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Bioanalytical Chemistry of Selenium

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Selenium

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

Selenium (Se) is an interesting element for bioanalytical chemists. Se forms Se-containing compounds having Se-carbon covalent bond(s), i.e., selenometabolites in its metabolic pathway. In this chapter, the analytical techniques for the speciation and identification of unique selenometabolites in animals are highlighted. First, the instruments required for analyses are overviewed. In particular, hyphenated techniques consisting of high-performance liquid chromatography and inductively coupled plasma (tandem) mass spectrometry (ICP-MS) or electrospray ionization (tandem) mass spectrometry are focused on. Second, laser ablation hyphenated with ICP-MS for Se imaging is briefly overviewed. Then, advanced techniques of nuclear magnetic resonance (NMR) spectroscopy for Se analysis are mentioned with an application to a biological sample.

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Acknowledgments

This study was supported by JSPS KAKENHI Grant Numbers 24659022, 26293030, 15K14991, and 16H05812, and a grant from the Food Safety Commission, Cabinet Office, Government of Japan (Research Program for Risk Assessment Study on Food Safety, No 1601).

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Authors and Affiliations

  1. Laboratory of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

    Yasumitsu Ogra & Noriyuki Suzuki

  2. Laboratory of Health Chemistry, Showa Pharmaceutical Sciences, Tokyo, Japan

    Yasumi Anan

Authors
  1. Yasumitsu Ogra
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  2. Yasumi Anan
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  3. Noriyuki Suzuki
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Correspondence to Yasumitsu Ogra .

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Editors and Affiliations

  1. Research Unit: Analytical BioGeoChemistry, Helmholtz Zentrum München – German Research Center for Environmental Health GmbH, Neuherberg, Germany

    Bernhard Michalke

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Ogra, Y., Anan, Y., Suzuki, N. (2018). Bioanalytical Chemistry of Selenium. In: Michalke, B. (eds) Selenium. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-319-95390-8_25

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