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Continued Rightward Shift of Colorectal Cancer

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

Abstract

PURPOSE: Previous analyses of the time trends of colorectal cancer have suggested a shift from left-sided toward right-sided cancer sites. The aim of this study was to determine whether such trends in the subsite distribution of colorectal cancer could be confirmed in hospitalization statistics similarly as in the incidence data. METHODS: The inpatient files of the Department of Veterans Affairs and the Surveillance, Epidemiology, and End Result database of the National Cancer Institute were used to study the time trends of colorectal cancer in the United States during the past three decades. Any cancer location in the rectum, sigmoid, or descending colon was defined as left-sided colorectum. RESULTS: For the period between 1970 and 2000, the data from the Department of Veterans Affairs revealed a statistically significant 16 percent increase in the proportion of proximal lesions among white males and females, as well as a 22 percent increase in black males. For the period between 1973 and 1997, the data from the Surveillance, Epidemiology, and End Result revealed a 6 percent increase in the proportion of proximal colon cancers among whites and blacks of both genders. CONCLUSIONS: The epidemiologic data confirm a rightward shift in the colonic distribution of cancer.

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References

  1. RT Greenlee MB Hill-Harmon T Murray M Thun (2001) ArticleTitleCancer statistics 2001 CA Cancer J Clin 51 15–36

    Google Scholar 

  2. LM Axtell L Chiazze SuffixJr (1966) ArticleTitleChanging relative frequency of cancers of the colon and rectum in the United States Cancer 19 250–254

    Google Scholar 

  3. JB Rhodes FF Holmes GM Clark (1977) ArticleTitleChanging distribution of primary cancers in the large bowel JAMA 238 1641–1643

    Google Scholar 

  4. JS Abrams HD Reines (1979) ArticleTitleIncreasing incidence of right-sided lesions in colorectal cancer Am J Surg 137 522–526

    Google Scholar 

  5. J Mamazza PH Gordon (1982) ArticleTitleThe changing distribution of large intestinal cancer Dis Colon Rectum 25 558–562

    Google Scholar 

  6. G Slater AE Papatestas PI Tartter M Mulvihill AH Aufses SuffixJr (1982) ArticleTitleAge distribution of right- and left-sided colorectal cancers Am J Gastroenterol 77 63–66

    Google Scholar 

  7. RW Beart SuffixJr LJ Melton SuffixIII M Maruta MB Dockerty HB Frydenberg WM O’Fallon (1983) ArticleTitleTrends in right and left-sided colon cancer Dis Colon Rectum 26 393–398

    Google Scholar 

  8. J Vobecky C Leduc G Devroede (1984) ArticleTitleSex differences in the changing anatomic distribution of colorectal carcinoma Cancer 54 3065–3069

    Google Scholar 

  9. D Butcher K Hassanein M Dudgeon J Rhodes FF Holmes (1985) ArticleTitleFemale gender is a major determinant of changing subsite distribution of colorectal cancer with age Cancer 56 714–716

    Google Scholar 

  10. R Schub FU Steinheber (1986) ArticleTitleRightward shift of colon cancer. A feature of the aging gut J Clin Gastroenterol 8 630–634

    Google Scholar 

  11. PM Griffin JM Liff RS Greenberg WS Clark (1991) ArticleTitleAdenocarcinoma of the colon and rectum in persons under 40 years old. A population based study Gastroenterology 100 1033–1040

    Google Scholar 

  12. JR Jass (1991) ArticleTitleSubsite distribution and incidence of colorectal cancer in New Zealand, 1974–1983 Dis Colon Rectum 34 56–59

    Google Scholar 

  13. F Kee RH Wilson R Gilliland JM Sloan BJ Rowlands RJ Moorehead (1992) ArticleTitleChanging site in the distribution of colorectal cancer BMJ 305 158–59

    Google Scholar 

  14. F Levi L Randimbison C La Vecchia (1993) ArticleTitleTrends in subsite distribution of colorectal cancers and polyps from the Vaud Cancer Registry Cancer 72 46–50

    Google Scholar 

  15. R Loffeld A Putten A Balk (1996) ArticleTitleChanges in the localization of colorectal cancer J Gastroenterol Hepatol 11 47–50

    Google Scholar 

  16. RY Demers RK Severson D Schottenfeld L Lazar (1997) ArticleTitleIncidence of colorectal adenocarcinoma by anatomic subsite. An epidemiologic study of time trends and racial differences in the Detroit, Michigan area Cancer 79 441–447

    Google Scholar 

  17. BT Ji SS Devesa WH Chow F Jin YT Gao (1998) ArticleTitleColorectal cancer incidence trends by subsite in urban Shangai, 1972–1994 Cancer Epidemiol Biomarkers Prev 7 661–666

    Google Scholar 

  18. C Bonithon-Kopp AM Benhamiche (1999) ArticleTitleAre there several colorectal cancers? Epidemiological data Eur J Cancer Prev 8 3–12

    Google Scholar 

  19. A Miller M Gorska M Bassett (2000) ArticleTitleProximal shift of colorectal cancer in the Australian Capital Territory over 20 years Aust N Z J Med 30 221–225

    Google Scholar 

  20. PH Chapuis RC Newland JG Macpherson O Dent JE Payne MT Pheils (1981) ArticleTitleThe distribution of colorectal carcinoma and the relationship of tumour site to the survival of patients following resection Aust N Z J Surg 51 127–131

    Google Scholar 

  21. S Crerand TM Feeley RP Waldron et al. (1991) ArticleTitleColorectal carcinoma over 30 years at one hospital Int J Colorect Dis 6 184–187

    Google Scholar 

  22. J Huang A Seow CY Shi HP Lee (1999) ArticleTitleColorectal carcinoma among ethnic Chinese in Singapore Cancer 85 2519–2525

    Google Scholar 

  23. VK Sharma R Vasudeva CW Howden (2000) ArticleTitleChanges in colorectal cancer over a 15-year period in a single United States city Am J Gastroenterol 85 3615–3619

    Google Scholar 

  26. M Ponz De Leon C Sacchetti R Sassatelli G Zanghieri L Roncucci A Scalmati (1990) ArticleTitleEvidence for the existence of different types of large bowel tumor J Surg Oncol 44 35–43

    Google Scholar 

  27. DW West ML Slattery LM Robison et al. (1989) ArticleTitleDietary intake and colon cancer Am J Epidemiol 130 883–894

    Google Scholar 

  28. JD Potter ML Slattery RM Bostick SM Gapstur (1993) ArticleTitleColon cancer Epidemiol Rev 16 499–545

    Google Scholar 

  29. Y Miyakura K Sugano F Konishi et al. (2001) ArticleTitleExtensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability Gastroenterology 121 1300–1309

    Google Scholar 

  30. PA Newcomb RG Norfleet BE Storer TS Surawicz PM Marcus (1992) ArticleTitleScreening sigmoidoscopy and colorectal cancer mortality J Natl Cancer Inst 84 1572–1575

    Google Scholar 

  31. JV Selby GD Friedman CP Quesenberry NS Weiss (1992) ArticleTitleA case-control study of screening sigmoidoscopy and mortality from colorectal cancer N Engl J Med 326 653–657

    Google Scholar 

Download references

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Authors and Affiliations

    Authors
    1. Claudia Cucino M.D.
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    2. Anna M. Buchner M.D., Ph.D.
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    3. Amnon Sonnenberg M.D., M.Sc.
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    Cucino, C., Buchner, A.M. & Sonnenberg, A. Continued Rightward Shift of Colorectal Cancer. Dis Colon Rectum 45, 1035–1040 (2002). https://doi.org/10.1007/s10350-004-6356-0

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