Skip to main content

Abstract

Congenital hemangiomas are benign vascular tumors that are distinct from infantile hemangiomas. Congenital hemangiomas are fully formed at birth and are negative for the glucose 1 transporter (GLUT-1). They can be rapidly involuting, partially involuting, or non-involuting. If non-involuting or partially involuting, treatment is primarily with surgical excision.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Berenguer B, et al. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003;6(6):495–510.

    Article  Google Scholar 

  2. Mulliken JB, Enjolras O. Congenital hemangiomas and infantile hemangioma: missing links. J Am Acad Dermatol. 2004;50(6):875–82.

    Article  Google Scholar 

  3. Nasseri E, et al. Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol. 2014;70(1):75–9.

    Article  Google Scholar 

  4. Funk T, et al. Symptomatic congenital hemangioma and congenital Hemangiomatosis associated with a somatic activating mutation in GNA11. JAMA Dermatol. 2016;152(9):1015–20.

    Article  Google Scholar 

  5. Vildy S, et al. Life-threatening hemorrhaging in neonatal ulcerated congenital hemangioma: two case reports. JAMA Dermatol. 2015;151(4):422–5.

    Article  Google Scholar 

  6. Patrick LM, et al. Rapid involuting congenital hemangioma in the setting of PHACE association. Pediatrics. 2014;133(6):e1777–80.

    Article  Google Scholar 

  7. Gorincour G, et al. Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involuting congenital hemangiomas. Pediatr Radiol. 2005;35(12):1178–85.

    Article  Google Scholar 

  8. Fadell MF 2nd, Jones BV, Adams DM. Prenatal diagnosis and postnatal follow-up of rapidly involuting congenital hemangioma (RICH). Pediatr Radiol. 2011;41(8):1057–60.

    Article  Google Scholar 

  9. Aboutalebi A, et al. Histopathology of vascular anomalies. Facial Plast Surg. 2012;28(6):545–53.

    Article  CAS  Google Scholar 

  10. Al Dhaybi R, et al. Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: evaluation of 126 cases. J Am Acad Dermatol. 2010;63(6):1052–7.

    Article  Google Scholar 

  11. Lee PW, et al. Characteristics of noninvoluting congenital hemangioma: a retrospective review. J Am Acad Dermatol. 2014;70(5):899–903.

    Article  Google Scholar 

  12. North PE, et al. Congenital nonprogressive hemangioma: a distinct clinicopathologic entity unlike infantile hemangioma. Arch Dermatol. 2001;137(12):1607–20.

    Article  CAS  Google Scholar 

  13. Ayturk UM, et al. Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma. Am J Hum Genet. 2016;98(4):789–95.

    Article  CAS  Google Scholar 

  14. Krol A, MacArthur CJ. Congenital hemangiomas: rapidly involuting and noninvoluting congenital hemangiomas. Arch Facial Plast Surg. 2005;7(5):307–11.

    Article  Google Scholar 

  15. Maguiness S, et al. Rapidly involuting congenital hemangioma with fetal involution. Pediatr Dermatol. 2015;32(3):321–6.

    Article  Google Scholar 

  16. Baselga E, et al. Rapidly involuting congenital haemangioma associated with transient thrombocytopenia and coagulopathy: a case series. Br J Dermatol. 2008;158(6):1363–70.

    Article  CAS  Google Scholar 

  17. Rangwala S, et al. Rapidly involuting congenital hemangioma associated with profound, transient thrombocytopenia. Pediatr Dermatol. 2014;31(3):402–4.

    Article  Google Scholar 

  18. Sur A, et al. Multiple successful angioembolizations for refractory cardiac failure in a preterm with rapidly involuting congenital hemangioma. AJP Rep. 2016;6(1):e99–e103.

    Article  Google Scholar 

  19. Browning JC, Metry DW. Rapidly involuting congenital hemangioma: case report and review of the literature. Dermatol Online J. 2008;14(4):11.

    PubMed  Google Scholar 

  20. Boucek RJ Jr, et al. Propranolol responsiveness in vascular tumors is not determined by qualitative differences in adrenergic receptors. Otolaryngol Head Neck Surg. 2013;149(5):772–6.

    Article  Google Scholar 

  21. **Berenguer B, et al. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003;6(6):495–510.

    Article  Google Scholar 

  22. **Nasseri E, et al. Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol. 2014;70(1):75–9.

    Article  Google Scholar 

  23. **Lee PW, et al. Characteristics of noninvoluting congenital hemangioma: a retrospective review. J Am Acad Dermatol. 2014;70(5):899–903.

    Article  Google Scholar 

  24. ***Ayturk UM, et al. Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma. Am J Hum Genet. 2016;98(4):789–95.

    Article  CAS  Google Scholar 

  25. ***Baselga E, et al. Rapidly involuting congenital haemangioma associated with transient thrombocytopenia and coagulopathy: a case series. Br J Dermatol. 2008;158(6):1363–70.

    Article  CAS  Google Scholar 

Download references

To assist the reader in gaining familiarity with available evidence, the following rating system has been used to indicate key references for each chapter’s content:

***: Critical material. Anyone dealing with this condition should be familiar with this reference.

**: Useful material. Important information that is valuable in in clinical or scientific practice related to this condition.

*: Optional material. For readers with a strong interest in the chapter content or a desire to study it in greater depth.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Megha M. Tollefson MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tollefson, M.M. (2018). Congenital Hemangiomas. In: Perkins, J., Balakrishnan, K. (eds) Evidence-Based Management of Head and Neck Vascular Anomalies. Springer, Cham. https://doi.org/10.1007/978-3-319-92306-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-92306-2_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92305-5

  • Online ISBN: 978-3-319-92306-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics