Skip to main content

Barium Contrast Radiography and Scintigraphy

  • Chapter
  • First Online:
Esophageal and Gastric Disorders in Infancy and Childhood

Abstract

Several tests are available in clinical practice to detect gastroesophageal reflux disease (GERD), including barium contrast radiography and gastroesophageal scintigraphy. Different studies exist about the specificity, sensitivity, and positive/negative predictive values of barium contrast radiography and scintigraphy, considering pH monitoring as the gold standard for the diagnosis of GERD. Barium contrast radiography is useful for the diagnosis of anatomic abnormalities which may be the cause of symptoms similar to GERD. Scintigraphy with 99technetium is a technique proposed as helpful in detecting reflux, gastric emptying, and microaspiration. However, the sensitivity and specificity of both techniques are much lower than those of pH monitoring. In conclusion, according to the last guidelines on GERD, these techniques are not recommended in the routine diagnosis of GER/GERD, but they can exclude other disorders which can simulate GERD.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Aksglaede K, Pedersen JB, Lange A, et al. Gastro-esophageal reflux demonstrated by radiography in infants less than 1 year of age. Comparison with pH monitoring. Acta Radiol. 2003;44:136–8. 12.

    Article  CAS  PubMed  Google Scholar 

  2. Arasu TS, Wyllie R, Fitzgerald JF, et al. Gastroesophageal reflux in infants and children comparative accuracy of diagnostic methods. J Pediatr. 1980;96:798–803.

    Article  CAS  PubMed  Google Scholar 

  3. Balson BM, Kravitz EK, McGeady SJ. Diagnosis and treatment of gastroesophageal reflux in children and adolescents with severe asthma. Ann Allergy Asthma Immunol. 1998;81:159–64.

    Article  CAS  PubMed  Google Scholar 

  4. Benson JE, Lefton-Greif MA. Videofluoroscopy of swallowing in paediatric patients: a component of the total feeding evaluation. In: Tuchman DN, Walter RS, editors. Disorders of feeding and swallowing in infants and children. San Diego: Singular; 1994. p. 187–2004.

    Google Scholar 

  5. Bingol BA, Funda A, Celmeli F, et al. Does gastroesophageal reflux scintigraphy correlate with clinical findings in children with chronic cough? Nucl Med Commun. 2009;30:802–6.

    Article  Google Scholar 

  6. Boyle JT. Gastroesophageal reflux disease in 2006. Pediatr Radiol. 2006;36 Suppl 2:192–5. 8.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Cameron AJ, Higgins JA. Linear gastric erosion. A lesion associated with large diaphragmatic hernia and chronic blood loss anemia. Gastroenterology. 1986;91:338–42.

    Article  CAS  PubMed  Google Scholar 

  8. Cameron AJ. Barrett’s esophagus: prevalence and size of hiatal hernia. Am J Gastroenterol. 1999;94:2054–9. 26.

    Article  CAS  PubMed  Google Scholar 

  9. Carre IJ, Johnston BT, Thomas PS, et al. Familial hiatal hernia in a large five generation family confirming true autosomal dominant inheritance. Gut. 1999;45:649–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chen YM, Gelfand DW, Ott DJ, et al. Barrett esophagus as an extension of severe esophagitis: analysis of radiologic signs in 29 cases. AJR Am J Roentgenol. 1985;145:275–81.

    Article  CAS  PubMed  Google Scholar 

  11. Christiansen T, Funch-Jensen P, et al. Radiologic quantitation of gastro/oesophageal reflux. Acta Radiol. 1987;28:731–4.

    Article  CAS  PubMed  Google Scholar 

  12. Di Lorenzo C, Piepsz A, Ham H, et al. Gastric emptying with gastro-oesophageal reflux. Arch Dis Child. 1987;62:449–53.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Dibble C, Levine MS, Rubesin SE, et al. Detection of reflux esophagitis on double-contrast esophagrams and endoscopy using the histologic findings as the gold standard. Abdom Imaging. 2004;29:421–5.

    Article  CAS  PubMed  Google Scholar 

  14. Estevao-Costa J, Campos M, Dias JA, et al. Delayed gastric emptying and gastroesophageal reflux: a pathophysiological relationship. J Pediatr Gastroenterol Nutr. 2001;32:471–4.

    Article  CAS  PubMed  Google Scholar 

  15. Fawcett HD, Hayden CK, Adams JC, et al. How useful is gastroesophageal reflux scintigraphy in suspected childhood aspiration? Pediatr Radiol. 1988;18:311–3.

    Article  CAS  PubMed  Google Scholar 

  16. Fisher RE, Malmud LS, Roberts OS, et al. Gastroesophageal (GE) scintiscanning to detect and quantitate GE reflux. Gastroenterology. 1976;70:301–8.

    CAS  PubMed  Google Scholar 

  17. Fransson SG, Sokjer H, Johansson KE, et al. Radiologic diagnosis of gastro-oesophageal reflux by means of graded abdominal compression. Acta Radiol. 1988;29:45–8.

    Article  CAS  PubMed  Google Scholar 

  18. Gatti C, di Abriola FF, Dall’Oglio L, et al. Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in breath test a valid procedure to analyse gastric emptying in children? J Pediatr Surg. 2000;35:62–5.

    Article  CAS  PubMed  Google Scholar 

  19. Ghaed N, Stein MR. Assessment of a technique for scintigraphic monitoring of pulmonary aspiration of gastric contents in asthmatics with gastroesophageal reflux. Ann Allergy. 1979;42:306–8.

    CAS  PubMed  Google Scholar 

  20. Gleeson K, Eggli DF, Maxwell SL. Quantitative aspiration during sleep in normal subjects. Chest. 1997;111:1266–72.

    Article  CAS  PubMed  Google Scholar 

  21. Graziani L, Bearzi I, Romagnoli A, et al. Significance of diffuse granularity and nodularity of the esophageal mucosa at double-contrast radiography. Gastrointes Radiol. 1985;10:1–6.

    Article  CAS  Google Scholar 

  22. Hassall E. Co-morbidities in childhood Barrett’s esophagus. J Pediatr Gastroenterol Nutr. 1997;25:255–60.

    Article  CAS  PubMed  Google Scholar 

  23. Hillemeier AC, Lange R, McCallum R, et al. Delayed gastric emptying in infants with gastroesophageal reflux. J Pediatr. 1981;98:190–3.

    Article  CAS  PubMed  Google Scholar 

  24. Huxley EJ, Viroslav J, Gray WR, et al. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med. 1978;64:564–8.

    Article  CAS  PubMed  Google Scholar 

  25. Jones MP, Sloan SS, Rabine JC, et al. Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease. Am J Gastroenterol. 2001;96:1711–7.

    Article  CAS  PubMed  Google Scholar 

  26. Karaman O, Uzuner N, Degirmenci B, et al. Results of the gastroesophageal reflux assessment in wheezy children. Indian J Pediatr. 1999;66:351–5.

    Article  CAS  PubMed  Google Scholar 

  27. Kazem I. A new scintigraphic technique for the study of the esophagus. AJR. 1972;115:682–8.

    Article  Google Scholar 

  28. Leufer I. Motor disorders of the esophagus. In: Levine MS, editor. Radiology of the esophagus. Philadelphia: WB Saunders; 1989. p. 229–46.

    Google Scholar 

  29. Levine M, Rubens S, Laufer I. Barium esophagography: a study for all seasons. Clin Gastroenterol Hepatol. 2008;6:11–25.

    Article  PubMed  Google Scholar 

  30. Levine M, Rubesin S. Diseases of the esophagus: diagnosis with esophagography. Radiology. 2005;237:414–27.

    Article  PubMed  Google Scholar 

  31. Levine MS, Kressel HY, Caroline DF, et al. Barrett esophagus: reticular pattern of the mucosa. Radiology. 1983;147:663–7.

    Article  CAS  PubMed  Google Scholar 

  32. McVeagh P, Howman-Giles R, Kemp A. Pulmonary aspiration studied by radionuclide milk scanning and barium swallow roentgenography. Am J Dis Child. 1987;141:917–21.

    CAS  PubMed  Google Scholar 

  33. Murray JA, Camilleri M. The fall and rise of the hiatal hernia. Gastroenterology. 2000;119:1779–81.

    Article  CAS  PubMed  Google Scholar 

  34. Orestein SR, Klein HA, Rosenthal MS. Scintigraphy versus pH probe for quantification of pediatric reflux: a study using concurrent multiplexed data and acid feedings. J Nucl Med. 1993;34:1228–34.

    Google Scholar 

  35. Ott DJ. Gastroesophageal reflux: what is the role of barium studies? AJR Am J Roentgenol. 1994;162(3):627–9.

    Article  CAS  PubMed  Google Scholar 

  36. Ott DJ. Motility disorders of the esophagus. In: Gore RM, Levine MS, editors. Textbook of gastrointestinal radiography. 2nd ed. Philadelphia: WB Saunders; 2000. p. 316–28.

    Google Scholar 

  37. Pan JJ, Levine MS, Redfern RO, et al. Gastroesophageal reflux: comparison of barium contrast radiography with 24-h pH monitoring. Eur J Radiol. 2003;47:149–53.

    Article  PubMed  Google Scholar 

  38. Papaila JG, Wilmot D, Grosfeld JL, et al. Increased incidence of delayed gastric emptying in children with gastroesophageal reflux. A prospective evaluation. Arch Surg. 1989;124:933–6.

    Article  CAS  PubMed  Google Scholar 

  39. Piepsz A, Georges B, Perlmutter N, et al. Gastro-esophageal scintiscanning in children. Pediatr Radiol. 1981;11:71–4.

    Article  CAS  PubMed  Google Scholar 

  40. Ravelli AM, Panarotto MB, Verdoni L, et al. Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease. Chest. 2006;130:1520–6.

    Article  PubMed  Google Scholar 

  41. Reyhan M, Yapar AF, Aydin M, et al. gastroesophageal scintigraphy in children: a comparison of posterior and anterior imaging. Ann Nucl Med. 2005;19(1):17–21.

    Article  PubMed  Google Scholar 

  42. Seibert JJ, Byrne WJ, Euler AR, et al. Gastroesophageal reflux the acid test: scintigraphy or the pH probe? AJR Am J Roentgenol. 1983;140:1087–90.

    Article  CAS  PubMed  Google Scholar 

  43. Sellar RJ, DeCaestecker JS, Heading AC. Barium radiology: a sensitive test for gastro-oesophageal reflux. Clin Radiol. 1987;38:303–7.

    Article  CAS  PubMed  Google Scholar 

  44. Simanovsky N, Buonomo C, Nurko S. The infant with chronic vomiting: the value of the upper GI series. Pediatr Radiol. 2002;32:549–50.

    Article  PubMed  Google Scholar 

  45. Thomas EJ, Kumar R, Bharathi J, et al. Gastroesophageal reflux in asthmatic children not responding to asthma medication. A scintigraphic and cklinical findings of reflux. J Clin Imaging. 2003;27:333–6.

    Article  CAS  Google Scholar 

  46. Thompson JK, Koehler RE, Richter JE. Detection of gastroesophageal reflux: value of barium studies compared with 24-h pH monitoring. AJR. 1994;162:621–6.

    Article  CAS  PubMed  Google Scholar 

  47. Tolia V, Kauffman RE. Comparison of evaluation of gastroesophageal reflux in infants sing different feedings during intraesophageal pH monitoring. J Pediatr Gastroenterol Nutr. 1990;10:311–35.

    Google Scholar 

  48. Van Den Driessche M, Peeters K, Marien P, et al. Gastric emptying in formula-fed and breast-fed infants measured with the 13C octanoic acid breath test. J Pediatr Gastroenterol Nutr. 1999;29:46–51.

    Article  Google Scholar 

  49. Vandenplas Y, Derde MP, Piepsz A. Evaluation of reflux episodes during simultaneous esophageal pH monitoring and gastroesophageal reflux scintigraphy in children. J Pediatr Gastroenterol Nulr. 1992;14:256–60.

    Article  CAS  Google Scholar 

  50. Vandenplas Y, Hassall E. Mechanisms of gastroesophageal reflux and gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr. 2002;35:119–36.

    Article  PubMed  Google Scholar 

  51. Vandenplas Y, Rudolph C, Di Lorenzo C, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the north American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). JPGN. 2009;49:498–547.

    PubMed  Google Scholar 

  52. vanWijk MP, Benninga MA, Dent J, et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate. J Pediatr. 2007;151:585–90.

    Article  Google Scholar 

  53. Weir K, McMahon S, Long G, et al. Radiation doses to children during modified barium swallow studies. Pediatr Radiol. 2007;37:283–90. 13.

    Article  PubMed  Google Scholar 

  54. Wenzl TG, Moroder C, Trachterna M, et al. Esophageal pH monitoring and impedance measurement: a comparison of two diagnostic tests for gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 2002;34:511–2.

    Article  Google Scholar 

  55. Wenzl TG, Schenke S, Peschgens T, et al. Association of apnea and nonacid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol. 2001;31:144–9.

    Article  CAS  PubMed  Google Scholar 

  56. Wenzl TG, Silny J, Schenke S, et al. Gastroesophageal reflux and respiratory phenomena in infants: status of the intraluminal impedance technique. J Pediatr Gastroenterol Nutr. 1999;28:423–8.

    Article  CAS  PubMed  Google Scholar 

  57. Wenzl TG. Evaluation of gastroesophageal reflux events in children using multichannel intraluminal electrical impedance. Am J Med. 2003;115(Suppl I):161–5.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Annamaria Staiano MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Turco, R., Ummarino, D., Staiano, A. (2017). Barium Contrast Radiography and Scintigraphy. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_80

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-11202-7_80

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11201-0

  • Online ISBN: 978-3-642-11202-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics