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Reactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction

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Systems Biology of Free Radicals and Antioxidants

Abstract

The augmented release of endothelium-derived contracting factor(s) is a hallmark of endothelial dysfunction. The most common endothelium-derived contracting factors (EDCFs) are produced by endothelial cyclooxygenase(s) and cause activation of thromboxane-prostanoid (TP) receptors of the underlying vascular smooth muscle cells. Endothelium-dependent contractions are exacerbated by aging, endothelial regeneration, hypertension, and diabetes. Elevated oxidative stress and the resulting increased production of reactive oxygen species (ROS) are key aspects of cardiovascular disease and play an important role in the occurrence and/or modulation of endothelium-dependent contraction. This present review summarizes the current knowledge on the interactions between ROS and EDCF in the genesis of endothelial dysfunction in animals and humans as a therapeutic target to restore proper endothelial function and slow down the progression of vascular disease.

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Acknowledgments

Y. S. is currently employed in Shanghai Key Laboratory of Organ Transplantation, ZhongShan Hospital, Fudan University. PMV’s research on EDCF is supported by the Research Grant Council of HK (Grant HKU777507M). All results reproduced in the figures were produced in the Department of Pharmacology and Pharmacy, University of Hong Kong, and were supported in part by Research Grants Council Grant HKU 7524 and by the Research Centre of Heart, Brain, Hormonal and Healthy Aging (HBHA) of the University of Hong Kong.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Organ Transplantation, ZhongShan Hospital, Fudan University, FengLin Road 180, 200032, Shanghai, China

    Yi Shi

  2. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

    Paul M. Vanhoutte

  3. Department BIN Fusion Technology, Chonbuk National University, Jeonju, South Korea

    Paul M. Vanhoutte

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Shi, Y., Vanhoutte, P.M. (2014). Reactive Oxygen Species and Endothelium-Derived Contracting Factor (EDCF) – Partners in Endothelial Dysfunction. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_74

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