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The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging

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Stem Cell Genetics for Biomedical Research

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Abstract

Aging is a process characterized by several alterations, such as accumulation of macromolecular damage, genomic instability, and loss of heterochromatin, which leads to a decline in stem cell function and reduced regenerative capacity. Recently, reprogramming of aged cells has been achieved, which illustrates the reversible potential of aging and evokes the idea of rejuvenation. In this chapter, we summarize the main advances in the field of reprogramming in aging, both in vitro and in vivo, which have contributed to further understand the molecular mechanisms underlying physiological and pathological aging. We also describe candidate therapeutic strategies that demolish age-associated reprogramming barriers and alleviate normal and premature aging.

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Acknowledgments

This work was supported by grants from European Union (DeAge, ERC Advanced Grant), Ministerio de Economía y Competitividad, Instituto de Salud Carlos III; CIBERONC, Plan Feder, and EDP Foundation. We also thank the generous support by J. I. Cabrera and Associazione Italiana Progeria Sammy Basso. The Instituto Universitario de Oncología is supported by Fundación Bancaria Caja de Ahorros de Asturias.

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  1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain

    Dido Carrero & Carlos López-Otín

  2. Centro de Investigación en Red de Cáncer, Madrid, Spain

    Carlos López-Otín

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  1. Dido Carrero
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Correspondence to Carlos López-Otín .

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  1. Duran i Reynals Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Raul Delgado-Morales

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Carrero, D., López-Otín, C. (2018). The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging. In: Delgado-Morales, R. (eds) Stem Cell Genetics for Biomedical Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90695-9_13

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