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The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling

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Interleukin-10 in Health and Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 380))

Abstract

Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.

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Acknowledgments

This review is supported in part by the National Institutes of Health Grants AI047300, AI0473-S1, AI049342, and AI097629.

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  1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Mark R. Walter

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  1. Mark R. Walter
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Correspondence to Mark R. Walter .

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  1. Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany

    Simon Fillatreau

  2. Div. of Immunoregulation, The MRC National Institute for Medical Research, London, United Kingdom

    Anne O'Garra

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Walter, M.R. (2014). The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling. In: Fillatreau, S., O'Garra, A. (eds) Interleukin-10 in Health and Disease. Current Topics in Microbiology and Immunology, vol 380. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43492-5_9

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