological performance in long-term survivors of childhood ALL: impairments of concentration, attention, and memory. Med Pediatr Oncol 38(5):320–328

    Article  PubMed  Google Scholar 

  • Lanvers-Kaminsky C, Sprowl JA, Malath I, Deuster D, Eveslage M, Schlatter E, Mathijssen RH, Boos J, Jürgens H, Am Zehnhoff-Dinnesen AG, Sparreboom A, Ciarimboli G (2015) Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity. Pharmacogenomics 16(4):323–332

    Article  CAS  PubMed  Google Scholar 

  • Lipshultz SE, Cochran TR, Franco VI, Miller TL (2013) Treatment-related cardiotoxicity in survivors of childhood cancer. Nat Rev Clin Oncol 10(12):697–710

    Article  CAS  PubMed  Google Scholar 

  • Lipshultz SE, Miller TL, Lipsitz SR, Neuberg DS, Dahlberg SE, Colan SD, Silverman LB, Henkel JM, Franco VI, Cushman LL, Asselin BL, Clavell LA, Athale U, Michon B, Laverdière C, Schorin MA, Larsen E, Usmani N, Sallan SE, Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium (2012) Continuous versus bolus infusion of doxorubicin in children with ALL: long-term cardiac outcomes. Pediatrics 130(6):1003–1011

    Article  PubMed  PubMed Central  Google Scholar 

  • Lipshultz SE, Scully RE, Lipsitz SR, Sallan SE, Silverman LB, Miller TL, Barry EV, Asselin BL, Athale U, Clavell LA, Larsen E, Moghrabi A, Samson Y, Michon B, Schorin MA, Cohen HJ, Neuberg DS, Orav EJ, Colan SD (2010) Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol 11(10):950–961

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Löning L, Zimmermann M, Reiter A, Kaatsch P, Henze G, Riehm H, Schrappe M (2000) Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy. Blood 95(9):2770–2775

    Article  PubMed  Google Scholar 

  • Marx M, Langer T, Beck JD, Dörr HG (1999) Disorders of endocrine function after brain tumor therapy in childhood. Strahlenther Onkol 175(7):305–308

    Article  CAS  PubMed  Google Scholar 

  • Maunsell E, Pogany L, Barrera M, Shaw AK, Speechley KN (2006) Quality of life among long-term adolescent and adult survivors of childhood cancer. J Clin Oncol 24(16):2527–2535. https://doi.org/10.1200/JCO.2005.03.9297

    Article  PubMed  Google Scholar 

  • Nottage K, McFarlane J, Krasin MJ, Li C, Srivastava D, Robison LL, Hudson MM (2012) Secondary colorectal carcinoma after childhood cancer. J Clin Oncol 30(20):2552–2558

    Article  PubMed  Google Scholar 

  • Nysom K, Holm K, Hertz H, Hesse B (1998) Risk factors for reduced pulmonary function after malignant lymphoma in childhood. Med Pediatr Oncol 30(4):240–248

    Article  CAS  PubMed  Google Scholar 

  • Oancea SC, Gurney JG, Ness KK, Ojha RP, Tyc VL, Klosky JL, Srivastava D, Stokes DC, Robison LL, Hudson MM, Green DM (2014) Cigarette smoking and pulmonary function in adult survivors of childhood cancer exposed to pulmonary-toxic therapy: results from the St. Jude lifetime cohort study. Cancer Epidemiol Biomark Prev 23(9):1938–1943

    Article  CAS  Google Scholar 

  • oncopedia (2016) Heranwachsende und junge Erwachsene (AYA, Adolescents and Young Adults). https://www.onkopedia.com/de/onkopedia/guidelines/heranwachsende-und-junge-erwachsene-aya-adolescents-and-young-adults/@@guideline/html/index.html. Zugegriffen am 09.03.2021

  • Ranke MB, Dopfer R, Blum WF, Niethammer D (1991) Approaches to the evaluation of growth and growth disorders in children after bone marrow transplantation (BMT). Bone Marrow Transplant 8(Suppl 1):6–9

    PubMed  Google Scholar 

  • Robison LL, Hudson MM (2014) Survivors of childhood and adolescent cancer: life-long risks and responsibilities. Nat Rev Cancer 4:61–70

    Article  CAS  Google Scholar 

  • Seitz DC, Besier T, Debatin KM, Grabow D, Dieluweit U, Hinz A, Kaatsch P, Goldbeck L (2010) Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence. Eur J Cancer 46(9):1596–1606. https://doi.org/10.1016/j.ejca.2010.03.001. Epub 2010 Apr 8

    Article  PubMed  Google Scholar 

  • Shalet SM, Clayton PE, Price DA (1988) Growth and pituitary function in children treated for brain tumours or acute lymphoblastic leukaemia. Horm Res 30(2-3):53–61

    Article  CAS  PubMed  Google Scholar 

  • Sherborne A, Lavergne V, Yu K, Lee L, Davidson P, Mazor T, Smirnov IV, Horvai AE, Loh M, Dubois SG, Goldsby R, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura A, Shannon KM, Bhatia S, Nakamura JL (2016) Somatic and germline TP53 alterations in second malignant neoplasms from pediatric cancer survivors. Clin Cancer Res 2017(23):1852–1861

    Google Scholar 

  • Skinner R, Parry A, Price L, Cole M, Craft AW, Pearson AD (2009) Persistent nephrotoxicity during 10-year follow-up after cisplatin or carboplatin treatment in childhood: relevance of age and dose as risk factors. Eur J Cancer 45(18):3213–3219

    Article  CAS  PubMed  Google Scholar 

  • Skinner R, Pearson AD, English MW, Price L, Wyllie RA, Coulthard MG, Craft AW (1996) Risk factors for ifosfamide nephrotoxicity in children. Lancet 348(9027):578–580

    Article  CAS  PubMed  Google Scholar 

  • Sprangers MA, Schwartz CE (1999) Integrating response shift into health-related quality of life research: a theoretical model. Soc Sci Med 48:1507–1515

    Article  CAS  PubMed  Google Scholar 

  • Stöhr W, Langer T, Kremers A, Brecht I, Treuner J, Dinnesen A, Beck JD (2004) Hearing function in soft tissue sarcoma patients after treatment with carboplatin: a report from the late effects surveillance system. Oncol Rep 12(4):767–771

    PubMed  Google Scholar 

  • Tedeschi RG, Calhoun LG (2004) Posttraumatic growth: conceptual foundations and empirical evidence. Psychol Inq 15:1–18

    Article  Google Scholar 

  • Trachtenberg BH, Landy DC, Franco VI, Henkel JM, Pearson EJ, Miller TL, Lipshultz SE (2011) Anthracycline-associated cardiotoxicity in survivors of childhood cancer. Pediatr Cardiol 32(3):342–353

    Article  PubMed  Google Scholar 

  • Turcotte LM, Whitton JA, Friedman DL, Hammond S, Armstrong GT, Leisenring W, Robison LL, Neglia JP (2015) Risk of subsequent neoplasms during the fifth and sixth decades of life in the childhood cancer survivor study cohort. J Clin Oncol 33(31):3568–3575

    Article  PubMed  PubMed Central  Google Scholar 

  • Versluys AB, Bresters D (2016) Pulmonary complications of childhood cancer treatment. Paediatr Respir Rev 17:63–70

    PubMed  Google Scholar 

  • Visscher H, Ross CJ, Rassekh SR, Barhdadi A, Dubé MP, Al-Saloos H, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Brown AM, Rogers PC, Phillips MS, Rieder MJ, Carleton BC, Hayden MR, Canadian Pharmacogenomics Network for Drug Safety Consortium (2012) Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children. J Clin Oncol 30(13):1422–1428

    Article  PubMed  Google Scholar 

  • Von Hoff DD, Layard MW, Basa P, Davis HL Jr, Von Hoff AL, Rozencweig M, Muggia FM. (1979) Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 91:710–717

    Article  Google Scholar 

  • Wang X, Sun CL, Quiñones-Lombraña A, Singh P, Landier W, Hageman L, Mather M, Rotter JI, Taylor KD, Chen YD, Armenian SH, Winick N, Ginsberg JP, Neglia JP, Oeffinger KC, Castellino SM, Dreyer ZE, Hudson MM, Robison LL, Blanco JG, Bhatia S (2016) CELF4 variant and anthracycline-related cardiomyopathy: a children‘s oncology group genome-wide association study. J Clin Oncol 34(8):863–870

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zebrack BJ, Chesler MA (2002) Quality of life in childhood cancer survivors. Psycho-Oncology 11(2):132–141

    Article  PubMed  Google Scholar 

  • Zeltzer LK, Lu Q, Leisenring W, Tsao JC, Recklitis C, Armstrong G, Mertens AC, Robison LL, Ness KK (2008) Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the childhood cancer survivorstudy. Cancer Epidemiol Biomark Prev 17(2):435–446. (11):4607–4615

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie und Onkologie, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland

    Thorsten Langer

  2. Zentrum für Kinder- und Jugendmedizin, Abt. für Päd. Hämatologie/Onkologie, Universitätsklinikum Bonn, Bonn, Deutschland

    Katja Baust & Gabriele Calaminus

  3. Pädiatrie 5 (Onkologie, Hämatologie und Immunologie), Klinikum Stuttgart – Olgahospital, Stuttgart, Deutschland

    Stefan Bielack

Authors
  1. Thorsten Langer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katja Baust
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stefan Bielack
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriele Calaminus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thorsten Langer .

Editor information

Editors and Affiliations

  1. Abt. Hämatologie und Onkologie, Universitätsklinikum Halle-Wittenberg Klinik und Poliklinik Innere Medizin IV, Halle, Sachsen-Anhalt, Germany

    Hans-Joachim Schmoll

Section Editor information

  1. Pädiatrische Hämatologie/ Onkologie, Medizinische Hochschule Hannover, Hannover, Germany

    Ursula Creutzig

  2. Klinik für Pädiatrische Onkologie und Hämatologie, Universität des Saarlandes, Universitätsklinikum, Homburg/Saar, Deutschland

    Norbert Graf

  3. Klinische Studien in der Onkologie, Universitätsklinikum Halle (Saale), Halle, Deutschland

    Hans-Joachim Schmoll

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Langer, T., Baust, K., Bielack, S., Calaminus, G. (2021). Langzeitfolgen nach Krebs im Kindes- und Jugendalter – Die Nachsorge der von einer Krebserkrankung geheilten Kinder und Jugendlichen. In: Schmoll, HJ. (eds) Kompendium Internistische Onkologie . Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46764-0_289-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-46764-0_289-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-46764-0

  • Online ISBN: 978-3-662-46764-0

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Search

Navigation