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Intracellular Membrane Trafficking: Modeling Local Movements in Cells

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Cell Movement

Abstract

Cells constantly exchange material and information with their environment through a variety of trafficking mechanisms. Membrane trafficking encompasses a broad range of biological processes, all of which are characterized by the local deformation and movement of the plasma membrane. These movements are orchestrated by a complex protein machinery and cytoskeletal rearrangements. While different membrane trafficking pathways use different sets of proteins, mathematical and computational models have been used with great success to identify some of the governing physical principles. Here, we review the different theoretical and computational models of local movements in cells and the insights obtained from them. We will also highlight the challenges in the field and discuss future directions.

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Acknowledgements

The authors would like to acknowledge discussions with their many colleagues over the years that have contributed to the development of ideas in this chapter. They would also like to acknowledge the following grants: NSF PHY1505017, ARO W911NF-16-1-041, ONR N00014-17-1-2628 to PR, FISP G-3081 to RV, and an Arnold O. Beckman Postdoctoral Fellowship to MA. They would also like to acknowledge members of the Rangamani and Drubin labs for their feedback on the manuscript. J.S. acknowledges a Moore/Sloan Data science Fellowship from the Siebel Stem Cell Institute–UC Berkeley.

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  1. University of California, San Diego, 9500 Gilman Dr, 92093, La Jolla, CA, USA

    Ritvik Vasan & Padmini Rangamani

  2. Department of Molecular and Cell Biology, University of California, 94720, Berkeley, CA, USA

    Matthew Akamatsu & Johannes Schöneberg

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  1. Mathematics, University of St. Thomas, Saint Paul, MN, USA

    Magdalena Stolarska

  2. Mathematics, Purdue University Northwest, Hammond, IN, USA

    Nicoleta Tarfulea

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Vasan, R., Akamatsu, M., Schöneberg, J., Rangamani, P. (2018). Intracellular Membrane Trafficking: Modeling Local Movements in Cells. In: Stolarska, M., Tarfulea, N. (eds) Cell Movement. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-96842-1_9

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