Skip to main content

Colorectal Cancer Screening

  • Living reference work entry
  • First Online:
Geriatric Gastroenterology

Abstract

Colorectal cancer (CRC) is a major contributor to cancer morbidity and mortality in the United States and disproportionately affects the elderly. In parallel, there is a growing group of older patients who have better life expectancy and are high utilizers of CRC screening resources. However, screening in older age groups is not well targeted to individual patients, with evidence of both overutilization and underutilization. While several screening options are available, there are age-dependent specifics to colorectal neoplasia and screening test performance which render colonoscopy the most important test to consider. In older patients, the benefits of early detection and prevention of CRC may be offset by higher risk of procedure-related harm and diminished health and life expectancy. Screening for CRC should ideally be targeted to elderly patients with a life expectancy of at least 10 years. Guidelines recommend individualizing screening in adults aged 76–85 years based on overall health and prior screening history and foregoing screening in those 86 years and older.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Arora A, Singh P. Colonoscopy in patients 80 years of age and older is safe, with high success rate and diagnostic yield. Gastrointest Endosc. 2004;60:408–13.

    Article  PubMed  Google Scholar 

  • Brenner H, Hoffmeister M, Stegmaier C, Brenner G, Altenhofen L, Haug U. Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies. Gut. 2007;56:1585–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cha JM, Kozarek RA, La Selva D, Gluck M, Ross A, Chiorean M, Koch J, Lin OS. Risks and benefits of colonoscopy in patients 90 years or older, compared with younger patients. Clin Gastroenterol Hepatol. 2016;14:80–6 e1.

    Article  PubMed  Google Scholar 

  • Cooper GS, Kou TD, Barnholtz Sloan JS, Koroukian SM, Schluchter MD. Use of colonoscopy for polyp surveillance in medicare beneficiaries. Cancer. 2013;119:1800–7.

    Article  PubMed  Google Scholar 

  • Cucino C, Buchner AM, Sonnenberg A. Continued rightward shift of colorectal cancer. Dis Colon Rectum. 2002;45:1035–40.

    Article  PubMed  Google Scholar 

  • Day LW, Velayos F. Colorectal cancer and the elderly. Clin Geriatr Med. 2014;30:117–31.

    Article  PubMed  Google Scholar 

  • Day LW, Walter LC, Velayos F. Colorectal cancer screening and surveillance in the elderly patient. Am J Gastroenterol. 2011;106:1197–206; quiz 1207

    Article  PubMed  Google Scholar 

  • Duncan JE, Sweeney WB, Trudel JL, Madoff RD, Mellgren AF. Colonoscopy in the elderly: low risk, low yield in asymptomatic patients. Dis Colon Rectum. 2006;49:646–51.

    Article  PubMed  Google Scholar 

  • Feingold DL, Forde KA. Colorectal cancer surveillance after age 65 years. Am J Surg. 2003;185:297–300.

    Article  PubMed  Google Scholar 

  • USPSTF Final Recommendation Statement: Colorectal Cancer: Screening. U.S. Preventive Services Task Force. June 2017. https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/colorectal-cancer-screening2. [Online].

  • Fisher DA, Galanko J, Dudley TK, Shaheen NJ. Impact of comorbidity on colorectal cancer screening in the veterans healthcare system. Clin Gastroenterol Hepatol. 2007;5:991–6.

    Article  PubMed  Google Scholar 

  • Froehlich F, Wietlisbach V, Gonvers JJ, Burnand B, Vader JP. Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc. 2005;61:378–84.

    Article  PubMed  Google Scholar 

  • Goodwin JS, Singh A, Reddy N, Riall TS, Kuo YF. Overuse of screening colonoscopy in the Medicare population. Arch Intern Med. 2011;171:1335–43.

    Article  PubMed  Google Scholar 

  • Gross CP, Mcavay GJ, Krumholz HM, Paltiel AD, Bhasin D, Tinetti ME. The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening. Ann Intern Med. 2006;145:646–53.

    Article  PubMed  Google Scholar 

  • Haggstrom DA, Klabunde CN, Smith JL, Yuan G. Variation in primary care physicians’ colorectal cancer screening recommendations by patient age and comorbidity. J Gen Intern Med. 2013;28:18–24.

    Article  PubMed  Google Scholar 

  • Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, James PD, Mangham CM. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet. 1996;348:1472–7.

    Article  CAS  PubMed  Google Scholar 

  • Harewood GC, Lieberman DA. Colonoscopy practice patterns since introduction of medicare coverage for average-risk screening. Clin Gastroenterol Hepatol. 2004;2:72–7.

    Article  PubMed  Google Scholar 

  • Hoffman RM, Walter LC. Colorectal cancer screening in the elderly: the need for informed decision making. J Gen Intern Med. 2009;24:1336–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • https://www.census.gov/prod/cen2010/briefs/c2010br-09.pdf. [Online].

  • Imperiale TF, Ransohoff DF, Itzkowitz SH. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014;371:187–8.

    CAS  PubMed  Google Scholar 

  • Kahi CJ. Screening relevance of sessile serrated polyps. Clin Endosc. 2019;52:235.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kahi CJ, Azzouz F, Juliar BE, Imperiale TF. Survival of elderly persons undergoing colonoscopy: implications for colorectal cancer screening and surveillance. Gastrointest Endosc. 2007;66:544–50.

    Article  PubMed  Google Scholar 

  • Kahi CJ, Van Ryn M, Juliar B, Stuart JS, Imperiale TF. Provider recommendations for colorectal cancer screening in elderly veterans. J Gen Intern Med. 2009;24:1263–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kahi CJ, Myers LJ, Slaven JE, Haggstrom D, Pohl H, Robertson DJ, Imperiale TF. Lower endoscopy reduces colorectal cancer incidence in older individuals. Gastroenterology. 2014;146:718–725 e3.

    Article  PubMed  Google Scholar 

  • Knudsen AB, Zauber AG, Rutter CM, Naber SK, Doria-Rose VP, Pabiniak C, Johanson C, Fischer SE, Lansdorp-Vogelaar I, Kuntz KM. Estimation of benefits, burden, and harms of colorectal cancer screening strategies: modeling study for the US Preventive Services Task Force. JAMA. 2016;315:2595–609.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ko CW, Sonnenberg A. Comparing risks and benefits of colorectal cancer screening in elderly patients. Gastroenterology. 2005;129:1163–70.

    Article  PubMed  Google Scholar 

  • Koretz RL. Polyp surveillance in patients with limited life expectancy. JAMA. 1996;275:327.

    Article  CAS  PubMed  Google Scholar 

  • Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet. 1996;348:1467–71.

    Article  CAS  PubMed  Google Scholar 

  • Lee SJ, Boscardin WJ, Stijacic-Cenzer I, Conell-Price J, O’Brien S, Walter LC. Time lag to benefit after screening for breast and colorectal cancer: meta-analysis of survival data from the United States, Sweden, United Kingdom, and Denmark. BMJ. 2013;346:e8441.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lewis CL, Griffith J, Pignone MP, Golin C. Physicians’ decisions about continuing or stopping colon cancer screening in the elderly: a qualitative study. J Gen Intern Med. 2009;24:816–21.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lieberman DA, Williams JL, Holub JL, Morris CD, Logan JR, Eisen GM, Carney P. Colonoscopy utilization and outcomes 2000 to 2011. Gastrointest Endosc. 2014;80:133–43.

    Article  PubMed  Google Scholar 

  • Lin OS, Kozarek RA, Schembre DB, Ayub K, Gluck M, Drennan F, Soon MS, Rabeneck L. Screening colonoscopy in very elderly patients: prevalence of neoplasia and estimated impact on life expectancy. JAMA. 2006;295:2357–65.

    Article  CAS  PubMed  Google Scholar 

  • Lin JS, Piper MA, Perdue LA, Rutter CM, Webber EM, O’Connor E, Smith N, Whitlock EP. Screening for colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2016;315:2576–94.

    Article  CAS  PubMed  Google Scholar 

  • Lukens FJ, Loeb DS, Machicao VI, Achem SR, Picco MF. Colonoscopy in octogenarians: a prospective outpatient study. Am J Gastroenterol. 2002;97:1722–5.

    Article  PubMed  Google Scholar 

  • Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, Ederer F. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328:1365–71.

    Article  CAS  PubMed  Google Scholar 

  • Miller KM, Waye JD. Approach to colon polyps in the elderly. Am J Gastroenterol. 2000;95:1147–51.

    Article  CAS  PubMed  Google Scholar 

  • Miller K, Waye JD. Colorectal polyps in the elderly: what should be done? Drugs Aging. 2002;19:393–404.

    Article  PubMed  Google Scholar 

  • Miyakura Y, Sugano K, Konishi F, Ichikawa A, Maekawa M, Shitoh K, Igarashi S, Kotake K, KOYAMA Y, NAGAI H. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology. 2001;121:1300–9.

    Article  CAS  PubMed  Google Scholar 

  • Murphy CC, Sandler RS, Grubber JM, Johnson MR, Fisher DA. Underuse and overuse of colonoscopy for repeat screening and surveillance in the Veterans Health Administration. Clin Gastroenterol Hepatol. 2016;14:436–444 e1.

    Article  PubMed  Google Scholar 

  • Ransohoff DF, Lang CA. Sigmoidoscopic screening in the 1990s. JAMA. 1993;269:1278–81.

    Article  CAS  PubMed  Google Scholar 

  • Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW, Goldblum JR, Guillem JG, Kahi CJ, Kalady MF, O’BRIEN MJ, Odze RD, Ogino S, Parry S, Snover DC, Torlakovic EE, Wise PE, Young J, Church J. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol. 2012;107:1315–29; quiz 1314, 1330

    Article  PubMed  PubMed Central  Google Scholar 

  • Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal cancer screening: recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017;153:307–23.

    Article  PubMed  Google Scholar 

  • Schoenborn NL, Lee K, Pollack CE, Armacost K, Dy SM, Bridges JFP, Xue QL, Wolff AC, Boyd C. Older adults’ views and communication preferences about cancer screening cessation. JAMA Intern Med. 2017;177:1121–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sheffield KM, Han Y, Kuo YF, Riall TS, Goodwin JS. Potentially inappropriate screening colonoscopy in Medicare patients: variation by physician and geographic region. JAMA Intern Med. 2013;173:542–50.

    Article  PubMed  Google Scholar 

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.

    Article  PubMed  Google Scholar 

  • Stevens T, Burke CA. Colonoscopy screening in the elderly: when to stop? Am J Gastroenterol. 2003;98:1881–5.

    Article  PubMed  Google Scholar 

  • Tang V, Boscardin WJ, Stijacic-Cenzer I, Lee SJ. Time to benefit for colorectal cancer screening: survival meta-analysis of flexible sigmoidoscopy trials. BMJ. 2015;350:h1662.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tran AH, Man Ngor EW, Wu BU. Surveillance colonoscopy in elderly patients: a retrospective cohort study. JAMA Intern Med. 2014;174:1675–82.

    Article  PubMed  Google Scholar 

  • U.S. Census Bureau, Statistical Abstract of the United States: 2012.

    Google Scholar 

  • Van Hees F, Habbema JD, Meester RG, Lansdorp-Vogelaar I, VAN Ballegooijen M, Zauber AG. Should colorectal cancer screening be considered in elderly persons without previous screening? A cost-effectiveness analysis. Ann Intern Med. 2014;160:750–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Walter LC, Covinsky KE. Cancer screening in elderly patients: a framework for individualized decision making. JAMA. 2001;285:2750–6.

    Article  CAS  PubMed  Google Scholar 

  • Walter LC, Lewis CL, Barton MB. Screening for colorectal, breast, and cervical cancer in the elderly: a review of the evidence. Am J Med. 2005;118:1078–86.

    Article  PubMed  Google Scholar 

  • Walter LC, Lindquist K, Nugent S, Schult T, Lee SJ, Casadei MA, Partin MR. Impact of age and comorbidity on colorectal cancer screening among older veterans. Ann Intern Med. 2009;150:465–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • Warren JL, Klabunde CN, Mariotto AB, Meekins A, Topor M, Brown ML, Ransohoff DF. Adverse events after outpatient colonoscopy in the Medicare population. Ann Intern Med. 2009;150:849–57, W152

    Article  PubMed  Google Scholar 

  • Winawer SJ, Zauber AG, Ho MN, O’Brien MJ, Gottlieb LS, Sternberg SS, Waye JD, Schapiro M, Bond JH, Panish JF, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med. 1993;329:1977–81.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Charles J. Kahi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kahi, C.J., Rex, D.K. (2020). Colorectal Cancer Screening. In: Pitchumoni, C., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-90761-1_75-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-90761-1_75-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90761-1

  • Online ISBN: 978-3-319-90761-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics