Zusammenfassung
Im Laufe der letzten Jahrzehnte hat bei der Bevölkerung der westlichen Industrienationen die mittlere Lebenserwartung (Lebenserwartung, die 50 % der Bevölkerung erreichen) stetig zugenommen. Für die im Jahr 2000 Geborenen wird nach neuesten Hochrechnungen ein Anstieg von 65 auf ca. 75 bis 80 Jahre erwartet. Diese Erhöhung ist unabhängig von einer Zunahme der maximalen Lebenserwartung (höchstes Alter, das jemals von einem Menschen erreicht wurde; ◘ Abb. 10.1), die derzeit bei etwa 122 Jahren liegt. Ursache dieser rasanten Entwicklung ist vor allem die permanente Verbesserung der medizinischen Betreuung sowie eine ausgewogenere Ernährung und eine intensivere gesundheitliche Aufklärung der Bevölkerung. Das damit geschaffene Gesundheitsbewusstsein trägt auch zu einem deutlichen Rückgang von Infektionskrankheiten bei.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78:547–581
Benton D (2010) Neurodevelopment and neurodegeneration: are there critical stages for nutritional intervention? Nutr Rev 68 Suppl 1:S6–S10
Cannella C et al. (2009) Nutrition, longevity and behavior. Arch Gerontol Geriatr 49, Suppl 1:19–27
Chance B et al. (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527–605
Charlton KE (2002) Eating well: ageing gracefully! Asia Pac J Clin Nutr 11, Suppl 3:S607–S617
De Jager CA, Kovatcheva A (2010) Summary and discussion: Methodologies to assess long-term effects of nutrition on brain function. Nutr Rev 68 Suppl 1:S53–S58
Everitt AV et al. (2006) Dietary approaches that delay age-related diseases. Clin Interv Aging 1:11–31
Fiala M, Veerhuis R (2010) Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer disease. Exp Gerontol 45:57–63
Grune T (2002) Oxidants and antioxidative defense. Hum Exp Toxicol 21:61–62
Grune T, Davies KJA (2001) Oxidative processes in aging. Handbook of the biology of aging 5. Academic Press, San Diego
Hickson M (2006) Malnutrition and ageing. Postgrad Med J 82:2–8
Isin EM, Guengerich FP (2007) Complex reactions catalyzed by cytochrome P450 enzymes. Biochim Biophys Acta 1770:314–329
Juurlink BH et al. (1998) Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress. Glia 22:371–378
Khaw KT et al. (2001) Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357:657–663
Medvedev ZA (1990) An attempt at a rational classification of theories of ageing. Biol Rev Camb Philos Soc 65: 375–398
Merker K et al. (2001) Proteolysis, caloric restriction and aging. Mech Ageing Dev 122:595–615
Miquel J (2001) Nutrition and ageing. Public Health Nutr 4:1385–1388
Mockett RJ et al. (2001) Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster. Exp Gerontol 36:441–463
Oeseburg H et al. (2010) Telomere biology in healthy aging and disease. Pflugers Arch 459:259–268
Perrig WJ et al. (1997) The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc 45:718–724
Pirlich M et al. (2006) The German hospital malnutrition study. Clin Nutr 25:563–572
Richter T, von Zglinicki T (2007) A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 42:1039–1042
Sano M et al. (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The Alzheimer’s Disease Cooperative Study. N Engl J Med 336:1216–1222
Siems W et al. (1995) Oxidativer Stress und Pharmaka. Govi, Pharmazeutischer Verlag, Eschborn
Shore D, Bianchi A (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. EMBO J 28:2309–2322
Stolzing A et al. (2006) Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material. Free Radic Biol Med 40:2126–2135
Villeponteau B et al. (2000) Nutraceutical interventions may delay aging and the age-related diseases. Exp Gerontol 35:1405–1417
Volkert D (2010) Ernährung im Alter. In: Biessalski HK et al. (Hrsg) Ernährungsmedizin 4. Thieme, Stuttgart
Volkert D et al. (2004) Energy and nutrient intake of young-old, old-old and very-old elderly in Germany. Eur J Clin Nutr 58:1190–1200
Weinstein JR et al. (2010) Microglia in ischemic brain injury. Future Neurol 5:227–246
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Grune, T., Stein, K. (2013). Neurodegeneration und Alterungsprozesse. In: Haller, D., Rimbach, G., Grune, T. (eds) Biofunktionalität der Lebensmittelinhaltsstoffe. Springer-Lehrbuch. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29374-0_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-29374-0_10
Publisher Name: Springer Spektrum, Berlin, Heidelberg
Print ISBN: 978-3-642-29373-3
Online ISBN: 978-3-642-29374-0
eBook Packages: Life Science and Basic Disciplines (German Language)