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Bone Scintigraphy: Patterns, Variants, Limitations and Artefacts

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Radionuclide and Hybrid Bone Imaging

Abstract

Radionuclide bone scintigraphy is a highly sensitive investigative tool, routinely used in the evaluation of patients with cancer for suspected bone metastases and in various benign musculoskeletal conditions. Technological innovations such as single photon emission computed tomography (SPECT), positron emission tomography (PET), PET/CT and SPECT/CT have been incorporated into the assessment of various musculoskeletal diseases. One of the limitations of bone scintigraphy is its relatively reduced specificity. Some of the limited specificity can be addressed with a thorough knowledge and experience of normal variants, as well as common patterns of disease, in order to avoid misinterpretation. In this chapter, we discuss the common patterns, variants, artefacts and pitfalls in conventional radionuclide planar, SPECT and hybrid bone SPECT/CT Imaging.

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References

  • Al-Enizi E, Kazem N, Owunwanne A, Collier BD, Mathew M (2003) Dextrose solutions yield radiochemical impurities: the “sweet” scans. J Nucl Med Technol 31(1):33–36

    PubMed  CAS  Google Scholar 

  • Baxter AD, Coakley FV, Finlay DB, West C (1995) The aetiology of solitary hot spots in the ribs on planar bone scans. Nucl Med Commun 16(10):834–837

    Article  PubMed  CAS  Google Scholar 

  • Bombardieri E, Aktolun C, Baum RP, Bishof-Delaloye A, Buscombe J, Chatal JF et al (2003) Bone scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging 30(12):BP99–BP106

    PubMed  Google Scholar 

  • Bunker SR, Handmaker H, Torre DM, Schmidt WP (1990) Pixel overflow artifacts in SPECT evaluation of the skeleton. Radiology 174(1):229–232

    PubMed  CAS  Google Scholar 

  • Bushnell DL, Kahn D, Huston B, Bevering CG (1995) Utility of SPECT imaging for determination of vertebral metastases in patients with known primary tumors. Skeletal Radiol 24(1):13–16

    Article  PubMed  CAS  Google Scholar 

  • Chaudhuri TK (1976) The effect of aluminum and pH on altered body distribution of 99mTc-EHDP. Int J Nucl Med Biol 3(1):37

    Article  PubMed  CAS  Google Scholar 

  • Citrin DL (1977) Problems and limitations of bone scanning with the 99Tcm-phosphates. Clin Radiol 28(1):97–105

    Article  PubMed  CAS  Google Scholar 

  • Coakley FV, Jones AR, Finlay DB, Belton IP (1995) The aetiology and distinguishing features of solitary spinal hot spots on planar bone scans. Clin Radiol 50(5): 327–330

    Article  PubMed  CAS  Google Scholar 

  • Cook GJ, Fogelman I (1999) Skeletal metastases from breast cancer: imaging with nuclear medicine. Semin Nucl Med 29(1):69–79

    Article  PubMed  CAS  Google Scholar 

  • Cook GJ, Fogelman I (2001) The role of nuclear medicine in monitoring treatment in skeletal malignancy. Semin Nucl Med 31(3):206–211

    Article  PubMed  CAS  Google Scholar 

  • Cook GJ, Gnanasegaran G, Chua S (2010) Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med 40(1):52–61

    Article  PubMed  Google Scholar 

  • D’Sa S, Abildgaard N, Tighe J, Shaw P, Hall-Craggs M (2007) Guidelines for the use of imaging in the management of myeloma. Br J Haematol 137(1):49–63

    PubMed  Google Scholar 

  • Damgaard M, Nimb L, Madsen JL (2010) The role of bone SPECT/CT in the evaluation of lumbar spinal fusion with metallic fixation devices. Clin Nucl Med 35(4):234–236

    Article  PubMed  Google Scholar 

  • Delpassand ES, Garcia JR, Bhadkamkar V, Podoloff DA (1995) Value of SPECT imaging of the thoracolumbar spine in cancer patients. Clin Nucl Med 20(12):1047–1051

    Article  PubMed  CAS  Google Scholar 

  • Dogan AS, Rezai K (1993) Incidental lymph node visualization on bone scan due to subcutaneous infiltration of Tc-99m MDP. A potential for false positive interpretation. Clin Nucl Med 18(3):208–209

    Article  PubMed  CAS  Google Scholar 

  • Even-Sapir E, Flusser G, Lerman H, et al (2007) SPECT/multislice low-dose CT: a clinically relevant constituent in the imaging algorithm of nononcologic patients referred for bone scintigraphy. J Nucl Med 48:319–24.

    PubMed  CAS  Google Scholar 

  • Eisner RL, Nowak DJ, Pettigrew R, Fajman W (1986) Fundamentals of 180 degree acquisition and reconstruction in SPECT imaging. J Nucl Med 27(11):1717–1728

    PubMed  CAS  Google Scholar 

  • Fink-Bennett DM, Shapiro EE (1984) The Angle of Louis. A potential pitfall (“Louie’s Hot Spot”) in bone scan interpretation. Clin Nucl Med 9(6):352–354

    Article  PubMed  CAS  Google Scholar 

  • Fogelman I, Maisey M (1988) An atlas of clinical nuclear medicine. Dunitz/C.V. Mosby, London/St. Louis

    Google Scholar 

  • Fogelman I, Bessent RG, Turner JG, Citrin DL, Boyle IT, Greig WR (1978) The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease. J Nucl Med 19(3):270–275

    PubMed  CAS  Google Scholar 

  • Fogelman I, McKillop JH, Gray HW (1983) The “hot patella” sign: is it of any clinical significance? Concise communication. J Nucl Med 24(4):312–315

    PubMed  CAS  Google Scholar 

  • Forstrom LA, Dunn WL, O’Connor MK, Decklever TD, Hardyman TJ, Howarth DM (1996) Technical pitfalls in image acquisition, processing, and display. Semin Nucl Med 26(4):278–294

    Article  PubMed  CAS  Google Scholar 

  • Fournier RS, Holder LE (1998) Reflex Sympathetic Dystrophy: diagnostic controversies. Seminars in Nuclear Medicine 28:116–123

    Article  PubMed  CAS  Google Scholar 

  • Gates GF, Dore EK (1975) Detection of craniosynostosis by bone scanning. Radiology 115(3):665–671

    PubMed  CAS  Google Scholar 

  • Gentili A, Miron SD, Bellon EM (1990) Nonosseous accumulation of bone-seeking radiopharmaceuticals. Radiographics 10(5):871–881

    PubMed  CAS  Google Scholar 

  • Gentili A, Miron SD, Adler LP (1994) Review of some common artifacts in nuclear medicine. Clin Nucl Med 19(2):138–143

    Article  PubMed  CAS  Google Scholar 

  • Gnanasegaran G, Cook GJ, Fogelman I (2007) Musculoskeletal system. In: Biersack HJ, Freeman LM (Eds) Nuclear Medicine Concise. New York Springer

    Article  PubMed  Google Scholar 

  • Gnanasegaran G, Cook G, Adamson K, Fogelman I (2009) Patterns, variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Elsevier Inc. Semin Nucl Med 39(6):380–395

    Article  PubMed  Google Scholar 

  • Han LJ, Au-Yong TK, Tong WC, Chu KS, Szeto LT, Wong CP (1998) Comparison of bone single-photon emission tomography and planar imaging in the detection of vertebral metastases in patients with back pain. Eur J Nucl Med 25(6):635–638

    Article  PubMed  CAS  Google Scholar 

  • Harbert J, Desai R (1985) Small calvarial bone scan foci – normal variations. J Nucl Med 26(10):1144–1148

    PubMed  CAS  Google Scholar 

  • Hassan FU, Mohan HK, Gnanasegaran G, Vijayanathan S, Fogelman I (2011) Beware of the focal uptake at the ischium on the bone scan in prostate cancer. Nucl Med Commun 32(4):320–323

    Article  PubMed  Google Scholar 

  • Hayward JL, Rubens RD, Carbone PP, Heuson JC, Kumaoka S, Segaloff A (1978) Assessment of response to therapy in advanced breast cancer. A project of the programme on clinical oncology of the International Union against Cancer, Geneva, Switzerland. Eur J Cancer 14(11):1291–1292

    Article  PubMed  CAS  Google Scholar 

  • Hirschmann MT, Konala P, Iranpour F, Kerner A, Rasch H, Friederich NF (2011) Clinical value of SPECT/CT for evaluation of patients with painful knees after total knee arthroplasty – a new dimension of diagnostics? BMC Musculoskelet Disord 12:36

    Article  PubMed  Google Scholar 

  • Holder LE, Michael RH (1984) The specific scintigraphic pattern of “shin splints in the lower leg”: concise communication. J Nucl Med 25(8):865–869

    PubMed  CAS  Google Scholar 

  • Horger M, Eschmann SM, Pfannenberg C, Vonthein R, Besenfelder H, Claussen CD et al (2004) Evaluation of combined transmission and emission tomography for classification of skeletal lesions. AJR Am J Roentgenol 183(3):655–661

    PubMed  Google Scholar 

  • Horger M, Eschmann SM, Pfannenberg C, Storek D, Vonthein R, Claussen CD et al (2007) Added value of SPECT/CT in patients suspected of having bone infection: preliminary results. Arch Orthop Trauma Surg 127(3):211–221

    Article  PubMed  Google Scholar 

  • Howarth DM, Forstrom LA, O’Connor MK, Thomas PA, Cardew AP (1996) Patient-related pitfalls and artifacts in nuclear medicine imaging. Semin Nucl Med 26(4):295–307

    Article  PubMed  CAS  Google Scholar 

  • Hughes S, Khan R, Davies R, Lavender P (1978) The uptake by the canine tibia of the bone-scanning agent 99mTc-MDP before and after an osteotomy. J Bone Joint Surg Br 60-B(4):579–582

    PubMed  CAS  Google Scholar 

  • Hung JC, Ponto JA, Hammes RJ (1996) Radio­pharmaceutical-related pitfalls and artifacts. Semin Nucl Med 26(4):208–255

    Article  PubMed  CAS  Google Scholar 

  • Johns WD, Garnick MB, Kaplan WD (1990) Leuprolide therapy for prostate cancer. An association with scintigraphic “flare” on bone scan. Clin Nucl Med 15(7):485–487

    Article  PubMed  CAS  Google Scholar 

  • Kaye J, Hayward M (2002) Soft tissue uptake on 99mTc methylene diphosphonate bone scan imaging: pictorial review. Australas Radiol 46(1):13–21

    Article  PubMed  CAS  Google Scholar 

  • Kessler JR, Wells RG, Sty JR (1992) Skeletal scintigraphy. Radiographic artifacts. Clin Nucl Med 17(6):511–512

    Article  PubMed  CAS  Google Scholar 

  • Kipper MS, Alazraki NP, Feiglin DH (1982) The “hot” patella. Clin Nucl Med 7(1):28–32

    Article  PubMed  CAS  Google Scholar 

  • Kwai AH, Stomper PC, Kaplan WD (1988) Clinical significance of isolated scintigraphic sternal lesions in patients with breast cancer. J Nucl Med 29(3):324–328

    PubMed  CAS  Google Scholar 

  • Loutfi I, Collier BD, Mohammed AM (2003) Nonosseous abnormalities on bone scans. J Nucl Med Technol 31(3):149–153; quiz 54–56

    PubMed  Google Scholar 

  • Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ (2003) Radionuclide bone imaging: an illustrative review. Radiographics 23(2):341–358

    Article  PubMed  Google Scholar 

  • Matin P (1979) The appearance of bone scans following fractures, including immediate and long-term studies. J Nucl Med 20(12):1227–1231

    PubMed  CAS  Google Scholar 

  • McAfee JG, Singh A, Roskopf M, Ritter C, Lyons B, Schoonmaker JE et al (1983) Experimental drug-induced changes in renal function and biodistribution of 99mTc-MDP. Invest Radiol 18(5):470–478

    Article  PubMed  CAS  Google Scholar 

  • McAfee JG, Reba RC, Majid M (1995) The musculoskeletal system. In: Wagner HN, Szabo Z, Buchanan JW (eds) Principles of nuclear medicine, 2nd edn. Saunders, Philadelphia/London

    Google Scholar 

  • McCormick WF (1981) Sternal foramena in man. Am J Forensic Med Pathol 2(3):249–252

    Article  PubMed  CAS  Google Scholar 

  • McKillop JH, Fogelman I (1984) Bone scintigraphy in benign bone disease. Br Med J (Clin Res Ed) 288(6413):264–266

    Article  CAS  Google Scholar 

  • Murray IPC (1998) Vascular Manifestations. In:Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh

    Google Scholar 

  • O’Connor MK (1996) Instrument- and computer-related problems and artifacts in nuclear medicine. Semin Nucl Med 26(4):256–277

    Article  PubMed  Google Scholar 

  • O’Connor MK, Kelly BJ (1990) Evaluation of techniques for the elimination of “hot” bladder artifacts in SPECT of the pelvis. J Nucl Med 31(11):1872–1875

    PubMed  Google Scholar 

  • O’Connor MK, Brown ML, Hung JC, Hayostek RJ (1991) The art of bone scintigraphy – technical aspects. J Nucl Med 32(12):2332–2341

    PubMed  Google Scholar 

  • O’Sullivan JM, Cook GJ (2002) A review of the efficacy of bone scanning in prostate and breast cancer. Q J Nucl Med 46(2):152–159

    PubMed  Google Scholar 

  • Ogawa K (2004) Image distortion and correction in single photon emission CT. Ann Nucl Med 18(3):171–185

    Article  PubMed  Google Scholar 

  • Oswald SG, Vannostrand D, Savory CG et al (1990) The acetabulum, a prospective study of three phase bone and indium white blood cell scintigraphy following coated hip arthroplasty. J Nucl Med 31:274–280

    Article  PubMed  Google Scholar 

  • Pagenstert GI, Barg A, Leumann AG, Rasch H, Muller-Brand J, Hintermann B et al (2009) SPECT-CT imaging in degenerative joint disease of the foot and ankle. J Bone Joint Surg Br 91(9):1191–1196

    Article  PubMed  CAS  Google Scholar 

  • Paterson DC (1970) Myositis ossificans circumscripta. Report of four cases without history of injury. J Bone Joint Surg Br 52(2):296–301

    PubMed  CAS  Google Scholar 

  • Romer W, Nomayr A, Uder M, Bautz W, Kuwert T (2006) SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients. J Nucl Med 47(7):1102–1106

    PubMed  Google Scholar 

  • Rausch JM, Resnick D, Goergen TG, Taylor A (1977) Bone scanning in osteolytic Paget’s disease: case report. J Nucl Med 18:699–701

    PubMed  Google Scholar 

  • Scharf S (2009) SPECT/CT imaging in general orthopedic practice. Semin Nucl Med 39(5):293–307

    Article  PubMed  Google Scholar 

  • Schneider JA, Divgi CR, Scott AM, Macapinlac HA, Seidman AD, Goldsmith SJ et al (1994) Flare on bone scintigraphy following Taxol chemotherapy for metastatic breast cancer. J Nucl Med 35(11):1748–1752

    PubMed  CAS  Google Scholar 

  • Senda K, Itoh S (1987) Evaluation of diffusely high uptake by the calvaria in bone scintigraphy. Ann Nucl Med 1(1):23–26

    Article  PubMed  CAS  Google Scholar 

  • Stokkel MP, Valdes Olmos RA, Hoefnagel CA, Richel DJ (1993) Tumor and therapy associated abnormal changes on bone scintigraphy. Old and new phenomena. Clin Nucl Med 18(10):821–828

    Article  PubMed  CAS  Google Scholar 

  • Storey G, Murray IPC (2004) Bone Scintigraphy:The procedure and interpretation In: Ell PJ, Gambhir SS (eds) Nuclear medicine in clinical diagnosis and treatment, 3rd edn. Churchill Livingstone, New York, Elsevier

    Google Scholar 

  • Tofe AJ, Francis MD, Harvey WJ (1975) Correlation of neoplasms with incidence and localization of skeletal metastases: an analysis of 1,355 diphosphonate bone scans. J Nucl Med 16(11):986–989

    PubMed  CAS  Google Scholar 

  • Tumeh SS, Beadle G, Kaplan WD (1985) Clinical significance of solitary rib lesions in patients with extraskeletal malignancy. J Nucl Med 26(10):1140–1143

    PubMed  CAS  Google Scholar 

  • Utsunomiya D, Shiraishi S, Imuta M, Tomiguchi S, Kawanaka K, Morishita S et al (2006) Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT. Radiology 238(1):264–271

    Article  PubMed  Google Scholar 

  • Wilson MA, Pollack MJ (1981) Gastric visualization and image quality in radionuclide bone scanning: concise communication. J Nucl Med 22(6):518–521

    PubMed  CAS  Google Scholar 

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Correspondence to Malavika Nathan .

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Nathan, M., Gnanasegaran, G., Adamson, K., Fogelman, I. (2012). Bone Scintigraphy: Patterns, Variants, Limitations and Artefacts. In: Fogelman, I., Gnanasegaran, G., van der Wall, H. (eds) Radionuclide and Hybrid Bone Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02400-9_15

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