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Heat Shock Proteins in Cardiovascular Diseases: From Bench to Bedside

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

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Abstract

Heat shock proteins (HSP) are stress proteins induced in response to a wide variety of physiological and environmental insults. HSP function as molecular chaperones and they are required to maintain the proteome in a folded and functional state, allowing the cells to survive stress conditions. These key proteins, which may be located intracellularly or extracellularly, have multiple functions that range from the regulation of essential cells function to the renaturation of misfolded proteins. In the last decades, the HSP involvement in both normal cell function and disease pathogenesis is widely studied, especially in the context of cardiovascular diseases (CVDs). This chapter covers the current knowledge on the function HSP in the cardiovascular system and particular in the relationship between these proteins and CVDs. Initially, the roles of HSP in cardiovascular health are outlined, followed by an evaluation of the role of HSP in CVDs key processes, such as atherosclerosis, vascular hypertrophy and heart failure. Finally, the therapeutic potential of roles HSP are examined in a CVDs context, considering how the knowledge actually gained may be capitalized in future clinical studies.

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Abbreviations

AIF:

apoptosis inducing factor

ApoE-/- :

apolipoproteinE knock out mice

Ca2+ :

calcium

CEL:

celastrol

CVDs:

cardiovascular diseases

GGA:

geranylgeranylacetone

HSEs:

heat shock elements

Hsf1:

heat transcription factor 1

HSP:

heat shock protein

LDL-C:

low-density lipoprotein-cholesterol

RIPC:

remote ischemic preconditioning

ROS:

reactive oxygen species

sHSP:

small heat shock protein

sHSP60:

soluble heat shock protein60

SMCs:

smooth muscle cells

TLR4s:

toll-like receptors 4

VSMCs:

vascular smooth muscle cells

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Acknowledgements

This study was supported by the grant (ex-60%) of the University of Brescia, Italy. The Authors sincerely thanks also Fondazione Cariplo e Regione Lombardia “New opportunities and ways towards ERC” (Project 2014-2256).

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Authors and Affiliations

  1. Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

    Francesca Bonomini, Gaia Favero, Valentina Trapletti & Rita Rezzani

  2. Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs- (ARTO)”, University of Brescia, Brescia, Italy

    Francesca Bonomini & Rita Rezzani

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  1. Francesca Bonomini
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Correspondence to Rita Rezzani .

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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Bonomini, F., Favero, G., Trapletti, V., Rezzani, R. (2018). Heat Shock Proteins in Cardiovascular Diseases: From Bench to Bedside. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_11

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