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Abbreviations
- APR:
-
Acute phase reactant
- AST:
-
Aspartate transaminase
- ALT:
-
Alanine transaminase
- ASGPR:
-
Asialoglycoprotein receptor
- BUdR:
-
Bromodeoxyuridine
- BMT:
-
Bone marrow transplantation
- CTCAE:
-
Common terminology criteria for adverse events
- CLIP:
-
Cancer of the liver Italian program
- CT:
-
Computed tomographic
- DVHs:
-
Dose–volume histograms
- RBCs:
-
Erythrocytes
- FUdR:
-
Fluorodeoxyuridine
- GIT:
-
Gastrointestinal tract
- GSH:
-
Glutathione
- HBV:
-
Hepatitis B virus
- HCC:
-
Hepatocellular carcinoma
- HSC:
-
Hepatic stellate cell
- ICG:
-
Indocyanine Green
- IVC:
-
Inferior vena cava
- IMRT:
-
Intensity modulated radiation therapy
- IORT:
-
Intraoperative radiation therapy
- NTCP:
-
Normal tissue complication probability
- RILD:
-
Radiation-induced liver disease
- RTOG:
-
Radiation Therapy Oncology Group
- RHV:
-
Right hepatic vein
- SECs:
-
Sinusoidal endothelial cells
- SOS:
-
Sinusoidal obstructive syndrome
- SMA:
-
Smooth muscle actin
- SPECT:
-
Single-photon emission computerized tomography
- SBRT:
-
Stereotactic body radiotherapy
- TACE:
-
Transarterial chemo-embolization
- TBI:
-
Total body irradiation
- TGF-β:
-
Transforming growth factor-β
- VOD:
-
Veno-occlusive disease
References
Abrams RA, Cardinale RM, Enger C et al (1997) Influence of prognostic groupings and treatment results in the management of unresectable hepatoma: experience with Cisplatinum-based chemoradiotherapy in 76 patients. Int J Radiat Oncol Biol Phys 39:1077–1085
Alati T, Van Cleeff M, Strom SC et al (1988) Radiation sensitivity of adult human parenchymal hepatocytes. Radiat Res 115:152–160
Alati T, Van Cleeff M, Jirtle RL (1989a) Radiosensitivity of parenchymal hepatocytes as a function of oxygen concentration. Radiat Res 118:488–501
Alati T, Eckl P, Jirtle RL (1989b) An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes. Radiat Res 119:562–568
Amento EP, Beck LS (1991) TGF-beta and wound healing. Ciba Found Symp 157:115–123 discussion 123–129
Anscher MS, Crocker IR, Jirtle RL (1990) Transforming growth factor-beta 1 expression in irradiated liver. Radiat Res 122:77–85
Anscher MS, Peters WP, Reisenbichler H et al (1993a) Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N Engl J Med 328:1592–1598
Anscher MS, Peters WP, Reisenbichler H, Petros WP, Jirtle RL (1993b) N Engl J Med 328:1592–1598
Austin-Seymour MM, Chen GT, Castro JR et al (1986) Dose volume histogram analysis of liver radiation tolerance. Int J Radiat Oncol Biol Phys 12:31–35
Bader TR, Herneth AM, Blaicher W et al (1998) Hepatic perfusion after liver transplantation: noninvasive measurement with dynamic single-section CT. Radiology 209:129–134
Barcellos-Hoff MH (2005a) How tissues respond to damage at the cellular level: orchestration by transforming growth factor-{beta} (TGF-{beta}). BJR Suppl 27:123–127
Barcellos-Hoff MH (2005b) Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage. Semin Cancer Biol 15:138–148
Barcellos-Hoff MH, Park C, Wright EG (2005) Radiation and the microenvironment—tumorigenesis and therapy. Nat Rev Cancer 5:867–875
Bearman SI (2001) Avoiding hepatic veno-occlusive disease: what do we know and where are we going? Bone Marrow Transplant 27:1113–1120
Bearman SI, Anderson GL, Mori M et al (1993) Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation. J Clin Oncol 11:1729–1736
Beetz A, Messer G, Oppel T et al (1997) Induction of interleukin 6 by ionizing radiation in a human epithelial cell line: control by corticosteroids. Int J Radiat Biol 72:33–43
Bjornsson E (2006) Drug-induced liver injury: Hy’s rule revisited. Clin Pharmacol Ther 79:521–528
Blobe GC, Schiemann WP, Lodish HF (2000) Role of transforming growth factor beta in human disease. N Engl J Med 342:1350–1358
Blomgren H, Lax I, Naslund I et al (1995) Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol 34:861–870
Blomley MJ, Coulden R, Dawson P et al (1995) Liver perfusion studied with ultrafast CT. J Comput Assist Tomogr 19:424–433
Borgelt BB, Gelber R, Brady LW et al (1981) The palliation of hepatic metastases: results of the Radiation Therapy Oncology Group pilot study. Int J Radiat Oncol Biol Phys 7:587–591
Brooks SE, Miller CG, McKenzie K et al (1970) Acute veno-occlusive disease of the liver. Fine structure in Jamaican children. Arch Pathol 89:507–520
Bruno S, Maisonneuve P, Castellana P et al (2005) Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial. BMJ 330:932
Burman C, Kutcher GJ, Emami B et al (1991) Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys 21:123–135
Cao Y, Pan C, Balter JM et al (2008) Liver function after irradiation based on computed tomographic portal vein perfusion imaging. Int J Radiat Oncol Biol Phys 70:154–160
Carlini P, Papaldo P, Fabi A et al (2006) Liver toxicity after treatment with gefitinib and anastrozole: drug–drug interactions through cytochrome p450? J Clin Oncol 2006:60–61
Castilla A, Prieto J, Fausto N (1991) Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N Engl J Med 324:933–940
Chalandon Y, Roosnek E, Mermillod B et al (2004) Prevention of veno-occlusive disease with defibrotide after allogeneic stem cell transplantation. Biol Blood Marrow Transplant 10:347–354
Cheng JC, Wu JK, Huang CM et al (2002) Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description. Radiother Oncol 63:41–45
Cheng JC, Wu JK, Huang CM et al (2003) Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease. Int J Radiat Oncol Biol Phys 56:229–234
Cheng JC, Liu MC, Tsai SY et al (2004a) Unexpectedly frequent hepatitis B reactivation by chemoradiation in postgastrectomy patients. Cancer 101:2126–2133
Cheng JC, Liu HS, Wu JK et al (2005) Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease. Int J Radiat Oncol Biol Phys 62:1150–1156
Chiba T, Tokuuye K, Matsuzaki Y et al (2005) Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162 patients. Clin Cancer Res 11:3799–3805
Chou CH, Chen PJ, Lee PH et al (2007) Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells. Clin Cancer Res 13:851–857
Christiansen H, Sheikh N, Saile B et al (2007) X-irradiation in rat liver: consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Radiology 242:189–197
Coeman DC, Verbeken EK, Nackaerts KL et al (2000) A fatal case of cholestatic liver failure probably related to gemcitabine. Ann Oncol 11:1503
Concannon JP, Edelmann A, Frich JC Jr et al (1967) Localized “radiation hepatitis” as demonstrated by scintillation scanning. Radiology 89:136–139
Couinaud C (1992) Anatomie du foie. Ann Ital Chir 63:693–697
Couvelard A, Scoazec JY, Dauge MC et al (1996) Structural and functional differentiation of sinusoidal endothelial cells during liver organogenesis in humans. Blood 87:4568–4580
Davila M, Bresalier R (2008) Gastrointestinal complications of oncologic therapy. Nat Clin Pract Gastroenterol Hepatol 5:682–696
Dawson LA, Ten Haken RK (2005) Partial volume tolerance of the liver to radiation. Semin Radiat Oncol 15:279–283
Dawson LA, Brock KK, Kazanjian S et al (2001) The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy. Int J Radiat Oncol Biol Phys 51:1410–1421
Dawson LA, Eccles C, Bissonnette JP et al (2005a) Accuracy of daily image guidance for hypofractionated liver radiotherapy with active breathing control. Int J Radiat Oncol Biol Phys 62:1247–1252
DeLeve LD (1994) Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther 268:1261–1270
DeLeve LD (1996) Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology 24:830–837
DeLeve LD (1998) Glutathione defense in non-parenchymal cells. Semin Liver Dis 18:403–413
DeLeve LD (2007) Hepatic microvasculature in liver injury. Semin Liver Dis 27:390–400
DeLeve LD, McCuskey RS, Wang X et al (1999) Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology 29:1779–1791
DeLeve LD, Shulman HM, McDonald GB (2002) Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 22:27–42
DeLeve LD, Wang X, Tsai J et al (2003) Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology 125:882–890
Donath D, Nori D, Turnbull A et al (1990) Brachytherapy in the treatment of solitary colrectal metastases to the liver. J Surg Oncol 44:55–61
Emami B, Lyman J, Brown A et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21:109–122
Fajardo LF, Colby TV (1980) Pathogenesis of veno-occlusive liver disease after radiation. Arch Pathol Lab Med 104:584–588
Fedorocko P, Egyed A, Vacek A (2002) Irradiation induces increased production of haemopoietic and proinflammatory cytokines in the mouse lung. Int J Radiat Biol 78:305–313
Ganem G, Saint-Marc GMF, Kuentz M et al (1988) Venocclusive disease of the liver after allogeneic bone marrow transplantation in man. Int J Radiat Oncol Biol Phys 14:879–884
Geraci JP, Mariano MS, Jackson KL (1991) Hepatic radiation injury in the rat. Radiat Res 125:65–72
Goin JE, Salem R, Carr BI et al (2005a) Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: a risk-stratification analysis. J Vasc Interv Radiol 16:195–203
Goin JE, Salem R, Carr BI et al (2005b) Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities. J Vasc Interv Radiol 16:205–213
Gourmelon P, Marquette C, Agay D et al (2005) Involvement of the central nervous system in radiation-induced multi-organ dysfunction and/or failure. BJR Suppl 27:62–68
Gray B, Hazel GV, Hope M et al (2001) Randomised trial of SIR-Spheres plus chemotherapy versus chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol 12:1711–1720
Gushiken F (2000) Peliosis hepatis after treatment with 2-chloro-3′-deoxyadenosine. South Med J 93:625–626
Haddad E, LeBourgeois J, Kuentz M et al (1983) Liver complications in lymphomas treated with a combination of chemotherapy and radiotherapy: preliminary results. Int J Radiat Oncol Biol Phys 9:1313–1319
Hata M, Tokuuye K, Sugahara S et al (2006) Proton beam therapy for hepatocellular carcinoma with limited treatment options. Cancer 107:591–598
Herfarth KK, Debus J, Lohr F et al (2001) Stereotactic single-dose radiation therapy of liver tumors: results of a phase I/II trial. J Clin Oncol 19:164–170
Herfarth KK, Hof H, Bahner ML et al (2003) Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors. Int J Radiat Oncol Biol Phys 57:444–451
Herfarth KK, Debus J, Wannenmacher M (2004) Stereotactic radiation therapy of liver metastases: update of the initial phase-I/II trial. Front Radiat Ther Oncol 38:100–105
Ho C, Davis J, Anderson F et al (2005) Side effects related to cancer treatment: case 1 Hepatitis following treatment with gefitinib. J Clin Oncol 23:8531–8533
Hoefs JC, Chen PT, Lizotte P (2006) Noninvasive evaluation of liver disease severity. Clin Liver Dis 10:535–562, viii–ix
Hosoi Y, Miyachi H, Matsumoto Y et al (2001) Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages. Int J Cancer 96:270–276
Hoyer M, Roed H, Traberg Hansen A et al (2006) Phase II study on stereotactic body radiotherapy of colorectal metastases. Acta Oncol 45:823–830
Iguchi T, Sato S, Kouno Y et al (2003) Comparison of Tc-99m-GSA scintigraphy with hepatic fibrosis and regeneration in patients with hepatectomy. Ann Nucl Med 17:227–233
Ingold J, Reed G, Kaplan H (1965) Radiation hepatitis. Am J Roentgenol 93:200–208
Ishihara H, Tsuneoka K, Dimchev AB et al (1993) Induction of the expression of the interleukin-1 beta gene in mouse spleen by ionizing radiation. Radiat Res 133:321–326
Jackson A, Ten Haken RK, Robertson JM et al (1995) Analysis of clinical complication data for radiation hepatitis using a parallel architecture model. Int J Radiat Oncol Biol Phys 31:883–891
Jeffrey RB Jr, Moss AA, Quivey JM et al (1980) CT of radiation-induced hepatic injury. AJR Am J Roentgenol 135:445–448
Jirtle RL, Michalopoulos G, McLain JR et al (1981) Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation. Cancer Res 41:3512–3518
Jirtle RL, McLain JR, Strom SC et al (1982) Repair of radiation damage in noncycling parenchymal hepatocytes. Br J Radiol 55:847–851
Jirtle RL, Michalopoulos G, Strom SC et al (1984) The survival of parenchymal hepatocytes irradiated with low and high LET radiation. Br J Cancer Suppl 6:197–201
Jirtle R, Anscher M, Alati T (1990) Radiation sensitivity of the liver. Adv Radiat Biol 14:269–311
Jungermann K (1988) Metabolic zonation of liver parenchyma. Semin Liver Dis 8:329–341
Kavanagh BD, Schefter TE, Cardenes HR et al (2006) Interim analysis of a prospective phase I/II trial of SBRT for liver metastases. Acta Oncol 45:848–855
Kawashima M, Furuse J, Nishio T et al (2005) Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol 23:1839–1846
Kennedy AS, Nutting C, Coldwell D et al (2004) Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys 60:1552–1563
Kennedy AS, Coldwell D, Nutting C et al (2006) Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience. Int J Radiat Oncol Biol Phys 65:412–425
Khalil N (1999) TGF-beta: from latent to active. Microbes Infect 1:1255–1263
Kim TH, Kim DY, Park JW et al (2007) Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 67:225–231
King PD, Perry MC (2001) Hepatotoxicity of chemotherapy. Oncologist 6:162–176
Kinzie J, Studer RK, Perez B et al (1972) Noncytokinetic radiation injury: anticoagulants as radioprotective agents in experimental radiation hepatitis. Science 175:1481–1483
Klinger M, Eipeldauer S, Hacker S et al (2009) Bevacizumab protects against sinusoidal obstruction syndrome and does not increase response rate in neoadjuvant XELOX/FOLFOX therapy of colorectal cancer liver metastases. Eur J Surg Oncol 35:515–520
Kopetz S, Vauthey JN (2008) Perioperative chemotherapy for resectable hepatic metastases. Lancet 371:963–965
Lawrence TS, Ten Haken RK, Kessler ML et al (1992) The use of 3-D dose volume analysis to predict radiation hepatitis. Int J Radiat Oncol Biol Phys 23:781–788
Lawrence TS, Robertson JM, Anscher MS et al (1995) Hepatic toxicity resulting from cancer treatment [Review] [64 refs]. Int J Radiat Oncol Biol Phys 31:1237–1248
Ley K (1996) Molecular mechanisms of leukocyte recruitment in the inflammatory process. Cardiovasc Res 32:733–742
Lightdale CJ, Wasser J, Coleman M et al (1979) Anticoagulation and high dose liver radiation: a preliminary report. Cancer 43:174–181
Linard C, Ropenga A, Vozenin-Brotons MC et al (2003) Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layer. Am J Physiol Gastrointest Liver Physiol 285:G556–G565
Llovet JM, Ricci S, Mazzaferro V et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378–390
Lyman JT (1985) Complication probability as assessed from dose-volume histograms. Radiat Res Suppl 8:S13–S19
Materne R, Van Beers BE, Smith AM et al (2000) Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model. Clin Sci (Lond) 99:517–525
Meeren AV, Bertho JM, Vandamme M et al (1997) Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells. Mediators Inflamm 6:185–193
Mehendale HM (2005) Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 33:41–51
Mendez RA, Wunderink W, Hussain SM et al (2006) Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase i–ii study. Acta Oncol 45:831–837
Miles KA (1991) Measurement of tissue perfusion by dynamic computed tomography. Br J Radiol 64:409–412
Miles KA, Hayball M, Dixon AK (1991) Colour perfusion imaging: a new application of computed tomography. Lancet 337:643–645
Miles KA, Hayball MP, Dixon AK (1993) Functional images of hepatic perfusion obtained with dynamic CT. Radiology 188:405–411
Moriconi F, Christiansen H, Raddatz D et al (2008) Effect of radiation on gene expression of rat liver chemokines: in vivo and in vitro studies. Radiat Res 169:162–169
Neff R, Abdel-Misih R, Khatri J et al (2008) The toxicity of liver directed yttrium-90 microspheres in primary and metastatic liver tumors. Cancer Invest 26:173–177
Ogata K, Hizawa K, Yoshida M et al (1963) Hepatic injury following irradiation–a morphologic study. Tokushima J Exp Med 43:240–251
Ogawa Y, Murata Y, Nishioka A et al (1998) Tamoxifen-induced fatty liver in patients with breast cancer. Lancet 351:725
Ohara K, Okumura T, Tsuji H et al (1997) Radiation tolerance of cirrhotic livers in relation to the preserved functional capacity: analysis of patients with hepatocellular carcinoma treated by focused proton beam radiotherapy. Int J Radiat Oncol Biol Phys 38:367–372
Order S, Donaldson S (2003) Hemangiomas, radiation therapy of benign diseases—a clinical guide, 2nd edn. Springer, Berlin, pp 133–134
Ostapowicz G, Fontana RJ, Schiodt FV et al (2002) Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 137:947–954
Park HC, Seong J, Han KH et al (2002) Dose-response relationship in local radiotherapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 54:150–155
Pawlik TM, Olino K, Gleisner AL et al (2007) Preoperative chemotherapy for colorectal liver metastases: impact on hepatic histology and postoperative outcome. J Gastrointest Surg 11:860–868
Perez C, Korba A, Zivnuska F et al (1978) 60Co moving strip technique in the management of the ovary: analysis of tumor control and morbidity. Int J Radiat Oncol Biol Phys 4:279–388
Peters AM, Brown J, Hartnell GG et al (1987a) Non-invasive measurement of renal blood flow with 99mTc DTPA: comparison with radiolabelled microspheres. Cardiovasc Res 21:830–834
Peters AM, Gunasekera RD, Lavender JP et al (1987b) Noninvasive measurement of renal blood flow using DTPA. Contrib Nephrol 56:26–30
Phillips R, Karnofsku D, Hamilton L et al (1954) Roentgen therapy of hepatic metastases. Am J Roengenol 71:826
Rahmouni A, Montazel JL, Golli M et al (1992) Unusual complication of liver irradiation: acute thrombosis of a main hepatic vein: CT and MR imaging features. Radiat Med 10:163–166
Ramadori G, Armbrust T (2001) Cytokines in the liver. Eur J Gastroenterol Hepatol 13:777–784
Rappaport AM (1976) The microcirculatory acinar concept of normal and pathological hepatic structure. Beitrage zur Pathologie 157:215–243
Reiss U, Cowan M, McMillan A et al (2002) Hepatic venoocclusive disease in blood and bone marrow transplantation in children and young adults: incidence, risk factors, and outcome in a cohort of 241 patients. J Pediatr Hematol Oncol 24:746–750
Ricke J, Wust P, Stohlmann A et al (2004) CT-guided interstitial brachytherapy of liver malignancies alone or in combination with thermal ablation: phase I-II results of a novel technique. Int J Radiat Oncol Biol Phys 58:1496–1505
Robinson K, Lambiase L, Li J et al (2003) Fatal cholestatic liver failure associated with gemcitabine therapy. Dig Dis Sci 48:1804–1808
Rodriguez-Frias EA, Lee WM (2007) Cancer chemotherapy II: atypical hepatic injuries. Clin Liver Dis 11:663–676, viii
Rollins BJ (1986) Hepatic veno-occlusive disease. Am J Med 81:297–306
Rosenthal J, Sender L, Secola R et al (1996) Phase II trial of heparin prophylaxis for veno-occlusive disease of the liver in children undergoing bone marrow transplantation. Bone Marrow Transplant 18:185–191
Rubin P, Levitt SH (1964) The response of disseminated reticulum cell sarcoma to the intravenous injection of colloidal radioactive gold. J Nucl Med Off Publ Soc Nucl Med 5:581–594
Russell AH, Clyde C, Wasserman TH et al (1993) Accelerated hyperfractionated hepatic irradiation in the management of patients with liver metastases: results of the RTOG dose escalating protocol. Int J Radiat Oncol Biol Phys 27:117–123
Saif MW (2008) Hepatic failure and hepatorenal syndrome secondary to erlotinib. Safety reminder. J Pancreas 9:748–752
Sartori MT, Spiezia L, Cesaro S et al (2005) Role of fibrinolytic and clotting parameters in the diagnosis of liver veno-occlusive disease after hematopoietic stem cell transplantation in a pediatric population. Thromb Haemost 93:682–689
Schacter L, Crum E, Spitzer T et al (1986) Fatal radiation hepatitis: a case report and review of the literature. Gynecol Oncol 24:373–380
Schefter TE, Kavanagh BD, Timmerman RD et al (2005) A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases. Int J Radiat Oncol Biol Phys 62:1371–1378
Sempoux C, Horsmans Y, Geubel A et al (1997) Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event. Hepatology 26:128–134
Seong J, Park HC, Han KH et al (2003) Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: a retrospective study of 158 patients. Int J Radiat Oncol Biol Phys 55:329–336
Seong J, Shim SJ, Lee IJ et al (2007) Evaluation of the prognostic value of Okuda, cancer of the liver Italian program, and Japan integrated staging systems for hepatocellular carcinoma patients undergoing radiotherapy. Int J Radiat Oncol Biol Phys 67:1037–1042
Sessa C, Aamdal S, Wolff I et al (1994) Gemcitabine in patients with advanced malignant melanoma or gastric cancer: phase II studies of the EORTC Early Clinical Trials Group. Ann Oncol 5:471–472
Shulman HM, McDonald GB, Matthews D et al (1980) An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology 79:1178–1191
Shulman HM, Gown AM, Nugent DJ (1987) Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules. Am J Pathol 127:549–558
Shulman HM, Fisher LB, Schoch HG et al (1994) Veno-occlusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms. Hepatology 19:1171–1181
Simon M, Hahn T, Ford LA et al (2001) Retrospective multivariate analysis of hepatic veno-occlusive disease after blood or marrow transplantation: possible beneficial use of low molecular weight heparin. Bone Marrow Transplant 27:627–633
Sindelar WF, Tepper J, Travis EL (1982) Tolerance of bile duct to intraoperative irradiation. Surgery 92:533–540
Speeg KV, Bay MK (1995) Prevention and treatment of drug-induced liver disease. Gastroenterol Clin North Am 24:1047–1064
Stubbs RS, Cannan RJ, Mitchell AW (2001) Selective internal radiation therapy (SIRT) with 90Yttrium microspheres for extensive colorectal liver metastases. Hepatogastroenterology 48:333–337
Tabbara IA, Zimmerman K, Morgan C et al (2002) Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med 162:1558–1566
Ten Haken RK, Martel MK, Kessler ML et al (1993) Use of Veff and iso-NTCP in the implementation of dose escalation protocols. Int J Radiat Oncol Biol Phys 27:689–695
Ten Haken RK, Lawrence TS, Dawson LA (2006) Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma: in regards to Xu et al. (Int J Radiat Oncol Biol Phys 65:189–195). Int J Radiat Oncol Biol Phys 66:1272; author reply 1272–1273, 2006
Thomas DS, Nauta RJ, Rodgers JE et al (1993) Intraoperative high-dose rate interstitial irradiation of hepatic metastases from colorectal carcinoma. Results of a phase I-II trial. Cancer 71:1977–1981
Tian JH, Xu BX, Zhang JM et al (1996) Ultrasound-guided internal radiotherapy using yttrium-90-glass microspheres for liver malignancies. J Nucl Med 37:958–963
Todoroki T (1978) The late effects of single massive iradiation with electrons of the liver hilum of rabbits. Jpn J Gastrioentereol Surg 11:169–177
Tsai SL, Chen PJ, Lai MY et al (1992) Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest 89:87–96
Tse RV, Hawkins M, Lockwood G et al (2008) Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol 26:657–664
Uematsu M, Shioda A, Suda A et al (2000) Intrafractional tumor position stability during computed tomography (CT)-guided frameless stereotactic radiation therapy for lung or liver cancers with a fusion of CT and linear accelerator (FOCAL) unit. Int J Radiat Oncol Biol Phys 48:443–448
Unger EC, Lee JK, Weyman PJ (1987) CT and MR imaging of radiation hepatitis. J Comput Assist Tomogr 11:264–268
Vauthey JN, Pawlik TM, Ribero D et al (2006) Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 24:2065–2072
Welsh JS, Kennedy AS, Thomadsen B (2006) Selective internal radiation therapy (SIRT) for liver metastases secondary to colorectal adenocarcinoma. Int J Radiat Oncol Biol Phys 66:S62–S73
Welsh FK, Tilney HS, Tekkis PP et al (2007) Safe liver resection following chemotherapy for colorectal metastases is a matter of timing. Br J Cancer 96:1037–1042
Wharton JT, Delclos L, Gallager S et al (1973) Radiation hepatitis induced by abdominal irradiation with the cobalt 60 moving strip technique. Am J Roentgenol Radium Ther Nucl Med 117:73–80
Wu DH, Liu L, Chen LH (2004) Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma. World J Gastroenterol 10:2184–2189
Xu ZY, Liang SX, Zhu J et al (2006) Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma. Int J Radiat Oncol Biol Phys 65:189–195
Yaes RJ, Kalend A (1988) Local stem cell depletion model for radiation myelitis. Int J Radiat Oncol Biol Phys 14:1247–1259
Yamada K, Izaki K, Sugimoto K et al (2003) Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 57:113–119
Yeo W, Chan PK, Zhong S et al (2000) Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol 62:299–307
Zorzi D, Laurent A, Pawlik TM et al (2007) Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg 94:274–286
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Cheng JC, Wu JK, Lee PC et al (2004b) Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease. Int J Radiat Oncol Biol Phys 60:1502–1509
Dawson LA, Normolle D, Balter JM et al (2002) Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 53:810–821
Dawson LA, Biersack M, Lockwood G et al (2005b) Use of principal component analysis to evaluate the partial organ tolerance of normal tissues to radiation. Int J Radiat Oncol Biol Phys 62:829–837
Liang SX, Zhu XD, Xu ZY et al (2006) Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys 65:426–434
Pan C, Kavanagh B, Dawson L et al (2008) Radiation-associated liver injury. Int J Radiat Oncol Biol Phys
Reed G, Cox A (1966) The human liver after radiation injury. A form of veno-occlusive disease. Am J Pathol 48:597–611
Acknowledgments
Thanks to Dr Mark Lee and Dr. Catherine Coolens for their thoughtful comments on this chapter.
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Dawson, L.A., Adeyi, O., Horgan, A., Guha, C. (2014). Liver. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT • Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75863-1_15
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