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Lesion-Symptom Mapping of the Human Cerebellum

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Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

Although the function of the cerebellum cannot be inferred from lesion data alone, it is still of major scientific and clinical interest to assess whether lesions of a given cerebellar area lead to specific behavioral deficits. The introduction of high-resolution structural brain imaging and new analysis methods has led to significant improvement in the ability to draw such conclusions. Lesion-symptom mapping is now possible with a spatial resolution at the level of individual lobules and nuclei of the cerebellum. The investigation of patients with defined focal lesions yields the greatest potential for obtaining meaningful correlations between lesion site and behavioral deficits. In smaller groups of patients, overlay plots and subtraction analysis are good options. If larger groups of patients are accessible, different statistical techniques are available to compare behavior and lesion site on a voxel-by-voxel basis. Although localization in degenerative cerebellar disorders is less accurate because of the diffuse nature of the disease, advanced volumetric and statistical methods provide meaningful information about the functional subdivisions of the cerebellum. This chapter highlights the current developments of lesion-symptom mapping in human cerebellar lesion studies. Examples show that meaningful correlations between lesion site and behavioral data can be obtained both in patients with degenerative as well as focal cerebellar disorders.

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Authors and Affiliations

  1. Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Essen, Germany

    Dagmar Timmann & Michael Küper

  2. Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria

    Elke R. Gizewski

  3. Stiftungsklinikum Mittelrhein GmbH, Koblenz, Germany

    Beate Schoch

  4. Department of Biomedical Engineering and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Be’er Sheva, Israel

    Opher Donchin

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  1. Dagmar Timmann
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  2. Michael Küper
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  3. Elke R. Gizewski
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  4. Beate Schoch
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  5. Opher Donchin
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Correspondence to Dagmar Timmann .

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Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  2. CHU-Charleroi, University of Mons, UMons, Charleroi, Belgium

    Mario U. Manto

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Timmann, D., Küper, M., Gizewski, E.R., Schoch, B., Donchin, O. (2020). Lesion-Symptom Mapping of the Human Cerebellum. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_72-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-97911-3

  • Online ISBN: 978-3-319-97911-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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