Abstract
Physicochemical parameters are indicators for the identity and purity of a substance. Molecular size, surface charge, lipid and water solubility, vapor pressure, and other properties affect routes of human exposure and toxicokinetics. Volatility and resistance to environmental degradation are important causes of environmental distribution and persistence, and, combined with lipophilicity, they constitute a risk for bioaccumulation. This contribution describes basic physicochemical characteristics and provides examples of their relevance to toxicology.
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References
GHS (2020) Globally harmonized system of classification and labelling of chemicals (GHS). http://www.unece.org/trans/danger/publi/ghs/ghs_rev08/08files_e.html. Last visit 14 Nov 2020
Graham UM, Jacobs G, Yokel RA, Davis BH, Dozier AK, Birch ME, Tseng MT, Oberdorster G, Elder A, DeLouise L (2017) From dose to response: in vivo nanoparticle processing and potential toxicity. Adv Exp Med Biol 947:71–100
ICH (2020) International council for harmonisation: safety guidelines. https://www.ich.org/page/safety-guidelines. Last visit 14 Nov 2020
IUPAC (2020) IUPAC rules for chemical names. https://iupacorg/. Last visit 14 Nov 2020
Kramer A, Hudson PS, Jones MR, Brooks BR (2020) Multi-phase Boltzmann weighting: accounting for local inhomogeneity in molecular simulations of water-octanol partition coefficients in the SAMPL6 challenge. J Comput Aided Mol Des 34(5):471–483
OECD (2020) Test guidelines for chemicals. https://wwwoecdorg/chemicalsafety/testing/oecdguidelinesforthetestingofchemicalshtm. Last visit 14 Nov 2020
Pavel MA, Petersen EN, Wang H, Lerner RA, Hansen SB (2020) Studies on the mechanism of general anesthesia. Proc Natl Acad Sci U S A 117(24):13757–13766
Pozzan A (2020) QM calculations in ADMET prediction. Methods Mol Biol 2114:285–305
Tsuda A, Henry FS, Butler JP (2013) Particle transport and deposition: basic physics of particle kinetics. Compr Physiol 3(4):1437–1471
van Elteren JT, Budic B (2005) A solid-liquid extraction approach to elucidate the chemical availability of metals in soil and sediment assuming Langmuir isotherm behaviour. Talanta 66(4):925–930
Wittmaack K (2007) In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what? Environ Health Perspect 115(2):187–194
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Burger, HJ., Schwenk, M. (2021). Importance of Physicochemical and Physical Properties for Toxicological Risk Assessment. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36206-4_113-2
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DOI: https://doi.org/10.1007/978-3-642-36206-4_113-2
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Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-36206-4
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