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The Role of Neuropeptides in Skin Wound Healing

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Textbook of Aging Skin

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Abstract

The skin offers a well suited and clinically relevant model for studying communication between peripheral and central nervous system (CNS), due to its close connection with the brain. A variety of molecules such as neuropeptides, neurohormones, and neurotrophins and their specific receptors are expressed in both neuronal and skin cells, indicating a close functional interaction between the neurons and the skin. The skin acts as a protective barrier against mechanical and chemical damages; therefore, cutaneous innervation plays a critical role in modulating the wound healing process which functions in an orderly and timely manner to rebuild the skin’s integrity and homeostasis. Furthermore, all these neuromediators are involved during all phases of the wound healing process. Neuropeptides circulate between the brain and peripheral tissues and functions as neurotransmitters, neuromodulators, and neurohormones. Neuropeptides have immunoregulatory roles and exhibit mitogenic property, which influence the function of various types of skin cells during the wound healing process.

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Acknowledgments

We would like to thank Ann W. Kinyua (Yonsei University) for the critical reading of this manuscript. This work supported by Small and Medium Business Administration (Technological Innovation R&D Program S2178403) for S. H. M. and the National Research Foundation (NRF-2013R1A1A1007693 and 2014K1A3A1A19066980) for K.W.K.

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Authors and Affiliations

  1. Anti-aging Research Institute of BIO-FD&C Co. Ltd, 21990, Incheon, Republic of Korea

    Yun-Hee Choi & Sanghyun Moh

  2. Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, 26426, Wonju, Republic of Korea

    Ki Woo Kim

  3. Institute of Lifestyle Medicine and Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, 26426, Wonju, Republic of Korea

    Yun-Hee Choi & Ki Woo Kim

Authors
  1. Yun-Hee Choi
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  2. Sanghyun Moh
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  3. Ki Woo Kim
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Correspondence to Ki Woo Kim .

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  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Choi, YH., Moh, S., Kim, K.W. (2015). The Role of Neuropeptides in Skin Wound Healing. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_142-1

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_142-1

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  • Online ISBN: 978-3-642-27814-3

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