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Granule Cell Migration and Differentiation

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Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

The developing cerebellum granule cells migrate from their birthplace to their final destination. The active translocation of granule cells is essential for the formation of a well-organized cerebellar cortex. In this chapter, we will review (1) how granule cells migrate from their origin to their resident destination in the developing cerebellum, (2) the cellular and molecular mechanisms underlying granule cell migration, (3) how exposure to toxic chemicals and natural environmental factors affects the migration of granule cells, and (4) the cellular and molecular mechanisms underlying the differentiation of postmigratory granule cells.

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Authors and Affiliations

  1. Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Yutaro Komuro

  2. Faculty of Health and Medical Sciences, Tokoha University, Hamamatsu, Shizuoka, Japan

    Tatsuro Kumada

  3. Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan

    Nobuhiko Ohno

  4. Division of Ultrastructural Research, National Institute for Physiological Sciences, Okazaki, Aichi, Japan

    Nobuhiko Ohno

  5. Research Support Core, Clinical Research Center, University Hospitals, Cleveland, OH, USA

    Jennifer K. Fahrion

  6. Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Kathryn D. Foote & Kathleen B. Fenner

  7. Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, Neuropeptides, Neuronal Death and Cell Plasticity Team, Normandie University, UNIROUEN, Inserm, Rouen, France

    David Vaudry

  8. Normandie University, UNIROUEN, Inserm, PRIMACEN, Rouen, France

    David Vaudry & Ludovic Galas

  9. Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA

    Hitoshi Komuro

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  1. Yutaro Komuro
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  2. Tatsuro Kumada
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  3. Nobuhiko Ohno
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  4. Jennifer K. Fahrion
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  5. Kathryn D. Foote
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  6. Kathleen B. Fenner
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  7. David Vaudry
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  8. Ludovic Galas
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  9. Hitoshi Komuro
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Corresponding author

Correspondence to Yutaro Komuro .

Editor information

Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

  2. Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

  3. Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

  4. Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, USA

    Roy V. Sillitoe

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Komuro, Y. et al. (2020). Granule Cell Migration and Differentiation. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_7-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_7-2

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  • Print ISBN: 978-3-319-97911-3

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