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Inherited Disorders of Renal Calcium Handling

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Pediatric Nephrology

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Abstract

Human calcium homeostasis is maintained by a complex interplay of different hormonal systems controlling intestinal calcium uptake, renal calcium excretion, and calcium transport in bone and soft tissues. Changes in renal calcium handling may either reflect a renal compensation for disturbances in body calcium homeostasis or its hormonal regulation, or a primary defect in renal tubular calcium transport. Irrespective of the underlying etiology, hypercalciuria represents a major risk factor for renal calcifications and kidney stone disease requiring a thorough diagnostic workup. Especially in infants and young children, hereditary disorders of calcium metabolism and tubular calcium reabsorption have to be considered in the differential diagnosis. The elucidation of the underlying genetic etiology might directly affect the management of affected children.

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Authors and Affiliations

  1. Department of General Pediatrics, Pediatric Nephrology, University Hospital Münster, Münster, Germany

    Karl Peter Schlingmann & Martin Konrad

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  1. Karl Peter Schlingmann
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  2. Martin Konrad
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Correspondence to Karl Peter Schlingmann .

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Editors and Affiliations

  1. Division of Nephrology, Bambino Gesù Children’s Hospital –, ROMA, Roma, Italy

    Francesco Emma

  2. Division of Nephrology and Hypertension The Heart Institute, University of Cincinnati Cincinnati Children’s Hospital Medical C, Cincinnati, OH, USA

    Stuart Goldstein

  3. Division of Nephrology, All India Institute of Medical Sciences, Ansari Nagar East, Delhi, India

    Arvind Bagga

  4. Division of Pediatric Nephrology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA

    Carlton M. Bates

  5. Renal Unit, Graet Ormond Street Hospital, London, UK

    Rukshana Shroff

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Schlingmann, K.P., Konrad, M. (2021). Inherited Disorders of Renal Calcium Handling. In: Emma, F., Goldstein, S., Bagga, A., Bates, C.M., Shroff, R. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27843-3_110-1

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