Skip to main content
SpringerLink
Log in

Mesothelioma

  • Chapter
  • First Online:
Pathology of Asbestos-Associated Diseases

Abstract

Mesothelioma, literally “tumor of the mesothelium,” is a term often used synonymously with malignant (diffuse) mesothelioma, the malignant neoplasm arising from the serosal linings of the pleural, pericardial, or peritoneal cavities. These major body cavities are lined by a single layer of flattened to cuboidal cells of mesodermal origin that constitute the mesothelium proper [1]. This serosal membranous lining includes not only the mesothelium but also the underlying basement membrane, a matrix of elastic fibroconnective tissue containing lymphatic and vascular channels, and scattered mesenchymal cells as well. Mesothelial cells possess a complex cytoskeletal network of intermediate filaments, produce hyaluronic acid, and have distinctive ultrastructural features including numerous pinocytotic vesicles and long surface microvilli that project into the serous cavities (Fig. 5.1) [2, 3]. It remains uncertain whether mesothelioma results from the malignant transformation of the differentiated mesothelial cell or from more primitive progenitor cells, such as the submesothelial mesenchymal cell, or from both [4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Stedman’s medical dictionary, 22nd edn. (1972) Williams & Wilkins, Baltimore

    Google Scholar 

  2. Roggli VL, Kolbeck J, Sanfilippo F, Shelburne JD (1987) Pathology of human mesothelioma: etiologic and diagnostic considerations. Pathol Annu 22(Part 2):91–131

    PubMed  Google Scholar 

  3. Kuhn C (1976) The cells of the lung and their organelles. In: Crystal RG (ed) The biochemical basis of pulmonary function. Marcel Dekker, New York, pp 3–48

    Google Scholar 

  4. Davis JMG (1979) The histopathology and ultrastructure of pleural mesotheliomas produced in the rat by injections of crocidolite asbestos. Br J Exp Pathol 60:642–652

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Roggli VL, Oury TD, Moffatt EJ (1997) Malignant mesothelioma in women. Anat Pathol 2:147–163

    CAS  PubMed  Google Scholar 

  6. Browne K (1994) Asbestos-related disorders. In: Parkes WR (ed) Occupational lung disorders, 3rd edn. Butterworths, London, pp 411–504

    Google Scholar 

  7. McDonald JC (1985) Health implications of environmental exposure to asbestos. Environ Health Perspect 62:319–328

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Spirtas R, Beebe GW, Connelly RR et al (1986) Recent trends in mesothelioma incidence in the United States. Am J Ind Med 9:397–407

    Article  CAS  PubMed  Google Scholar 

  9. McDonald AD, McDonald JC (1987) Epidemiology of malignant mesothelioma, Ch 2. In: Antman K, Aisner J (eds) Asbestos-related malignancy. Harcourt Brace Jovanovich, Orlando, pp 31–55

    Google Scholar 

  10. National Cancer Institute (2011) SEER cancer statistics review 1975-2008. National Cancer Institute, Bethesda

    Google Scholar 

  11. Churg A, Roggli V, Galateau-Sallé F et al (2004) Mesothelioma. In: Travis WD, Brambilla E, Müller-Hermelink HK, Harris C (eds) Pathology and genetics of tumours of the lung, pleura, thymus and heart. IARC, Lyon, pp 128–136

    Google Scholar 

  12. Leigh J, Davidson P, Hendrie L, Berry D (2001) Malignant mesothelioma in Australia, 1945-2000. Am J Ind Med 41:188–201

    Article  Google Scholar 

  13. Churg A, Cagle PT, Roggli VL (2006) Tumors of the serosal membranes. In: Atlas of tumor pathology, 4th Series, Fascicle3. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  14. Aisner J, Wiernick PH (1978) Malignant mesothelioma: current status and future prospects. Chest 74:438–443

    CAS  PubMed  Google Scholar 

  15. Chahinian AP (1982) Malignant mesothelioma. In: Holland JF, Frei E III (eds) Cancer medicine. Lea & Febiger, Philadelphia, pp 1744–1751

    Google Scholar 

  16. Wagner E (1870) Das tuberkelahnliche lymphadenom. Arch d Heilkunde 11:497–526

    Google Scholar 

  17. Hammar SP, Henderson DW, Klebe S, Dodson RF (2008) Neoplasms of the pleura, Ch 43. In: Tomashefski JF, Cagle PT, Farver CF, Fraire A (eds) Pulmonary pathology, 3rd edn. Springer, New York, pp 558–734

    Google Scholar 

  18. Craighead JE (1988) Eyes for the epidemiologist: the pathologist’s role in shaping our understanding of the asbestos-associated diseases. Am J Clin Pathol 89:281–287

    Article  CAS  PubMed  Google Scholar 

  19. Robertson HE (1924) “Endothelioma” of the pleura. J Cancer Res 8:317–375

    Google Scholar 

  20. Klemperer P, Rabin CB (1931) Primary neoplasms of the pleura: report of five cases. Arch Pathol 11:385–412

    Google Scholar 

  21. McCaughey WTE, Kannerstein M, Churg J (1985) Tumors and pseudotumors of the serosal membranes. In: Atlas of tumor pathology, 2nd Series, Fascicle 20. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  22. Castleman BI (1984) Asbestos: medical and legal aspects. Harcourt Brace Jovanovich, New York

    Google Scholar 

  23. Gloyne SR (1933) The morbid anatomy and histology of asbestosis. Tubercle 14:550–558

    Article  CAS  Google Scholar 

  24. Wedler HW (1943) Uber den Lungenkrebs bei Asbestose. Dtsch Arch Klin Med 191:189–209

    Google Scholar 

  25. Mallory TB, Castleman B, Parris EE (1947) Case records of the Massachusetts General Hospital # 33111. N Engl J Med 236:407–412

    Article  Google Scholar 

  26. Lee DHK, Selikoff IJ (1979) Historical background to the asbestos problem. Environ Res 18:300–314

    Article  CAS  PubMed  Google Scholar 

  27. Keal EE (1960) Asbestosis and abdominal neoplasms. Lancet 2:1211–1216

    Article  CAS  PubMed  Google Scholar 

  28. Wagner JC, Sleggs CA, Marchand P (1960) Diffuse pleural mesothelioma and asbestos exposure in Northwestern Cape Province. Br J Ind Med 17:260–271

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Edge JR, Choudhoury SL (1978) Malignant mesothelioma of the pleura in Barrow-in-Furness. Thorax 33:26–30

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. McDonald AD, McDonald JC (1980) Malignant mesothelioma in North America. Cancer 46:1650–1656

    Article  CAS  PubMed  Google Scholar 

  31. Otto H (1980) Das berufsbedingte Mesotheliom in der BRD. Pathologe 2:8–18

    CAS  PubMed  Google Scholar 

  32. Churg A (1985) Malignant mesothelioma in British Columbia in 1982. Cancer 5:672–674

    Article  Google Scholar 

  33. Andersson M, Olsen JH (1985) Trend and distribution of mesothelioma in Denmark. Br J Cancer 51:699–705

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Malker HSR, McLaughlin JK, Malker BK et al (1985) Occupational risks for pleural mesotheliomas in Sweden, 1961-79. J Natl Cancer Inst 74:61–66

    CAS  PubMed  Google Scholar 

  35. Connelly RR, Spirtas R, Myers MH, Percy CL, Fraumeni JF (1987) Demographic patterns for mesothelioma in the United States. J Natl Cancer Inst 78:1053–1060

    CAS  PubMed  Google Scholar 

  36. Ferguson DA, Berry G, Jelihovsky T et al (1987) The Australian mesothelioma surveillance program 1979-1985. Med J Australia 147:166–172

    CAS  PubMed  Google Scholar 

  37. Elmes PC, McCaughey WTE, Wade OL (1965) Diffuse mesothelioma of the pleura and asbestos. Br Med J 1:350–353

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Newhouse ML, Thompson H (1965) Mesothelioma of the pleura and peritoneum following exposure to asbestos in London area. Br J Ind Med 22:261–269

    CAS  PubMed  PubMed Central  Google Scholar 

  39. McEwen I, Finlayson A, Mair A et al (1970) Mesothelioma in Scotland. Br Med J 4:575–578

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. McDonald AD, Harper A, El Attar OA et al (1970) Epidemiology of primary malignant mesothelial tumors in Canada. Cancer 26:914–919

    Article  CAS  PubMed  Google Scholar 

  41. Rubino GF, Scansetti G, Donna A et al (1972) Epidemiology of pleural mesothelioma in northwestern Italy (Piedmont). Br J Ind Med 29:436

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Ashcroft T (1973) Epidemiologic and quantitative relationships between mesothelioma and asbestos on Tyneside. J Clin Pathol 26:832–840

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Hain E, Dalquen P, Bohlig H et al (1974) Retrospective study of 150 cases of mesothelioma in the Hamburg area. Int Arch Arbeitsmed 33:15–37

    Article  CAS  PubMed  Google Scholar 

  44. Zielhuis RL, Versteeg JPJ, Planteydt HT (1975) Pleural mesothelioma and exposure to asbestos: a retrospective case control study in the Netherlands. Int Arch Occup Environ Health 36:1–18

    Article  CAS  PubMed  Google Scholar 

  45. Britton M (2002) The epidemiology of mesothelioma. Semin Oncol 29:18–25

    Article  PubMed  Google Scholar 

  46. Sheers G, Coles RM (1980) Mesothelioma risks in a naval dockyard. Arch Environ Health 35:276–282

    Article  CAS  PubMed  Google Scholar 

  47. Selikoff IJ, Hammond EC, Seidman H (1979) Mortality experience of insulation workers in the United States and Canada, 1943-1976. In: Selikoff IJ, Hammond EC (eds) Health hazards of asbestos exposure. Ann N Y Acad Sci 330:91–116

    Google Scholar 

  48. Ribak J, Lilis R, Suzuki Y, Penner L, Selikoff IJ (1988) Malignant mesothelioma in a cohort of asbestos insulation workers: clinical presentation, diagnosis, and causes of death. Br J Ind Med 45:182–187

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Churg A (1986) Analysis of asbestos fibers from lung tissue: research and diagnostic uses. Sem Respir Med 7:281–288

    Article  Google Scholar 

  50. Schenker MB, Garshick E, Munoz A, Woskie SR, Speizer FE (1986) A population-based case-control study of mesothelioma deaths among U.S. railroad workers. Am Rev Respir Dis 134:461–465

    CAS  PubMed  Google Scholar 

  51. Mancuso TF (1988) Relative risk of mesothelioma among railroad machinists exposed to chrysotile. Am J Ind Med 13:639–657

    Article  CAS  PubMed  Google Scholar 

  52. Wolf KM, Piotrowski ZH, Engel JD et al (1987) Malignant mesotheliomas with occupational and environmental asbestos exposure in an Illinois community hospital. Arch Intern Med 147:2145–2149

    Article  CAS  PubMed  Google Scholar 

  53. Roggli VL, Sharma A, Butnor KJ, Sporn T, Vollmer RT (2002) Malignant mesothelioma and occupational exposure to asbestos: a clinicopathologic correlation of 1445 cases. Ultrastruct Pathol 26:1–11

    Article  Google Scholar 

  54. Antman KH (1980) Malignant mesothelioma. N Engl J Med 303:200–202

    Article  CAS  PubMed  Google Scholar 

  55. Craighead JE, Mossman BT (1982) Pathogenesis of asbestos-associated diseases. N Engl J Med 306:1446–1455

    Article  CAS  PubMed  Google Scholar 

  56. Ferrante D, Bertolotti M, Todesco A, Mirabelli D, Terrancini B, Magnani C (2007) Cancer mortality and incidence of mesothelioma in a cohort of wives of asbestos workers in casale monferrato, Italy. Environ Health Perspect 115:1401–1405

    PubMed  PubMed Central  Google Scholar 

  57. Peretz A, VanHee VC, Kramer MR, Pitlik S, Keifer MC (2008) Pleural plaques related to “take-home” exposure to asbestos: an international case series. Int J Gen Med 1:15–20

    PubMed  Google Scholar 

  58. Rake C, Gilham C, Hatch J, Darnton A, Hodgson J, Peto J (2009) Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study. Br J Cancer 100:1175–1183

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Bourdès V, Boffetta P, Pisani P (2000) Environmental exposure to asbestos and risk of pleural mesothelioma: review and meta-analysis. Eur J Epidemiol 165:411–417

    Article  Google Scholar 

  60. Magnani C, Agudo A, González CA et al (2000) Multicentric study on malignant pleural mesothelioma and non-occupational exposure to asbestos. Br J Cancer 83:104–111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Maule MM, Magnani C, Dalmasso P et al (2007) Modeling mesothelioma risk associated with environmental asbestos exposure. Environ Health Perspect 115:1066–1071

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Musti M, Pollice A, Carvone D et al (2009) The relationship between malignant mesothelioma and an asbestos cement plant environmental risk: a spatial case-control study in the city of Bari (Italy). Int Arch Occup Environ Health 82:489–497

    Article  CAS  PubMed  Google Scholar 

  63. Barbieri PG, Marabelli D, Somigliana A, Cavone D, Merler E (2012) Asbestos fibre burden in the lungs of patients with mesothelioma who lived near asbestos-cement factories. Ann Occup Hyg 56(6):660–670

    CAS  PubMed  Google Scholar 

  64. Kurumatani N, Kumagai S (2008) Mapping the risk of mesothelioma due to neighborhood asbestos exposure. Am J Respir Crit Care Med 178:624–629

    Article  PubMed  Google Scholar 

  65. Reid A, Berry G, De Klerk N, Hansen J, Heyworth J, Ambrosini G, Fritschi L, Olsen N, Merler E, Musk AW (2007) Age and sex differences after residential exposure to blue asbestos (Crocidolite). Chest 131:376–382

    Article  PubMed  Google Scholar 

  66. Whitehouse AC, Black CB, Heppe MS, Ruckdeschel J, Levin SM (2008) Environmental exposure to Libby asbestos and mesotheliomas. Am J Ind Med 51:877–880

    Article  PubMed  Google Scholar 

  67. Reid A, Heyworth J, Musk A (2008) The mortality of women exposed environmentally and domestically to blue asbestos at Wittenoom, Western Australia. Occup Environ Med 65:743–749

    Article  CAS  PubMed  Google Scholar 

  68. Case BW, Abraham JL (2009) Heterogeneity of exposure and attribution of mesothelioma trends and strategies in two American counties. J Phys Conf Ser 151:15

    Article  CAS  Google Scholar 

  69. Pan X, Day HW, Want W, Beckett LA, Schenker MB (2005) Residential proximity to naturally occurring asbestos and mesothelioma risk in California. Am J Respir Crit Care Med 172:1019–1025

    Article  PubMed  PubMed Central  Google Scholar 

  70. Talcott J, Thurber W, Gaensler E, Antman K, Li FP (1987) Mesothelioma in manufacturers of asbestos-containing cigarette filters. Lancet 1:392

    Google Scholar 

  71. Driscoll RJ, Mulligan WJ, Schultz D, Candelaria A (1988) Malignant mesothelioma: a cluster in a native American pueblo. N Engl J Med 318:1437–1438

    Article  CAS  PubMed  Google Scholar 

  72. Li FP, Dreyfus MG, Antman K (1989) Asbestos-contaminated nappies and familial mesothelioma. Lancet 1:909–910

    Google Scholar 

  73. Marchevsky AM, Harber P, Crawford L, Wick M (2006) Mesothelioma in patients with nonoccupational asbestos exposure. An evidence-based approach to causation assessment. Ann Diagn Pathol 10:241–250

    Article  PubMed  Google Scholar 

  74. Spirtas R, Heinemann EF, Bernstein L, Beebe GW, Keehn RJ et al (1994) Malignant mesothelioma: attributable risk of asbestos exposure. Occup Environ Med 51:804–811

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. National Research Council (1984) Non-occupational risks of asbestiform fibers. National Academy Press, Washington, DC

    Google Scholar 

  76. McDonald AD, McDonald JC (1978) Mesothelioma after crocidolite exposure during gas mask manufacture. Environ Res 17:340–347

    Article  CAS  PubMed  Google Scholar 

  77. Selikoff IJ, Hammond EC, Seidman H (1980) Latency of asbestos disease among insulation workers in the United States and Canada. Cancer 46:2736–2740

    Article  CAS  PubMed  Google Scholar 

  78. Churg A (1998) Neoplastic asbestos-induced disease, Ch 10. In: Churg A, Green FHY (eds) Pathology of occupational lung disease, 2nd edn. Williams & Wilkins, Baltimore, pp 339–392

    Google Scholar 

  79. Peto J, Seidman H, Selikoff IJ (1982) Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. Br J Cancer 45:124–135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Chronic Hazard Advisory Panel on Asbestos (1983) Report to the U.S. consumer product safety commission. Directorate for Health Sciences, Washington, DC

    Google Scholar 

  81. Browne K, Smither WJ (1983) Asbestos-related mesothelioma: factors discriminating between pleural and peritoneal sites. Br J Ind Med 40:145–152

    CAS  PubMed  PubMed Central  Google Scholar 

  82. Jarvholm B, Sanden A (1998) Lung cancer and mesothelioma in the pleura and peritoneum among Swedish insulation workers. Occup Environ Med 55:766–770

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Roggli VL (1995) Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral content. Ann Occup Hyg 39:363–374

    Article  CAS  PubMed  Google Scholar 

  84. Delgermaa V, Takahashi K, Park EK, Le GV, Hara T, Sorahan T (2011) Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008. Bull World Health Organ 89:716–724

    Article  PubMed  PubMed Central  Google Scholar 

  85. Larson T, Melnikova N (2007) Incidence and descriptive epidemiology of mesothelioma in the United States, 1999-2002. Int J Occup Environ Health 13:398–403

    Article  PubMed  Google Scholar 

  86. Roggli VL, Pratt PC, Brody AR (1993) Asbestos fiber types in malignant mesothelioma: an analytical scanning electron microscopic study. Am J Ind Med 23:605–614

    Article  CAS  PubMed  Google Scholar 

  87. Dunnigan J (1988) Linking chrysotile asbestos with mesothelioma. Am J Ind Med 14:205–209

    Article  CAS  PubMed  Google Scholar 

  88. Churg A (1988) On Dr. Dunnigan’s commentary linking chrysotile asbestos with mesothelioma. Am J Ind Med 14:235–238

    Article  CAS  PubMed  Google Scholar 

  89. Becklake MR (1988) On Dr Dunnigan’s commentary linking chrysotile asbestos with mesothelioma. Am J Ind Med 14:239–240

    Article  CAS  PubMed  Google Scholar 

  90. Craighead JE (1988) Response to Dr Dunnigan’s commentary. Am J Ind Med 14:241–243

    Article  CAS  PubMed  Google Scholar 

  91. Roggli VL, Pratt PC (1988) Amphiboles and chrysotile asbestos exposure. Am J Ind Med 14:245–246

    Article  CAS  PubMed  Google Scholar 

  92. McDonald JC (1988) Tremolite, other amphiboles, and mesothelioma. Am J Ind Med 14:247–249

    Article  CAS  PubMed  Google Scholar 

  93. Schneider F, Sporn TA, Roggli VL (2008) Crocidolite and mesothelioma. Ultrastruct Pathol 32:171–177

    Article  PubMed  Google Scholar 

  94. Churg A, Wright JL, Vedal S (1993) Fiber burden and patterns of disease in long term chrysotile miners and millers. Am Rev Respir Dis 148:25–31

    Article  CAS  PubMed  Google Scholar 

  95. Churg A, DiPaoli L, Kempe B, Stevens B (1984) Lung asbestos content in chrysotile workers with mesothelioma. Am Rev Respir Dis 130:1042–1045

    CAS  PubMed  Google Scholar 

  96. Dufresne A, Begin R, Churg A, Masse S (1996) Mineral fibre content of lungs in mesothelioma cases seeking compensation in Quebec. Am J Respir Crit Care Med 153:711–718

    Article  CAS  PubMed  Google Scholar 

  97. Churg A (1988) Chrysotile, tremolite and mesothelioma in man. Chest 93:621–628

    Article  CAS  PubMed  Google Scholar 

  98. Wagner JC, Berry G, Pooley FD (1982) Mesotheliomas and asbestos type in asbestos textile workers: a study of lung contents. Br Med J 285:603–606

    Article  CAS  Google Scholar 

  99. Green FHY, Harley R, Vallyathan V et al (1997) Exposure and mineralogical correlates of pulmonary fibrosis in chrysotile asbestos textile workers. Occup Environ Med 54:549–559

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Loomis D, Dement JM (2009) Lung cancer mortality and fibre exposures among NC asbestos textile workers. Occup Environ Med 66:535–542

    Article  CAS  PubMed  Google Scholar 

  101. McDonald AD, McDonald JC, Pooley FD (1982) Mineral fiber content of lung in mesothelial tumors in North America. Ann Occup Hyg 26:417–422

    CAS  PubMed  Google Scholar 

  102. McDonald JC (2010) Epidemiology of malignant mesothelioma – an outline. Ann Occup Hyg 54:851–857

    PubMed  Google Scholar 

  103. Karjalainen A, Meurman LO, Pukkala E (1994) Four cases of mesothelioma among Finnish anthophyllite miners. Occup Environ Med 51:212–215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Yarborough CM (2006) Chrysotile as a cause of mesothelioma: an assessment based on epidemiology. Crit Rev Toxicol 36:165–187

    Article  CAS  PubMed  Google Scholar 

  105. White N, Nelson G, Murry J (2008) South African experience with asbestos related environmental mesothelioma: is asbestos fiber type important? Regul Toxicol Pharmacol 52(suppl 1):S92–S96

    Article  CAS  PubMed  Google Scholar 

  106. Wagner JC, Berry G, Skidmore JW, Timbrell V (1974) The effect of the inhalation of asbestos in rats. Br J Cancer 29:252–269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Elmes P (1994) Mesotheliomas and chrysotile. Ann Occup Hyg 38:547–553

    CAS  PubMed  Google Scholar 

  108. Price B, Ware A (2008) Time trend of mesothelioma incidence in the United States and projection of future cases: an update based on SEER data for 1973-2005. Crit Rev Toxicol 39:576–588

    Article  Google Scholar 

  109. Pierce JS, McKinley MA, Paustenbach DJ, Finley BL (2008) An evaluation of reported no-effect chrysotile asbestos exposure for lung cancer and mesothelioma. Crit Rev Toxicol 38:191–214

    Article  CAS  PubMed  Google Scholar 

  110. Carbone M, Kratzke RA, Testa JR (2002) The pathogenesis of mesothelioma. Semin Oncol 29:2–17

    Article  CAS  PubMed  Google Scholar 

  111. Roggli VL, Vollmer RT (2008) Twenty-five years of fiber analysis: what have we learned? Hum Pathol 39:307–315

    Article  CAS  PubMed  Google Scholar 

  112. Baris YL, Artvinli M, Sahin AA (1979) Environmental mesothelioma in Turkey. Ann N Y Acad Sci 330:423–432

    Article  CAS  PubMed  Google Scholar 

  113. Coplu L, Dumortier P, Demir AU et al (1982) An epidemiological study in an Anatolian village in Turkey environmentally exposed to tremolite asbestos. J Environ Pathol Toxicol Oncol 15:177–182

    Google Scholar 

  114. Zeren EH, Gumurdulu D, Roggli VL, Zorludemir S, Erkisi M, Tuncer I (2000) Environmental malignant mesothelioma in Southern Anatolia: a study of 50 cases. Environ Health Perspect 108:1047–1050

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Pooley FD (1979) Evaluation of fiber samples taken from the vicinity of two villages in Turkey. In: Lemen R, Dement JM (eds) Dusts and disease: occupational and environmental exposures to selected fibrous and particulate dusts. Pathotox Publishing, Park Forest South, pp 41–44

    Google Scholar 

  116. Sebastien P, Gaudichet A, Bignon J, Baris YI (1981) Zeolite bodies in human lungs from Turkey. Lab Invest 44:420–425

    CAS  PubMed  Google Scholar 

  117. Rohl AN, Langer AM, Moncure G, Selikoff IJ, Fischbein A (1982) Endemic pleural disease associated with exposure to mixed fibrous dust in Turkey. Science 216:518–520

    Article  CAS  PubMed  Google Scholar 

  118. Maltoni C, Minardi F, Morisi L (1982) Pleural mesotheliomas in Sprague Dawley rats by erionite: first experimental evidence. Environ Res 29:238–244

    Article  CAS  PubMed  Google Scholar 

  119. Suzuki Y, Kohyama N (1984) Malignant mesothelioma induced by asbestos in the mouse peritoneal cavity. Environ Res 35:277–292

    Article  CAS  PubMed  Google Scholar 

  120. Fraire AE, Greenberg SD, Spjut HJ, Dodson RF, Williams G, Lach-Pasko E, Roggli VL (1997) Effect of erionite upon the pleural mesothelium of the Fischer 344 rat. Chest 111:1375–1380

    Article  CAS  PubMed  Google Scholar 

  121. Roushdy-Hammady I, Siegel J, Emri S et al (2001) Genetic susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey. Lancet 357:444–445

    Article  CAS  PubMed  Google Scholar 

  122. Dogan AU, Baris YI, Dogan M et al (2006) Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey. Cancer Res 66:5063–5068

    Article  CAS  PubMed  Google Scholar 

  123. Carbone M, Yang H (2012) Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma. Clin Cancer Res 18:598–604

    Article  CAS  PubMed  Google Scholar 

  124. Kliment CR, Clemens K, Oury TD (2009) North American erionite-associated mesothelioma with pleural plaques and pulmonary fibrosis: a case report. Int J Clin Exp Pathol 2:407–410

    PubMed  Google Scholar 

  125. Larson TC, Antao VC (2010) Bove amphibole. J Occup Environ Med 52:555–560

    Article  PubMed  Google Scholar 

  126. McDonald JC, Harris J, Armstrong B (2004) Mortality in a cohort of vermiculite miners exposed to fibrous amphibole in Libby, Montana. J Occup Environ Med 61:363–366

    Article  CAS  Google Scholar 

  127. Peterson JT, Greenberg SD, Buffler PA (1984) Non-asbestos related mesothelioma: a review. Cancer 54:367–369

    Article  Google Scholar 

  128. Gilks B, Hegedus C, Freeman H et al (1988) Malignant mesothelioma after remote abdominal radiation. Cancer 61:2019–2021

    Article  CAS  PubMed  Google Scholar 

  129. Kramer G, Gans S, Rijnders A, Leer JW (2007) Long term survival of a patient with malignant pleural mesothelioma as a late complication of radiotherapy for Hodgkin’s disease treated with 90yttrium-silicate. Lung Cancer 27:205–208

    Article  Google Scholar 

  130. Maurer R, Egloff B (1975) Malignant peritoneal mesothelioma after cholangiography with thorotrast. Cancer 36:1381–1385

    Article  CAS  PubMed  Google Scholar 

  131. Goodman JE, Nascarella MA, Vlaverg PA (2009) Ionizing radiation: a risk factor for mesothelioma. Cancer Causes Control 20:1237–1254

    Article  PubMed  Google Scholar 

  132. Antman KH, Ruxer RL, Aisner J, Vawter G (1984) Mesothelioma following Wilms’ tumor in childhood. Cancer 54:367–369

    Article  CAS  PubMed  Google Scholar 

  133. Anderson KA, Hurley WC, Hurley BT, Ohrt DW (1985) Malignant pleural mesothelioma following radiotherapy in a 16-year old boy. Cancer 56:273–276

    Article  CAS  PubMed  Google Scholar 

  134. Austin MB, Fechner RE, Roggli VL (1986) Pleural malignant mesothelioma following Wilms’ tumor. Am J Clin Pathol 86:227–230

    Article  CAS  PubMed  Google Scholar 

  135. De Bruin ML, Burgers JA, Bass P et al (2009) Malignant mesothelioma after radiation treatment for Hodgkin lymphoma. Blood 113:3679–3681

    Article  PubMed  CAS  Google Scholar 

  136. Henley JD, Loehrer PJ, Ulbright TM (2001) Deciduoid mesothelioma of the pleura after radiation therapy for Hodgkin disease presenting as a mediastinal mass. Am J Surg Pathol 25:547–548

    Article  CAS  PubMed  Google Scholar 

  137. Neugut AI, Ahsan H, Antman K (1997) Incidence of malignant pleural mesothelioma after thoracic radiation therapy. Cancer 80:948–950

    Article  CAS  PubMed  Google Scholar 

  138. Teta MJ, Lau E, Sceurman BK, Wagner ME (2007) Therapeutic radiation for lymphoma. Risk of malignant mesothelioma. Cancer 109:1432–1438

    Article  PubMed  Google Scholar 

  139. Tward JD, Wenland MM, Shrieve DC, Sazabo A, Gaffney DK (2006) The risk of secondary malignancies over 30 years after the treatment of non-Hodgkin lymphoma. Cancer 107:108–115

    Article  PubMed  Google Scholar 

  140. Travis LB, Fossa SD, Shonfeld SJ et al (2005) Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 97:1354–1365

    Article  PubMed  Google Scholar 

  141. Witherby SM, Butnor KJ, Grunberg SM (2007) Malignant mesothelioma following thoracic radiotherapy for lung cancer. Lung Cancer 57:410–413

    Article  PubMed  Google Scholar 

  142. Sanders CI, Jackson TA (1972) Induction of mesotheliomas and sarcomas from hotspots of 239 PuO2 activity. Health Phys 22:755–759

    Article  CAS  PubMed  Google Scholar 

  143. Melato M, Rizzardi C (2001) Malignant pleural mesothelioma after chemotherapy for breast cancer. Anticancer Res 21:3093–3096

    CAS  PubMed  Google Scholar 

  144. Carbone M, Pass HI, Rizzo P et al (1994) Simian virus 40-like DNA sequences in human pleural mesothelioma. Oncogene 9:1781–1790

    CAS  PubMed  Google Scholar 

  145. Testa JR, Carbone M, Hirvonen A et al (1998) A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas. Cancer Res 58:4505–4509

    CAS  PubMed  Google Scholar 

  146. Jasani B, Cristaudo A, Emri SA et al (2001) Association of SV40 with human tumors. Semin Cancer Biol 11:43–61

    Article  CAS  Google Scholar 

  147. Cicala C, Pompetti F, Carbone M (1993) SV40 induces mesotheliomas in hamsters. Am J Pathol 42:1524–1533

    Google Scholar 

  148. Carbone M, Fisher S, Powers A et al (1999) New molecular and epidemiologic issues in mesothelioma: role of SV 40. J Cell Physiol 180:167–172

    Article  CAS  PubMed  Google Scholar 

  149. Kops SP (2000) Oral polio vaccine and human cancer: a reassessment of SV40 as a contaminant based upon legal documents. Anticancer Res 20:4745–4750

    CAS  PubMed  Google Scholar 

  150. Rizzo P, Di Resta I, Powers A et al (1999) Unique strains of SV40 in commercial polio vaccines from 1955 not readily identifiable with current testing for SV40 infection. Cancer Res 59:6103–6108

    CAS  PubMed  Google Scholar 

  151. Mossman BT, Gruenert DC (2002) SV40, growth factors and mesothelioma – another piece of the puzzle. Am J Respir Cell Mol Biol 26:167–170

    Article  CAS  PubMed  Google Scholar 

  152. Carbone M, Rizzo P, Grimley A et al (1997) Simian virus 40 large-T antigen binds p53 in human mesotheliomas. Nat Med 3:908–912

    Article  CAS  PubMed  Google Scholar 

  153. DeLuca A, Baldi V, Esposito CM et al (1997) The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus 40 large T-antigen in human mesotheliomas. Nat Med 3:913–916

    Article  CAS  Google Scholar 

  154. Bocchetta M, Di Resta A, Powers R et al (2000) Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity. Proc Natl Acad Sci U S A 97:10214–10219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  155. Klein G, Powers A, Croce C (2002) Association of SV40 with human tumors. Oncogene 21:1141–1149

    Article  CAS  PubMed  Google Scholar 

  156. Pass H, Donington P, Wu P, Rizzo M et al (1998) Human mesotheliomas contain the simian virus 40 regulatory region and large tumor antigen DNA sequences. J Thorac Cardiovasc Surg 116:854–859

    Article  CAS  PubMed  Google Scholar 

  157. Caccioti P, Strizzi L, Vianale G et al (2002) The presence of simian virus 40 sequences in mesothelioma and mesothelial cells is associated with high levels of vascular endothelial growth factor. Am J Respir Cell Mol Biol 26:189–193

    Article  Google Scholar 

  158. Shivapurkar N, Wiethege I, Wistuba E et al (1999) Presence of simian virus 40 sequences in malignant mesotheliomas and mesothelial cell proliferations. J Cell Biochem 76:181–188

    Article  CAS  PubMed  Google Scholar 

  159. Strickler HD, Goedert JJ, Devesa SS, Lajey J, Fraumenti JF, Rosenberg PS (2003) Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines. J Natl Cancer Inst 95:38–45

    Article  CAS  PubMed  Google Scholar 

  160. Engles EA, Katki HA, Nielsen NM, Winther JF, Hjalgrim H, Gjerris F et al (2003) Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40. J Natl Cancer Inst 95:532–539

    Article  Google Scholar 

  161. Manfredi JJ, Dong J, Liu WJ, Resnick-Silverman L, Qiao R, Chahinian P et al (2005) Evidence against a role for SV40 in human mesothelioma. Cancer Res 65:2602–2609

    Article  CAS  PubMed  Google Scholar 

  162. Lundstig A, Deimek A, Eklund C, Fillinic I, Dillner J (2007) No detection of SV40 DNA in mesothelioma tissues from a high incidence area in Sweden. Anticancer Res 27:4159–4161

    CAS  PubMed  Google Scholar 

  163. Toyoka S, Pass H, Shivapurkar Y et al (2001) Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma. Cancer Res 61:5727–5730

    Google Scholar 

  164. Hirvonen A, Mattson K, Karjalainen A et al (1999) SV40-like DNA sequences not detectable in Finnish mesothelioma patients not exposed to SV40 contaminated polio vaccines. Mol Carcinog 26:93–99

    Article  CAS  PubMed  Google Scholar 

  165. Hubner R, Van ME (2002) Reappraisal of the strong association between simian virus 40 and human malignant mesothelioma of the pleura (Belgium). Cancer Causes Control 13:121–129

    Article  PubMed  Google Scholar 

  166. Pilatte Y, Vivo C, Renier A et al (2000) Absence of SV40 large T-antigen expression in human mesothelioma cell lines. Am J Respir Cell Mol Biol 23:788–793

    Article  CAS  PubMed  Google Scholar 

  167. Nelson NJ (2001) Debate on the link between SV40 and human cancer continues. J Natl Cancer Inst 93:1284–1286

    Article  CAS  PubMed  Google Scholar 

  168. Strickler HD, Goedert JJ, Bueno R et al (2001) A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens. Cancer Epidemiol Biomarkers Prev 10:523–532

    CAS  PubMed  Google Scholar 

  169. Strickler HD, Rosenberg PS, Devesa SS, Hertel J, Fraumeni JF, Goedert JJ (1998) Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates. JAMA 279:292–295

    Article  CAS  PubMed  Google Scholar 

  170. Bianchi C, Brollo A, Ramani L, Bianchi T, Giafelli L (2004) Familial mesothelioma of the pleura. A report of 40 cases. Ind Health 42:235–239

    Article  PubMed  Google Scholar 

  171. Risberg B, Nickels J, Wagermark J (1980) Familial clustering of malignant mesothelioma. Cancer 45:2422–2427

    Article  CAS  PubMed  Google Scholar 

  172. Lynch HT, Katz D, Marvicka SE (1985) Familial mesothelioma: review and family study. Cancer Genet Cytogenet 15:25–35

    Article  CAS  PubMed  Google Scholar 

  173. Hammar SP, Bockus D, Remington F, Freidman S, Lazerte G (1989) Familial mesothelioma: a report of two families. Hum Pathol 20:107–112

    Article  CAS  PubMed  Google Scholar 

  174. Dawson A, Gibbs AR, Browne K, Pooley FD, Griffiths DM (1992) Familial mesotheliomas: details of 17 cases with histopathologic findings and mineral analysis. Cancer 70:1183–1187

    Article  CAS  PubMed  Google Scholar 

  175. Ascoli V, Cavone D, Merier E, Barbieri PG, Romeo L, Nardi F, Musti M (2007) Mesothelioma in blood related subjects: report of 11 clusters among 1954 Italy cases and review of the literature. Am J Ind Med 50:357–369

    Article  PubMed  Google Scholar 

  176. Attanoos RL, Gibbs AR (1997) Pathology of malignant mesothelioma. Histopathology 30:403–418

    Article  CAS  PubMed  Google Scholar 

  177. Otte KE, Sigstaard TI, Kjaerulff J (1990) Malignant mesothelioma: clustering in the family producing asbestos cement in their home. Br J Ind Med 47:10–13

    CAS  PubMed  PubMed Central  Google Scholar 

  178. Testa RJ, Cheung M, Pei J et al (2011) Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet 43:1022–1025

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  179. Bott M et al (2011) The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet 43:668–672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  180. Hillerdal G, Berg J (1985) Malignant mesothelioma secondary to chronic inflammation and old scars: 2 cases and a review of the literature. Cancer 55:1968–1972

    Article  CAS  PubMed  Google Scholar 

  181. Riddell RH, Goodman MJ, Moosa AR (1981) Peritoneal malignant mesothelioma in a patient with recurrent peritonitis. Cancer 48:134–139

    Article  CAS  PubMed  Google Scholar 

  182. Roggli VL, McGavran MH, Subach JA, Sybers HD, Greenberg SD (1982) Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma: a study of 25 cases. Cancer 50:2423–2432

    Article  CAS  PubMed  Google Scholar 

  183. Sorahan T (2007) Mortality of UK oil refinery and petroleum distribution workers, 1951-2003. Occup Med 57:177–185

    Article  Google Scholar 

  184. Gennaro V, Finkelstein MM, Ceppi M, Fontana V, Montanaro F, Perrotta A, Puntoni R, Silvano S (2000) Mesothelioma and lung tumors attributable to asbestos among petroleum workers. Am J Ind Med 37:275–282

    Article  CAS  PubMed  Google Scholar 

  185. Gold C (1967) A primary mesothelioma involving the rectovaginal septum and associated with beryllium. J Pathol Bacteriol 93:435–442

    Article  CAS  PubMed  Google Scholar 

  186. Newman RH (1986) Fine biogenic particulate silica fibres in sugarcane: a possible hazard. Ann Occup Hyg 30:365–370

    CAS  PubMed  Google Scholar 

  187. Fraire AE, Cooper S, Greenberg SD, Buffler P, Langston C (1988) Mesothelioma of childhood. Cancer 62:838–847

    Article  CAS  PubMed  Google Scholar 

  188. Nishioka H, Furusho K, Yasunaga T et al (1988) Congenital mesothelioma: case report and electron microscopic study. Eur J Pediatr 147:428–430

    Article  CAS  PubMed  Google Scholar 

  189. Hillerdal G (1983) Malignant msothelioma1982: review of 4710 published cases. Br J Dis Chest 77:321–343

    Article  CAS  PubMed  Google Scholar 

  190. Corson JM (1997) Pathology of diffuse malignant pleural mesothelioma. Semin Thorac Cardiovasc Surg 9:347–355

    CAS  PubMed  Google Scholar 

  191. Boutin C, Rey F, Gouvernet J (1993) Thoracoscopy in pleural mesotheliomas: a prospective study of 188 patients. Part 2. Prognosis and staging. Cancer 72:393–404

    Google Scholar 

  192. McCaughey WTE (1965) Criteria for the diagnosis of diffuse mesothelial tumors. Ann N Y Acad Sci 132:603–613

    Article  CAS  PubMed  Google Scholar 

  193. Craighead JE, Abraham JL, Churg A et al (1982) Pathology of asbestos-associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading schema (report of the Pneumoconiosis Committee of the College of American Pathologists and the National Institute for Occupational Safety and Health). Arch Pathol Lab Med 106:544–596

    CAS  PubMed  Google Scholar 

  194. Sahn SA (1988) State of the art: the pleura. Am Rev Respir Dis 138:184–234

    Article  CAS  PubMed  Google Scholar 

  195. Adams VI, Unni KK, Muhm JR, Jett JR, Ilstrup DM, Bernatz PE (1986) Diffuse malignant mesothelioma of the pleura: diagnosis and survival in 92 cases. Cancer 58:1540–1551

    Article  CAS  PubMed  Google Scholar 

  196. Obers VJ, Leiman G, Girdwood RW, Spiro FI (1988) Primary malignant pleural tumors (mesotheliomas) presenting as localized masses: fine needle aspiration cytologic findings, clinical and radiologic features and a review of the literature. Acta Cytol 32:567–575

    CAS  PubMed  Google Scholar 

  197. Crotty TB, Myers JL, Katzenstein A-LA et al (1994) Localized malignant mesothelioma: a clinicopathologic and flow cytometric study. Am J Surg Pathol 18:357–363

    Article  CAS  PubMed  Google Scholar 

  198. Solomons K, Polakow R, Marchand P (1985) Diffuse malignant mesothelioma presenting as bilateral malignant lymphangitis. Thorax 40:682–683

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  199. Roberts G (1976) Distant visceral metastases in pleural mesothelioma. Br J Dis Chest 70:246–250

    Article  CAS  PubMed  Google Scholar 

  200. Elmes P, Simpson MJC (1976) The clinical aspects of mesothelioma. Q J Med 179:427–429

    Google Scholar 

  201. Marom EH, Erasmus JJ, Pass HI, Patz EF (2002) The role of imaging in malignant pleural mesothelioma. Semin Oncol 29:26–35

    Article  PubMed  Google Scholar 

  202. Alexander E, Clark RA, Colley DP, Mitchell SE (1981) CT of malignant pleural mesothelioma. Am J Roentgenol 137:287–291

    Article  CAS  Google Scholar 

  203. Mirvis S, Dutcher JP, Haney PJ, Whitley NO, Aisner J (1983) CT of malignant pleural mesothelioma. Am J Roentgenol 140:665–670

    Article  CAS  Google Scholar 

  204. Lorigan JG, Libshitz HI (1989) MR imaging of malignant pleural mesothelioma. J Comput Assist Tomogr 13:617–620

    Article  CAS  PubMed  Google Scholar 

  205. Entwisle J (2004) The use of magnetic resonance imaging in malignant mesothelioma. Lung Cancer 455:S69–S71

    Article  Google Scholar 

  206. Haberkorn U (2004) Positron emission tomography in the diagnosis of mesothelioma. Lung Cancer 455:573–576

    Google Scholar 

  207. Harwood TR, Gracey DR, Yokoo H (1985) Pseudomesotheliomatous carcinomas of the lung: a variant of peripheral lung cancer. Am J Clin Pathol 65:159–167

    Article  Google Scholar 

  208. Hammar SP (1994) The pathology of benign and malignant pleural diseases. Chest Surg Clin N Am 4:405–430

    CAS  PubMed  Google Scholar 

  209. Koss M, Travis W, Moran C, Hochholzer L (1992) Pseudomesotheliomatous adenocarcinoma: a reappraisal. Semin Diagn Pathol 9:117–123

    CAS  PubMed  Google Scholar 

  210. Attanoos RL, Gibbs AR (2003) Pseudomesotheliomatous carcinoma of the pleura: a 10-year analysis of cases from the Environmental Lung Disease Research Group, Cardiff. Histopathology 42:444–452

    Article  Google Scholar 

  211. Sporn TA, Butnor KJ, Roggli VL (2002) Epithelioid hemangioendothelioma of the pleura: an aggressive vascular malignancy and clinical mimic of malignant mesothelioma. Histopathology 41(Suppl 2):173–177

    Google Scholar 

  212. Zhang PJ, LiVolsi VA, Brooks JJ (2000) Malignant epithelioid vascular tumors of the pleura: report of a series and literature review. Hum Pathol 31:29–34

    Article  CAS  PubMed  Google Scholar 

  213. Lin B, Colby T, Gown AM et al (1999) Vascular tumors of the serosal membranes: a report of 14 cases. Am J Surg Pathol 20:1431–1439

    Article  Google Scholar 

  214. Attanoos RL, Suvarna SK, Rhead E et al (2000) Malignant vascular tumors of the pleura in “asbestos workers” and endothelial differentiation in mesothelioma. Thorax 55:860–863

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  215. Husain AN, Colby TV, Ordonez NG, Krausz T (2013) Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the international mesothelioma interest group. Arch Pathol Lab Med 137(5):647–667

    Article  PubMed  Google Scholar 

  216. Renshaw AA, Dean BR, Antman KH, Sugarbaker DJ, Cibas ES (1997) The role of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. Chest 111:106–109

    Article  CAS  PubMed  Google Scholar 

  217. Kannerstein M, Churg J (1977) Peritoneal mesothelioma. Hum Pathol 8:83–93

    Article  CAS  PubMed  Google Scholar 

  218. Churg J, Rosen SH, Moolten S (1965) Histological characteristics of mesothelioma associated with asbestos. Ann N Y Acad Sci 132:614–622

    Article  CAS  PubMed  Google Scholar 

  219. Mayall FG, Gibbs AR (1992) The histology and immunohistochemistry of small cell mesotheliomas. Histopathology 20:47–51

    Article  CAS  PubMed  Google Scholar 

  220. Ordóñez NG (2012) Mesothelioma with small cell features: report of eight cases. Mod Pathol 25:689–698

    Article  PubMed  CAS  Google Scholar 

  221. Nascimento GA, Keeney GL, Fletcher CDM (1994) Deciduoid peritoneal mesothelioma: an unusual phenotype affecting young females. Am J Surg Pathol 18:439–445

    Article  CAS  PubMed  Google Scholar 

  222. Puttagunta L, Vriend RA, Nguyen GK (2000) Deciduoid epithelial mesothelioma of the pleura with focal rhabdoid change. Am J Surg Pathol 24:1440–1443

    Article  CAS  PubMed  Google Scholar 

  223. Matsukuma S, Aida S, Hata Y et al (1996) Localized malignant peritoneal mesothelioma containing rhabdoid cells. Pathol Int 46:389–391

    Article  CAS  PubMed  Google Scholar 

  224. Ordóñez NG (2006) Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases. Mod Pathol 19:373–383

    Article  PubMed  Google Scholar 

  225. Ordonez NG (2000) Epithelial mesothelioma with deciduoid features: report of four cases. Am J Surg Pathol 24:816–823

    Article  CAS  PubMed  Google Scholar 

  226. Shanks JH, Harris M, Banerjee SS et al (2000) Mesotheliomas with deciduoid morphology: a morphologic spectrum and a variant not confined to young females. Am J Surg Pathol 24:285–294

    Article  CAS  PubMed  Google Scholar 

  227. Serio G, Scattone A, Pennella A, Giardina C, Musti M, Valente T, Pollice L (2002) Malignant deciduoid mesothelioma of the pleura: report of two cases with long survival. Histopathology 40:348–352

    Article  CAS  PubMed  Google Scholar 

  228. Monaghan H, Al-Nafussi A (2001) Deciduoid pleural mesothelioma. Histopathology 39:104–105

    Article  CAS  PubMed  Google Scholar 

  229. Reis-Filho JS, Pope LZB, Milanezi F, Balderrama CMSR, Serapiao MJ, Schmitt FC (2002) Primary epithelial malignant mesothelioma of the pleura with deciduoid features: cytohistologic and immunohistochemical study. Diagn Cytopathol 26:117–122

    Article  PubMed  Google Scholar 

  230. Henderson DW (2002) Pleomorphic malignant mesothelioma. Histopathology 41(Suppl 2):149–154

    Google Scholar 

  231. Kadota K, Suzuki K, Sima C, Rusch VW, Adusumilli PS, Travis WD (2011) Pleomorphic epithelioid diffuse malignant pleural mesothelioma. A clinicopathologic review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma. J Thorac Oncol 6:896–904

    Article  PubMed  Google Scholar 

  232. Daya D, McCaughey WT (1990) Well differentiated papillary mesothelioma of the peritoneum: a clinicopathologic study of 22 cases. Cancer 65:292–296

    Article  CAS  PubMed  Google Scholar 

  233. Goldblum J, Hart WR (1995) Localized and diffuse mesotheliomas of the genital tract and peritoneum in women: a clinicopathologic study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas and localized fibrous tumors. Am J Surg Pathol 19:1124–1137

    Article  CAS  PubMed  Google Scholar 

  234. Butnor KJ, Sporn TA, Hammar SP, Roggli VL (2001) Well-differentiated papillary mesothelioma. Am J Surg Pathol 25:1304–1309

    Article  CAS  PubMed  Google Scholar 

  235. Gallateau-Salle F (2002) Well differentiated papillary mesothelioma. Histopathology 41(Suppl 2):154–156

    Google Scholar 

  236. Yousem SA, Hochholzer L (1987) Malignant mesotheliomas with osseous and cartilaginous differentiation. Arch Pathol Lab Med 111:62–66

    CAS  PubMed  Google Scholar 

  237. Andrion A, Mazzucco G, Bernardi P, Mollo F (1989) Sarcomatous tumor of the chest wall with osteochondroid differentiation: evidence of mesothelial origin. Am J Surg Pathol 13:707–712

    Article  CAS  PubMed  Google Scholar 

  238. Klebe S, Mahar A, Henderson DW, Roggli VL (2008) Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review. Mod Pathol 21:1084–1094

    Article  PubMed  Google Scholar 

  239. Henderson DW, Attwood HD, Constance TJ, Shilkin KB, Steele RH (1988) Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. Ultrastruct Pathol 12:367–384

    Article  CAS  PubMed  Google Scholar 

  240. Klebe S, Brownlee NA, Mahar A, Bruchette JL, Sporn TA, Vollmer RT, Roggli VL (2010) Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases. Mod Pathol 23:470–479

    Article  PubMed  Google Scholar 

  241. Kannerstein M, Churg J (1980) Desmoplastic diffuse mesothelioma. In: Fenoglio CM, Wolff M (eds) Progress in surgical pathology. Masson Pub, New York, pp 19–29

    Google Scholar 

  242. Cantin R, Al-Jabi M, McCaughey WTE (1982) Desmoplastic diffuse mesothelioma. Am J Surg Pathol 6:215–222

    Article  CAS  PubMed  Google Scholar 

  243. Mangano WE, Cagle PT, Churg A, Vollmer RT, Roggli VL (1998) The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining. Am J Clin Pathol 110:191–199

    Article  CAS  PubMed  Google Scholar 

  244. Stout A (1965) Biological effects of asbestos. Ann N Y Acad Sci 130:680–682

    Google Scholar 

  245. Adams VI, Unni KK (1984) Diffuse malignant mesothelioma of the pleura: diagnostic criteria based on an autopsy study. Am J Clin Pathol 82:15–23

    Article  CAS  PubMed  Google Scholar 

  246. Churg A, Collby TV, Cagle PT, Corson JM, Gibbs AR, Gilks B, Grimes MM, Hammar SP, Roggli VL, Travis WD (2000) The separation of benign and malignant mesothelial proliferations. Am J Surg Pathol 24:1183–1200

    Article  CAS  PubMed  Google Scholar 

  247. Cagle P, Brown R, Lebovitz R (1994) p53 immunostaining in the differentiation of reactive processes from malignancy in pleural biopsy specimens. Hum Pathol 5:443–448

    Article  Google Scholar 

  248. Harrison RN (1984) Sarcomatous pleural mesotheliomas and cerebral metastases: case report and review of eight cases. Eur J Respir Dis 65:185–188

    CAS  PubMed  Google Scholar 

  249. Huncharek M, Muscat J (1987) Metastases in diffuse pleural mesotheliomas: influence of histologic type. Thorax 42:897–898

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  250. Huncharek M, Smith K (1988) Extrathoracic lymph node metastases in malignant pleural mesothelioma. Chest 93:443–444

    Article  CAS  PubMed  Google Scholar 

  251. Machin T, Mashiyama ET, Henderson JAM, McCaughey WTE (1988) Bony metastases in desmoplastic pleural mesothelioma. Thorax 43:155–156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  252. Waxler B, Eisenstein R, Battifora H (1979) Electrophoresis of tissue glycosaminoglycans as an aid in the diagnosis of mesotheliomas. Cancer 44:221–227

    Article  CAS  PubMed  Google Scholar 

  253. MacDougall DB, Wang SE, Zidar BL (1992) Mucin-positive epithelial mesothelioma. Arch Pathol Lab Med 116:874–880

    CAS  PubMed  Google Scholar 

  254. Cooke DS, Attanoos RL, Jalloh SS, Gibbs AR (1999) “Mucin-positive” epithelial mesotheliomas of the peritoneum: an unusual diagnostic pitfall. Histopathology 37:33–36

    Article  Google Scholar 

  255. Hammar SP, Bockus DE, Remington FL, Rohrbach KA (1996) Mucin-positive epithelial mesotheliomas: a histochemical, immunohistochemical and ultrastructural comparison with mucin-producing pulmonary adenocarcinoma. Ultrastruct Pathol 20:293–325

    Article  CAS  PubMed  Google Scholar 

  256. Wang NS, Huang SN, Gold P (1979) Absence of carcinoembryonic antigen material in mesothelioma. Cancer 44:937–943

    Article  CAS  PubMed  Google Scholar 

  257. Blobel GA, Moll R, Franke WW, Kayser KW, Gould VE (1985) The intermediate filament cytoskeleton of malignant mesotheliomas and its diagnostic significance. Am J Pathol 121:235–247

    CAS  PubMed  PubMed Central  Google Scholar 

  258. Battifora H, Kopinski MI (1985) Distinction of mesothelioma from adenocarcinoma: an immunohistochemical approach. Cancer 55:1679–1685

    Article  CAS  PubMed  Google Scholar 

  259. Gibbs AR, Harach R, Wagner JC, Jasani B (1985) Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. Thorax 40:91–95

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  260. Holden J, Churg A (1984) Immunohistochemical staining for keratin and carcinoembryonic antigen in the diagnosis of malignant mesothelioma. Am J Surg Pathol 8:277–279

    Article  CAS  PubMed  Google Scholar 

  261. Loosli H, Hurlimann J (1984) Immunohistological study of malignant diffuse mesotheliomas of the pleura. Histopathology 8:793–803

    Article  CAS  PubMed  Google Scholar 

  262. van Muijen GNP, Ruiter DJ, Ponec M, Huiskens van der Mey C, Warnaar SO (1984) Monoclonal antibodies with different specificities against cytokeratins: an immunohistochemical study of normal tissues and tumors. Am J Pathol 114:9–17

    Google Scholar 

  263. Bolen JW, Hammar SP, McNutt MA (1986) Reactive and neoplastic serosal tissue: a light-microscopic, ultrastructural, and immunocytochemical study. Am J Surg Pathol 10:34–47

    Article  CAS  PubMed  Google Scholar 

  264. Montag AG, Pinkus GS, Corson JM (1988) Keratin protein immunoreactivity of sarcomatoid and mixed types of diffuse malignant mesotheliomas: an immunoperoxidase study of 30 cases. Hum Pathol 19:336–342

    Article  CAS  PubMed  Google Scholar 

  265. Epstein JI, Budin RE (1986) Keratin and epithelial membrane antigen immunoreactivity in nonneoplastic fibrous pleural lesions: implications for the diagnosis of desmoplastic mesothelioma. Hum Pathol 17:514–519

    Article  CAS  PubMed  Google Scholar 

  266. Cagle PT, Truong L, Roggli VL, Greenberg SD (1989) Immunohistochemical differentiation of sarcomatoid mesotheliomas from other spindle cell neoplasms. Am J Clin Pathol 92:566–571

    Article  CAS  PubMed  Google Scholar 

  267. Wick MR, Loy T, Mills SE et al (1990) Malignant epithelioid pleural mesothelioma versus peripheral pulmonary adenocarcinoma: a histochemical, ultrastructural, and immunohistologic study of 103 cases. Hum Pathol 21:759–766

    Article  CAS  PubMed  Google Scholar 

  268. Ordonez NG (1998) Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol 22:1215–1221

    Article  CAS  PubMed  Google Scholar 

  269. Cury PM, Butcher DN, Fisher C et al (2000) Value of the mesothelium-associated antibodies thrombomodulin, cytokeratin 5/6, calretinin, and CD44H in distinguishing epithelioid pleural mesothelioma from adenocarcinoma metastatic to the pleura. Mod Pathol 13:107–112

    Article  CAS  PubMed  Google Scholar 

  270. Chu P, Wu E, Weiss LM (2000) Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol 13:962–972

    Article  CAS  PubMed  Google Scholar 

  271. Moran CA, Wick MR, Suster S (2000) The role of immunohistochemistry in the diagnosis of malignant mesothelioma. Semin Diagn Pathol 17:178–183

    CAS  PubMed  Google Scholar 

  272. Corson JM, Pinkus GS (1982) Mesothelioma: profile of keratin and carcinoembryonic antigen: an immunoperoxidase study of 20 cases and comparison with pulmonary adenocarcinoma. Am J Pathol 108:80–87

    CAS  PubMed  PubMed Central  Google Scholar 

  273. Sheibani K, Battifora H, Burke JS (1986) Antigenic phenotype of malignant mesotheliomas and pulmonary adenocarcinomas: an immunohistologic analysis demonstrating the value of Leu M1 antigen. Am J Pathol 123:212–219

    CAS  PubMed  PubMed Central  Google Scholar 

  274. Metzger J, Lamerz R, Permanetter W (1990) Diagnostic significance of carcinoembryonic antigen in the differential diagnosis of malignant mesothelioma. J Thorac Cardiovasc Surg 100:860–866

    Google Scholar 

  275. Ordonez NG (1999) The immunohistochemical diagnosis of epithelial mesothelioma. Hum Pathol 30:313–323

    Article  CAS  PubMed  Google Scholar 

  276. Ordonez NG (1989) Role of immunohistochemistry in differentiating epithelial mesothelioma from adenocarcinoma: review and update. Am J Clin Pathol 112:75–89

    Article  Google Scholar 

  277. Latza U, Niedobitek G, Schwarting R et al (1990) Ber-Ep4: new monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol 43:213–219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  278. Ordonez NG (1998) Value of the BerEP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma. Am J Clin Pathol 109:85–89

    Article  CAS  PubMed  Google Scholar 

  279. Arber DA, Weiss LM (1993) CD15: a review. Appl Immunohistochem 1:17–30

    CAS  Google Scholar 

  280. Sheibani K, Battifora H, Burke JS (1986) LeuM1 antigen in human neoplasms: an immunohistochemical study of 400 cases. Am J Surg Pathol 10:227–236

    Article  CAS  PubMed  Google Scholar 

  281. Lefebvre MP, Rodriguez F, Schlom J et al (1985) The application of a monoclonal antibody to the differentiation of benign and malignant mesothelial proliferations from adenocarcinoma (abstr). Lab Invest 52:38A

    Google Scholar 

  282. Szpak CA, Johnston WW, Roggli V et al (1986) The diagnostic distinction between malignant mesothelioma of the pleura and adenocarcinoma of the lung as defined by a monoclonal antibody, B72.3. Am J Pathol 122:252–260

    CAS  PubMed  PubMed Central  Google Scholar 

  283. Ordonez NG (1985) The immunohistochemical diagnosis of mesothelioma and lung adenocarcinoma. Am J Surg Pathol 13:276–291

    Google Scholar 

  284. De Leij L, Poppema S, Klein Nulend JK, Ter Harr JG, Schwander E, The TH (1984) Immunoperoxidase staining on frozen tissue sections as a first screening assay in the preparation of monoclonal antibodies directed against small cell carcinoma of the lung. Eur J Cancer Clin Oncol 20:123–128

    Article  PubMed  Google Scholar 

  285. Ordóñez NG (2003) The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol 27:1031–1051

    Article  PubMed  Google Scholar 

  286. Ordóñez NG (2006) The diagnostic utility of immunohistochemistry and electron microscopy in distinguishing between peritoneal mesotheliomas and serous carcinomas: a comparative study. Mod Pathol 19:34–48

    Article  PubMed  CAS  Google Scholar 

  287. Ordóñez NG (2006) The diagnostic utility of immunohistochemistry in distinguishing between epithelioid mesotheliomas and squamous carcinomas of the lung: a comparative study. Mod Pathol 19:417–428

    Article  PubMed  Google Scholar 

  288. Sosolik RC, McGaughy VR, De Young BR (1997) Anti-MOC-31: a potential addition to the pulmonary adenocarcinoma versus mesothelioma immunohistochemistry panel. Mod Pathol 10:716–719

    CAS  PubMed  Google Scholar 

  289. Ordóñez NG (1998) Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal ovarian serous carcinomas. Am J Surg Pathol 22:1203–1214

    Article  PubMed  Google Scholar 

  290. Carella R, Deleonardi G, D’Errico A et al (2001) Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis. Am J Surg Pathol 25:43–50

    Article  CAS  PubMed  Google Scholar 

  291. Oates J, Edwards C (2000) HBME-1, MOC-31, WT1 and calretinin: an assessment of recently described markers for mesothelioma and adenocarcinoma. Histopathology 36:341–347

    Article  CAS  PubMed  Google Scholar 

  292. Ruitenbeek T, Gouw ASH, Poppema S (1994) Immunocytology of body cavity fluids. MOC-31, a monoclonal antibody discriminating between mesothelial and epithelial cells. Arch Pathol Lab Med 118:265–269

    CAS  PubMed  Google Scholar 

  293. Riera JR, Astengo-Osuna C, Longmate JA et al (1997) The immunohistochemical diagnostic panel for epithelial mesothelioma: a reevaluation after heat induced epitope retrieval. Am J Surg Pathol 21:1409–1419

    Article  CAS  PubMed  Google Scholar 

  294. Leong ASY, Vernon-Roberts E (1994) The immunohistochemistry of malignant mesothelioma. Pathol Annu 29:157–159

    PubMed  Google Scholar 

  295. Marshall RJ, Herbert A, Braye SG et al (1984) Use of antibodies to carcinoembryonic antigen and human milk fat globule to distinguish carcinoma, mesothelioma and reactive mesothelium. J Clin Pathol 37:1215–1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  296. Doglioni C, Dei Tos AP, Laurino L et al (1996) Calretinin: a novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 20:1037–1046

    Article  CAS  PubMed  Google Scholar 

  297. Leers MPG, Aarts MMJ, Theunissen PHMH (1998) E-cadherin and calretinin: a useful combination of immunohistochemical markers for differentiation between mesothelioma and metastatic adenocarcinoma. Histopathology 32:209–216

    Article  CAS  PubMed  Google Scholar 

  298. Barberis MCP, Faleri M, Veronese S et al (1997) Calretinin: a selective marker of normal and neoplastic mesothelial cells in serous effusions. Acta Cytol 41:1757–1761

    Article  CAS  PubMed  Google Scholar 

  299. Ordonez NG (1998) Value of calretinin immunostaining in differentiating epithelial mesothelioma from lung adenocarcinoma. Mod Pathol 11:929–933

    CAS  PubMed  Google Scholar 

  300. Amin KM, Litzky LA, Smythe WR et al (1995) Wilms’ tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am J Pathol 146:344–356

    CAS  PubMed  PubMed Central  Google Scholar 

  301. Kumar-Singh S, Segers K, Rodeck U et al (1997) WT1 mutation in malignant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression, cell-type transition, and prognosis. J Pathol 181:67–74

    Article  CAS  PubMed  Google Scholar 

  302. Ordóñez NG (2002) Immunohistochemical diagnosis of epithelioid mesotheliomas: a critical review of old markers, new markers. Hum Pathol 33:953–967

    Article  PubMed  Google Scholar 

  303. Tischoff I, Neid M, Neumann V, Tannapfel A (2011) Pathohistological diagnosis and differential diagnosis. Recent Results Cancer Res 189:57–78

    Article  CAS  PubMed  Google Scholar 

  304. Takeshima Y, Amatya VJ, Kushitani K, Kaneko M, Inai K (2009) Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma. Histopathology 54:667–676

    Article  PubMed  Google Scholar 

  305. Chu AY, Litzky LA, Pasha TL, Acs G, Zhang PJ (2005) Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 18:105–110

    Article  CAS  PubMed  Google Scholar 

  306. Ordóñez NG (2005) D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol 36:372–380

    Article  PubMed  CAS  Google Scholar 

  307. Muller A, Franke F, Muller K (2006) D2-40: a reliable marker in the diagnosis of pleural mesothelioma. Hum Pathol 73:50–54

    Google Scholar 

  308. Collins CL, Ordonez NG, Schaefer R et al (1992) Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am J Pathol 141:827–833

    CAS  PubMed  PubMed Central  Google Scholar 

  309. Ordonez NG (1997) The value of antibodies 44-3A6, SM3, HBME-1, and thrombomodulin in differentiating epithelial pleural mesothelioma from lung adenocarcinoma: a comparative study with other commonly used antibodies. Am J Surg Pathol 21:1399–1408

    Article  CAS  PubMed  Google Scholar 

  310. Sheibani K, Esteban JM, Bailey A, Battifora H, Weiss LM (1992) Immunopathologic and molecular studies as an aid to the diagnosis of malignant mesothelioma. Hum Pathol 23:107–116

    Article  CAS  PubMed  Google Scholar 

  311. Miettinen M, Kobatich AJ (1995) HBME-1: a monoclonal antibody useful in the differential diagnosis of mesothelioma, adenocarcinoma, and soft-tissue and bone tumors. Appl Immunohistochem 3:115–122

    Google Scholar 

  312. Takeichi M (1991) Cadherin cell adhesion receptors as morphogenetic regulators. Science 251:1451–1455

    Article  CAS  PubMed  Google Scholar 

  313. Soler AP, Knudsen KA, Jaurand M-C et al (1995) The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Hum Pathol 26:1363–1369

    Article  Google Scholar 

  314. Ordonez NG (2000) Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesotheliomas from pulmonary and nonpulmonary adenocarcinomas. Am J Surg Pathol 24:598–606

    Article  CAS  PubMed  Google Scholar 

  315. Soler AP, Knudsen KA, Teeson-Miguel A et al (1997) Expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometrioid tumors. Hum Pathol 28:734–739

    Article  Google Scholar 

  316. Bejarano PA, Baughman RP, Biddinger PW et al (1996) Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol 9:445–452

    CAS  PubMed  Google Scholar 

  317. Di Loreto C, Puglisi F, Di Luro V, Damante G, Beltrami CA (1998) TTF-1 protein expression in pleural malignant mesotheliomas and adenocarcinomas of the lung. Cancer Lett 124:73–78

    Article  PubMed  Google Scholar 

  318. Ordóñez N (2012) Napsin A expression in lung and kidney neoplasia. Adv Anat Pathol 19:66–73

    Article  PubMed  CAS  Google Scholar 

  319. Bishop JA, Sharma R, Illei PB (2010) Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol 40:20–25

    Article  CAS  Google Scholar 

  320. Wang NS (1973) Electron microscopy in the diagnosis of pleural mesotheliomas. Cancer 31:1046–1054

    Article  CAS  PubMed  Google Scholar 

  321. Davis JMG (1974) Ultrastructure of human mesotheliomas. J Natl Cancer Inst 52:1715–1725

    Article  CAS  PubMed  Google Scholar 

  322. Dardick I, El-Jabbi M, McCaughey WT et al (1984) Ultrastructure of poorly differentiated diffuse epithelial mesotheliomas. Ultrastruct Pathol 7:151–160

    Article  CAS  PubMed  Google Scholar 

  323. Warhol MJ, Hickey WF, Corson JM (1982) Malignant mesothelioma: ultrastructural distinction from adenocarcinoma. Am J Surg Pathol 6:307–314

    Article  CAS  PubMed  Google Scholar 

  324. Warhol MJ, Corson JM (1985) An ultrastructural comparison of mesotheliomas with adenocarcinomas of the lung and breast. Hum Pathol 16:50–55

    Article  CAS  PubMed  Google Scholar 

  325. Burns TR, Greenberg D, Mace ML, Johnson EH (1985) Ultrastructural diagnosis of epithelial malignant mesothelioma. Cancer 56:2036–2040

    Article  CAS  PubMed  Google Scholar 

  326. Dardick I, El-Jabbi M, McCaughey WT et al (1987) Diffuse epithelial mesothelioma: a review of the ultrastructural spectrum. Ultrastruct Pathol 11:503–533

    Article  CAS  PubMed  Google Scholar 

  327. Oury TD, Hammar SP, Roggli VL (1998) Ultrastructural features of diffuse malignant mesotheliomas. Hum Pathol 29:1382–1392

    Article  CAS  PubMed  Google Scholar 

  328. Dewar A, Valente M, Ring NP et al (1987) Pleural mesothelioma of epithelial type and pulmonary adenocarcinoma: an ultrastructural and cytochemical comparison. J Pathol 152:309–316

    Article  CAS  PubMed  Google Scholar 

  329. Jandik WR, Landas SK, Bray CK, Lager DJ (1993) Scanning electron microscopic distinction of pleural mesotheliomas from adenocarcinomas. Mod Pathol 6:761–764

    CAS  PubMed  Google Scholar 

  330. Burns TR, Johnson EH, Cartwright J, Greenberg SD (1988) Desmosomes of epithelial malignant mesothelioma. Ultrastruct Pathol 12:385–388

    Article  CAS  PubMed  Google Scholar 

  331. Ghadially FN, Rippstein PU et al (1995) Giant desmosomes in tumors. Ultrastruct Pathol 19:469–474

    Article  CAS  PubMed  Google Scholar 

  332. Mukherjee TM, Swift JG, Henderson DW (1988) Freeze-fracture study of intercellular junctions in benign and malignant mesothelial cells in effusions and a comparison with those seen in pleural mesotheliomas (solid tumor). J Submicrosc Cytol Pathol 20:195–208

    CAS  PubMed  Google Scholar 

  333. Ordonez NG (2012) Mesotheliomas with crystalloid structures: report of nine cases, including one with oncocytic features. Mod Pathol 25:272–281

    PubMed  Google Scholar 

  334. Roggli VL, Sanfilippo F, Shelburne JD (1992) Mesothelioma, Ch 5. In: Roggli VL, Greenberg SD, Pratt PC (eds) Pathology of asbestos-associated diseases. Little, Brown & Co, Boston, pp 109–164

    Google Scholar 

  335. Klima M, Bossart MI (1983) Sarcomatous type of malignant mesothelioma. Ultrastruct Pathol 4:349–358

    Article  CAS  PubMed  Google Scholar 

  336. Churg A, Cagle P, Colby TV, Corson JM, Gibbs AR, Hammar S et al (2011) The fake fat phenomenon in organizing pleuritis: a source of confusion with desmoplastic malignant mesotheliomas. Am J Surg Pathol 35:1823–1829

    Article  PubMed  Google Scholar 

  337. Ordonez NG, Ro JY, Ayala AG (1998) Lesions described as nodular mesothelial hyperplasia are primarily composed of histiocytes. Am J Surg Pathol 22:285–292

    Article  CAS  PubMed  Google Scholar 

  338. Taylor DR, Page W, Hughes D, Varghese G (1987) Metastatic renal cell carcinoma mimicking pleural mesothelioma. Thorax 42:901–902

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  339. Ordonez NG (2004) The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Hum Pathol 27:697–710

    Article  CAS  Google Scholar 

  340. Weiss SW, Enzinger FM (1982) Epithelioid hemangioendothelioma: a vascular tumor often mistaken for an adenocarcinoma. Cancer 50:970–981

    Article  CAS  PubMed  Google Scholar 

  341. Dail DH, Liebow AA, Gmelich JT et al (1983) Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT): an analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer 51:452–464

    Article  CAS  PubMed  Google Scholar 

  342. Corrin B, Manners B, Millard M, Weaver L (1979) Histogenesis of the so-called “intravascular bronchioloalveolar tumor”. J Pathol 128:163–167

    Article  CAS  PubMed  Google Scholar 

  343. Miettinen M, Limon J, Niezabitowski A, Lasota J (2001) Calretinin and other mesothelioma markers in synovial sarcoma: analysis of antigenic similarities and differences with malignant mesothelioma. Am J Surg Pathol 25:610–617

    Article  CAS  PubMed  Google Scholar 

  344. Gaertner E, Zeren EH, Fleming MV, Colby TV, Travis WD (1996) Biphasic synovial sarcomas arising in the pleural cavity: a clinicopathologic study of five cases. Am J Surg Pathol 20:36–45

    Article  CAS  PubMed  Google Scholar 

  345. Aubry M-C, Bridge JA, Wickert R, Tazelaar HD (2001) Primary monophasic synovial sarcoma of the pleura: five cases confirmed by the presence of SYT-SSX fusion transcript. Am J Surg Pathol 25:776–781

    Article  CAS  PubMed  Google Scholar 

  346. Matsuyama A, Hisaoke A, Isasaki M, Iwashita M et al (2010) TLE1 expression in malignant mesothelioma. Virchows Arch 457:577–583

    Article  CAS  PubMed  Google Scholar 

  347. Praet M, Forsyth R, Dhaene K, Hermans G, Remmelinck M, Goethem JV, Verbeken E, Weynand B (2002) Synovial sarcoma of the pleura: report of four cases. Histopathology 41(Suppl 2):147–149

    Google Scholar 

  348. De Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A (1995) Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2 in t(8: 18) (p1 1.2:q1 1.2) positive synovial sarcoma. Hum Mol Genet 4:1097–1099

    Article  PubMed  Google Scholar 

  349. Kao SC, Griggs K, Lee K, Armstrong N, Clarke S, Vardy J, van Zandwijk N, Burn J, McCaughan BC, Henderson DW, Klebe S (2011) Validation of a minimal panel of antibodies for the diagnosis of malignant pleural mesothelioma. Pathology 43:313–317

    Article  PubMed  Google Scholar 

  350. Klebe S, Nurminen M, Leigh J, Henderson DW (2009) Diagnosis of epithelial mesothelioma using tree-based regression analysis and a minimal panel of antibodies. Pathology 41:140–148

    Article  CAS  PubMed  Google Scholar 

  351. Yaziji H, Battifora H, Barry TS, Hwang HC, Bacchi CE, McINtosh MW, Kussick SJ, Gown AM (2006) Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. Mod Pathol 19:514–523

    Article  CAS  PubMed  Google Scholar 

  352. Pan C, Chen PC, Chou T, Chiant H (2003) Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymoma. Hum Pathol 34:1155–1162

    Article  CAS  PubMed  Google Scholar 

  353. Attanoos RL, Galateau-Salle F, Gibbs AR, Muller S et al (2002) Primary thymic epithelial tumours of the pleura mimicking malignant mesothelioma. Histopathology 41:42–49

    Article  CAS  PubMed  Google Scholar 

  354. Cury PM, Butcher EN, Corrin B, Nicholson AG (1999) The use of histological and immunohistochemical markers to distinguish pleural malignant mesothelioma and in situ mesothelioma from reactive mesothelial hyperplasia and reactive pleural fibrosis. J Pathol 189:251–257

    Article  CAS  PubMed  Google Scholar 

  355. Saad RS, Cho P, Liu YL, Silverman UF (2003) The value of epithelial membrane antigen expression in separating benign mesothelial proliferation from malignant mesothelioma: a comparative study. Diagn Cytopathol 32:156–159

    Article  Google Scholar 

  356. Attanoos RL, Griffin A, Gibbs AR (2003) The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, p-glycoprotein and bcl-2. Histopathology 43:231–238

    Article  CAS  PubMed  Google Scholar 

  357. Shen J, Pinkus GS, Deshpande V, Cibas E (2009) Usefulness of EMA, GLUT-1, and XIAP for the cytologic diagnosis of malignant mesothelioma in body cavity fluids. Anat Pathol 131:516–523

    CAS  Google Scholar 

  358. Hasteh F, Grace YL, Weidner N, Michael CW (2010) The use of immunohistochemistry to distinguish reactive mesothelial cells from malignant mesothelioma in cytologic effusions. Cancer Cytopathol 118:90–96

    Article  PubMed  Google Scholar 

  359. Kuperman M, Florence RR, Pantanowitz L, Visintainer PF, Cibas ES, Otis CN (2011) Distinguishing benign from malignant mesothelial cells in effusions by glut-1, EMA and desmin expression: an evidence-based approach. Diagn Cytopathol 41(2):131–140

    Article  PubMed  Google Scholar 

  360. Ramael M, Lemmens G, Eerdekens C, Buysse C, Deblier I, Jacovbs W, Van Marck E (1992) Immunoreactivity for p53 protein in malignant mesothelioma and non-neoplastic mesothelium. J Pathol 168:371–375

    Article  CAS  PubMed  Google Scholar 

  361. Kato Y, Tsuta K, Seki K et al (2007) Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol 20:215–220

    Article  CAS  PubMed  Google Scholar 

  362. Monaco SE, Shuai Y, Bansal M, Krasinska AM, Dacic S (2011) The diagnostic utility of p16 FISH and GLUT-1 immunohistochemical analysis in mesothelial proliferations. Am J Clin Pathol 135:619–627

    Article  PubMed  Google Scholar 

  363. Wu M, Sun Y, Li G, Desman G, Wang B, Gil J, Burstein DE (2007) Immunohistochemical detection of XIAP in mesothelium and mesothelial lesions. Am J Clin Pathol 128:783–787

    Article  PubMed  Google Scholar 

  364. Ramael M, Van Den Bossche J, Buysse C, Van Meerbeeck J, Segers K, Vermeire P, Van Marck E (1992) Glycoprotein in malignant mesothelioma and in non-neoplastic mesothelium of the pleura using the murine monoclonal antibody JSB-1. J Pathol 167:5–8

    Article  CAS  PubMed  Google Scholar 

  365. Segers K, Ramael M, Singh S, Van Marck E, Weyler J et al (1994) Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium. Virchows Arch 424:631–634

    Article  CAS  PubMed  Google Scholar 

  366. Salman WD, Eyden B, Shelton D, Howat A, Al-Dawoud A, Twaij Z (2009) An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry? J Clin Pathol 62:651–652

    Article  CAS  PubMed  Google Scholar 

  367. Robinson BW, Creaney J, Lake R, Nowak A, Musk AW, de Klerk N, Winzell P, Hellstrom KE, Hellstrom I (2003) Mesothelin-family proteins and diagnosis of mesothelioma. Lancet 362:1612–1616

    Article  CAS  PubMed  Google Scholar 

  368. Hallevoet K, Van Cleemput J, Thimpont J, De Vuyst P, Bosquee L, Nackaerts K, Germonpre P, Vansteelandt S, Kishi Y, Delanghe JR, van Meerbeeck JP (2011) Serial measurements of mesothelioma serum biomarkers in asbestos-exposed individuals: a prospective longitudinal cohort study. J Thorac Oncol 6:889–895

    Article  Google Scholar 

  369. Hallevoet K, Nackaerts K, Fosselin R, De Wever W, Bosquee L, De Vuyst P, Germonpre P, Kellen E, Legrand C, Kishi Y, Delanghe JR, van Meerbeeck JP (2011) Soluble mesothelin, megakaryocyte potentiating factor and osteopontin as markers of patient response and outcome in mesothelioma. J Thorac Oncol 6:1930–1937

    Article  Google Scholar 

  370. Cristaudo A, Bonotti A, Simonini S, Vivaldi A, Vugleilmi G, Ambrosino N, Chella A, Lucchi M, Mussi A, Foddis R (2011) Combined serum mesothelin and plasma osteopontin measurements in malignant pleural mesothelioma. J Thorac Oncol 6:1587–1594

    Article  PubMed  Google Scholar 

  371. Creaney J, Musk AW, Robinson BW (2010) Sensitivity of urinary mesothelin in patients with malignant mesothelioma. J Thorac Oncol 5:1461–1466

    Article  PubMed  Google Scholar 

  372. Cristaudo A, Foddis R, Bonotti A, Simonini S, Vivaldi A, Guglielmi G, Ambrosino N, Canessa PA, Chella A, Lucchi M, Mussi A, Mutti L (2010) Comparison between plasma and serum osteopontin levels: usefulness in diagnosis of epithelial malignant pleural mesothelioma. Int J Biol Markers 25:164–170

    CAS  PubMed  Google Scholar 

  373. Cristaudo A, Bonotti A, Simonini S, Bruno R, Foddis R (2011) Soluble markers for diagnosis of malignant pleural mesothelioma. Biomark Med 5:261–273

    Article  CAS  PubMed  Google Scholar 

  374. Flores-Staino C, Derai-Ramqvist E, Dobra K, Hierpe A (2010) Adaptation of a commercial fluorescent in situ hybridization test to the diagnosis of malignant cells in effusions. Lung Cancer 68:39–43

    Article  PubMed  Google Scholar 

  375. Chiosea S, Krasinskas A, Cagle PT, Mitchell KA, Zander DS, Dacic S (2008) Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas. Mod Pathol 21:742–747

    Article  CAS  PubMed  Google Scholar 

  376. Christensen BC, Carmen JM, Houseman EA, Godleski JJ, Longacker JL et al (2009) Differentiation of lung adenocarcinoma, pleural mesothelioma and nonmalignant pulmonary tissue using DNA methylation profiles. Cancer Res 69:6315–6321

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  377. Busacca S, Germano S, De Cecco L et al (2010) MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. Am J Respir Cell Mol Biol 42:312–319

    Article  CAS  PubMed  Google Scholar 

  378. Guled M, Lahti L, Lindholm PM, Salmenkivi K, Bagwan I, Nicholson AG, Knuutila S (2009) CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma – a miRNA microarray analysis. Genes Chromosomes Cancer 48:615–623

    Article  CAS  PubMed  Google Scholar 

  379. Benjamin H, Lebanony D, Rosenwald S, Cohen L, Gibori H, Barabash N, Ashkenazi K, Goren E, Meiri E et al (2010) A diagnostic assay based on microRNA expression accurately identifies malignant pleural mesothelioma. J Mol Diagn 12:771–779

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  380. Winslow TJ, Taylor HB (1960) Malignant peritoneal mesotheliomas: a clinicopathological analysis of 12 fatal cases. Cancer 13:127–136

    Article  CAS  PubMed  Google Scholar 

  381. Whitley NO, Brenner DE, Antman KH et al (1982) Computed tomographic evaluation of peritoneal mesothelioma: an analysis of eight cases. Am J Roentgenol 138:531–535

    Article  CAS  Google Scholar 

  382. Fukuda T, Hayashi K, Mori M et al (1991) Radiologic manifestations of peritoneal mesothelioma. Nippon Igaku Hoshasen Gakkai Zasshi 51:643–647

    CAS  PubMed  Google Scholar 

  383. Piccigallo E, Jeffers LJ, Reddy KR, Caldironi MW, Parenti A, Schiff ER (1988) Malignant peritoneal mesothelioma: a clinical and laparoscopic study of ten cases. Dig Dis Sci 33:633–639

    Article  CAS  PubMed  Google Scholar 

  384. Mennemeyer R, Smith M (1979) Multicystic peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer 44:692–698

    Article  CAS  PubMed  Google Scholar 

  385. Moore JH, Crum CP, Chandler JG, Feldman PS (1980) Benign cystic mesothelioma. Cancer 45:2395–2399

    Article  PubMed  Google Scholar 

  386. Weiss SW, Tavassoli FA (1988) Multicystic mesothelioma: an analysis of pathologic findings and biologic behavior in 37 cases. Am J Surg Pathol 12:737–746

    Article  CAS  PubMed  Google Scholar 

  387. Ross MJ, Welsh WR, Scully RE (1989) Multilocular peritoneal inclusion cysts (so called cystic mesothelioma). Cancer 64:1326–1346

    Article  Google Scholar 

  388. Greengard O, Head JF, Chahinian AP, Goldberg SL (1987) Enzyme pathology of human mesotheliomas. J Natl Cancer Inst 78:617–622

    CAS  PubMed  Google Scholar 

  389. Talerman A, Montero JR, Chilcote RR, Okagaki T (1985) Diffuse malignant peritoneal mesothelioma in a 13-year-old girl: report of a case and review of the literature. Am J Surg Pathol 9:73–80

    Article  CAS  PubMed  Google Scholar 

  390. Santucci M, Biancalani M, Dini S (1989) Multicystic peritoneal mesothelioma: a fine structure study with special reference to the spectrum of phenotypic differentiation exhibited by mesothelial cells. J Submicrosc Cytol Pathol 21:749–764

    CAS  PubMed  Google Scholar 

  391. Rosai J (1996) Peritoneum, retroperitoneum, and related structures, Ch 26. In: Rosai J (ed) Ackerman’s surgical pathology, vol 2, 8th edn. Mosby, St. Louis, pp 2135–2172

    Google Scholar 

  392. Gilks CB, Bell DA, Scully RE (1990) Serous psammocarcinoma of the ovary and peritoneum. Int J Gynecol Pathol 9:110–121

    Article  CAS  PubMed  Google Scholar 

  393. Comin CE, Saieva C, Messerini L (2007) h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am J Surg Pathol 31:1139–1148

    Article  PubMed  Google Scholar 

  394. Chu PG, Weiss LM (2002) Expression of cytokeratin 5/6 in epithelial neoplasms: an immunohistochemical study of 509 cases. Mod Pathol 15:6–10

    Article  PubMed  Google Scholar 

  395. Laury AR, Hornick JL, Peters R et al (2010) PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma. Am J Surg Pathol 34:627–635

    PubMed  Google Scholar 

  396. Armstrong GR, Raafat F, Ingram L, Mann JR (1988) Malignant peritoneal mesothelioma in childhood. Arch Pathol Lab Med 112:1159–1162

    CAS  PubMed  Google Scholar 

  397. Kerrigan SAJ, Turnnir RT, Clement PB et al (2002) Diffuse malignant epithelial mesotheliomas of the peritoneum in women: a clinicopathologic study of 25 patients. Cancer 15:378–385

    Article  Google Scholar 

  398. Boffetta P (2007) Epidemiology of peritoneal mesothelioma: a review. Ann Oncol 18:985–990

    Article  CAS  PubMed  Google Scholar 

  399. Hodgson JT, Darnton A (2000) The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure. Ann Occup Hyg 44:565–601

    Article  CAS  PubMed  Google Scholar 

  400. Barbera V, Rubino M (1957) Papillary mesothelioma of the tunica vaginalis. Cancer 10:182–189

    Article  Google Scholar 

  401. Jones MA, Young RH, Scully RE (1995) Malignant mesothelioma of the tunica vaginalis: a clinicopathologic analysis of 11 cases with review of the literature. Am J Surg Pathol 19:815–825

    Article  CAS  PubMed  Google Scholar 

  402. Plas E, Riedl CR, Pflueger H (1998) Malignant mesothelioma of the tunica vaginalis testis: review of the literature and assessment of prognostic parameters. Cancer 83:2437–2446

    Article  CAS  PubMed  Google Scholar 

  403. Japko L, Horta AA, Schreiber K, Mitsudo S, Karwa GL, Singh G, Koss LG (1982) Malignant mesothelioma of the tunica vaginalis testis: report of first case with preoperative diagnosis. Cancer 49:119–127

    Article  CAS  PubMed  Google Scholar 

  404. Brimo F, Illei PB, Epstein JI (2010) Mesothelioma of the tunica vaginalis: a series of eight cases with uncertain malignant potential. Mod Pathol 23:1165–1172

    Article  PubMed  Google Scholar 

  405. Khan MA, Puri P, Devaney D (1997) Mesothelioma of the tunica vaginalis testis in a child. J Urol 158:198–199

    Article  CAS  PubMed  Google Scholar 

  406. Nochomowitz LE, Orenstein JM (1984) Adenocarcinoma of the rete testis: case report, ultrastructural observations and clinicopathologic correlates. Am J Surg Pathol 8:625–634

    Google Scholar 

  407. Taxy JB, Battifor H, Ovasu R (1974) Adenomatoid tumors: a light microscopic, histochemical and ultrastructural study. Cancer 34:306–316

    Article  CAS  PubMed  Google Scholar 

  408. Thompson R, Schlegel W, Lucca M et al (1994) Primary malignant mesothelioma of the pericardium: case report and literature review. Tex Heart Inst J 21:170–174

    Google Scholar 

  409. Vigneswaran WT, Stefanacci PR (2000) Pericardial mesothelioma. Curr Treat Options Oncol 1:299–302

    Article  CAS  PubMed  Google Scholar 

  410. Nomori H, Shimosato Y, Tsuchiya R (1985) Diffuse malignant pericardial mesothelioma. Acta Pathol Jpn 35:1475–1481

    CAS  PubMed  Google Scholar 

  411. Llewellyn MJ, Atkinson MW, Fabri B (1987) Pericardial constriction caused by pericardial mesothelioma. Br Heart J 57:54–57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  412. Nishikimi T, Ochi H, Hirota K, Ikuno Y, Oku H, Takeuchi K, Takeda T (1987) Primary pericardial mesothelioma detected by gallium-67 scintigraphy. J Nucl Med 28:1210–1212

    CAS  PubMed  Google Scholar 

  413. Chung CM, Chu PH, Chen JS, Hsueh C, Chiang CW (1998) Primary pericardial mesothelioma with cardiac tamponade and distant metastasis: case report. Changgeng Yi Xue Za Zhi 21:498–502

    CAS  PubMed  Google Scholar 

  414. Suman S, Schofield P, Large S (2004) Primary pericardial mesothelioma presenting as pericardial constriction: a case report. Heart 90:e4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  415. Maximillian P, Genestreti G, Tassinari D, Lorenzini P, Serra S et al (2005) Malignant pericardial mesothelioma. Report of two cases, review of the literature and differential diagnosis. Tumori 91:276–279

    Google Scholar 

  416. Patel J, Sheppard MN (2011) Primary malignant mesothelioma of the pericardium. Cardiovasc Pathol 20:107–109

    Article  PubMed  Google Scholar 

  417. Gossinger HD, Siostrzonek P, Zangeneh M, Neuhold A, Herold C, Schmoliner R, Laczkovics A, Tscholakoff D, Mosslacher H (1988) Magnetic resonance imaging findings in a patient with pericardial mesothelioma. Am Heart J 115:1321–1322

    Article  CAS  PubMed  Google Scholar 

  418. Naramoto A, Itoh N, Nakano M, Shigematsu H (1989) An autopsy case of tuberous sclerosis associated with primary pericardial mesothelioma. Acta Pathol Jpn 39:400–406

    CAS  PubMed  Google Scholar 

  419. Burke A, Virmani R (1996) Tumors of the heart and great vessels. In: Atlas of tumor pathology. Series 3, Fasc 16. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  420. Smith C (1986) Tumors of the heart. Arch Pathol Lab Med 110:371–374

    CAS  PubMed  Google Scholar 

  421. Linder J, Shelburne JD, Sorge JP, Whalen RE, Hackel DB (1984) Congenital endodermal heterotopia of the atrioventricular node: evidence for the endodermal origin of so-called mesotheliomas of the atrioventricular node. Hum Pathol 15:1093–1098

    Article  CAS  PubMed  Google Scholar 

  422. Sopher IM, Spitz WU (1971) Endodermal inclusions of the heart: so-called mesotheliomas of the atrioventricular node. Arch Pathol 92:180–186

    CAS  PubMed  Google Scholar 

  423. Fine G, Raju U (1987) Congenital polycystic tumor of the atrioventricular node (endodermal heterotopia, mesothelioma): a histogenetic appraisal with evidence for its endodermal origin. Hum Pathol 18:791–795

    Article  CAS  PubMed  Google Scholar 

  424. Beck B, Konetzke G, Ludwig V et al (1982) Malignant pericardial mesotheliomas and asbestos exposure: a case report. Am J Ind Med 3:149–159

    Article  CAS  PubMed  Google Scholar 

  425. Kahn EI, Rohl A, Barnett EW, Suzuki Y (1980) Primary pericardial mesothelioma following exposure to asbestos. Environ Res 23:270–281

    Article  CAS  PubMed  Google Scholar 

  426. Churg A, Warnock ML, Bersch KG (1978) Malignant mesothelioma arising after direct application of asbestos and fiberglass to the pericardium. Am Rev Respir Dis 118:419–424

    CAS  PubMed  Google Scholar 

  427. Roggli VL (1981) Pericardial mesothelioma after exposure to asbestos. N Engl J Med 304:1045

    CAS  PubMed  Google Scholar 

  428. Steele JPC (2002) Prognostic factors in mesothelioma. Semin Oncol 29:36–40

    Article  PubMed  Google Scholar 

  429. Steele JPC, Rudd RM (2000) Malignant mesothelioma: predictors of prognosis and clinical trials. Thorax 55:725–726

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  430. Chahinian AP, Pajak TF, Holland JF, Norton L, Ambinder RM, Mandel EM (1982) Diffuse malignant mesothelioma: prospective evaluation of 69 patients. Ann Intern Med 96:746–755

    Article  CAS  PubMed  Google Scholar 

  431. Ruffie P, Feld R, Minkin S et al (1993) Diffuse malignant mesothelioma of the pleura in Ontario and Quebec: a retrospective study of 188 consecutive patients. Cancer 72:410–417

    Article  Google Scholar 

  432. Spirtas R, Connelly RR, Tucker MA (1988) Survival patterns for malignant mesothelioma: the SEER experience. Int J Cancer 41:525–530

    Article  CAS  PubMed  Google Scholar 

  433. Herndon JE, Green MR, Chahinian AP et al (1998) Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B. Chest 113:723–731

    Article  CAS  PubMed  Google Scholar 

  434. Curran D, Sahmoud T, Therasse P et al (1998) Prognostic factors in patients with pleural mesotheliomas: the European Organization for Research and Treatment of Cancer experience. J Clin Oncol 16:145–152

    Article  CAS  PubMed  Google Scholar 

  435. Edwards JG, Abrams KR, Leverment JN et al (2000) Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic scoring systems. Thorax 55:723–731

    Article  Google Scholar 

  436. Kadota K, Suzuki K, Colovos C, Sima CS, Rusch VW, Travis WD, Adusumilli PS (2012) A nuclear grading system is a strong predictor of survival in epithelioid diffuse malignant pleural mesothelioma. Mod Pathol 25:260–271

    Article  CAS  PubMed  Google Scholar 

  437. Balduyck B, Trousse D, Nakas A, Martin-Ucar AE, Edwards J, Waller DA (2010) Therapeutic surgery for nonepithelioid malignant pleural mesothelioma: is it really worthwhile? Ann Thorac Surg 89:907–911

    Article  PubMed  Google Scholar 

  438. Antman K, Blum R, Greenberger J et al (1980) Multimodality therapy for mesothelioma based on a study of natural history. Am J Med 68:356–362

    Article  CAS  PubMed  Google Scholar 

  439. Christensen BC, Godleski JJ, Roelofs CR, Longacker JL et al (2008) Asbestos burden predicts survival in pleural mesothelioma. Environ Health Perspect 116:723–726

    Article  PubMed  PubMed Central  Google Scholar 

  440. Flores RM, Zakowski M, Venkatraman E, Krug L, Rosenzweig K, Dycoco J (2007) Prognostic factors in the treatment of malignant pleural mesothelioma at a large tertiary referral center. J Thorac Oncol 2:957–965

    Article  PubMed  Google Scholar 

  441. Ceresoli GL, LdeB L, Ferreri AJ et al (2001) Therapeutic outcome according to histologic subtype in 121 patients with malignant pleural mesothelioma. Lung Cancer 34:279–287

    Article  CAS  PubMed  Google Scholar 

  442. Antman KH, Shemin R, Ryan L et al (1988) Malignant mesothelioma: prognostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women’s Hospital experience over two decades 1965-1985. J Clin Oncol 6:147–153

    Article  CAS  PubMed  Google Scholar 

  443. Butchart EG, Ashcroft T, Barnsley WC et al (1976) Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura: experience with 29 patients. Thorax 31:15–24

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  444. Sugarbaker DJ, Flores R, Jacklitsch M et al (1999) Resection margins, extrapleural nodal status and cell type determine post-operative long term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. J Thorac Cardiovasc Surg 117:54–65

    Article  CAS  PubMed  Google Scholar 

  445. Rusch VW (1995) A proposed new international TNM staging system for malignant pleural mesothelioma from the International Mesothelioma Interest Group. Chest 108:1122–1128

    Article  CAS  PubMed  Google Scholar 

  446. Yan TD, Boyer M, Tin MM, Wong D, Kennedy C et al (2009) Extrapleural pneumonectomy for malignant pleural mesothelioma: outcomes of treatment and prognostic factors. J Thorac Cardiovasc Surg 138:619–624

    Article  PubMed  Google Scholar 

  447. Lerner HJ, Schoenfeld DA, Martin AM, Falson G, Borden E (1983) Malignant mesothelioma: The Eastern Cooperative Oncology Group (ECOG) experience. Cancer 52:1981–1985

    Article  CAS  PubMed  Google Scholar 

  448. Moertel C (1972) Peritoneal mesothelioma. Gastroenterology 63:346–350

    CAS  PubMed  Google Scholar 

  449. Antman K, Osteen R, Klegar K et al (1985) Early peritoneal mesothelioma: a treatable malignancy. Lancet 2:977–981

    Article  CAS  PubMed  Google Scholar 

  450. Weissman L, Osteen R, Corson J et al (1988) Combined modality therapy for intraperitoneal mesothelioma (abstr). Proc Am Soc Clin Oncol 7:274

    Google Scholar 

  451. Antman K, Pomfret E, Aisner J et al (1983) Peritoneal mesothelioma: natural history and response to chemotherapy. J Clin Oncol 1:386–391

    Article  CAS  PubMed  Google Scholar 

  452. Sugarbaker PH, Acherman YIZ, Gonzalez-Moreno S, Ortega-Perez G et al (2002) Diagnosis and treatment of peritoneal mesothelioma: the Washington Cancer Institute Experience. Semin Oncol 29:51–61

    Article  PubMed  Google Scholar 

  453. Sporn TA (2008) Primary pleural neoplasms, Ch 33. In: Zander DS, Farver CF (eds) Pulmonary pathology, 1st edn. Churchill Livingstone, Philadelphia, pp 699–717

    Google Scholar 

  454. Roggli VL, Cagle PT (2005) Pleura, pericardium and peritoneum, Ch 19. In: Silverberg SG, DeLellis RL, Frable WJ, LiVolsi VA, Wick M (eds) Principles and practice of surgical pathology and cytopathology, 4th edn. Elsevier, Philadelphia, pp 1005-1039

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Duke Clinics-Duke University Medical Center, 200 Trent Drive, Durham, NC, 27710, USA

    Elizabeth N. Pavlisko MD & Thomas A. Sporn MD

Authors
  1. Elizabeth N. Pavlisko MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas A. Sporn MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elizabeth N. Pavlisko MD .

Editor information

Editors and Affiliations

  1. University of Pittsburgh Dept. Pathology, Pittsburgh, Pennsylvania, USA

    Tim D. Oury

  2. Duke University Medical Center Dept. Pathology, Durham, North Carolina, USA

    Thomas A. Sporn

  3. Duke University Medical Center Dept. Pathology, Durham, North Carolina, USA

    Victor L. Roggli

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Pavlisko, E.N., Sporn, T.A. (2014). Mesothelioma. In: Oury, T., Sporn, T., Roggli, V. (eds) Pathology of Asbestos-Associated Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41193-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-41193-9_5

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-41192-2

  • Online ISBN: 978-3-642-41193-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation