Abstract
Bleeding disorders with low plasma activity of more than one coagulation factor have been described in several conditions. Multiple coagulation factor deficiency (MCFD) commonly represents as part of acquired conditions. The most well-known acquired causes are liver disease and disseminated intravascular coagulation (DIC) in which impaired synthesis or excessive consumption of coagulation factors occurs, respectively. Dilution states such as massive transfusion and cardiopulmonary bypass are also considered as conditions which lead to MCFD. Congenital deficiencies of more than one coagulation factor rarely have been also described. Such disorders can be rare autosomal bleeding disorder with extremely low incidence. Congenital MCFD may arise from coinheritance of isolated factor defects or may be a result of a single genetic defect. The latter which comprises most of cases is generally caused by defect of a single gene that is implicated in the process or production/activation of multiple factors. The best examples include combined FV and FVIII deficiency (F5F8D) and vitamin K-dependent coagulation factors (VKDCF) deficiency, which have been thoroughly characterized. Isolated combined coagulation factor deficiencies are extremely rare disorders and restricted to isolated case reports.
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Hosseini, M.S., Shams, M., Dorgalaleh, A., Mansouritorghabeh, H. (2018). Multiple Coagulation Factor Deficiency. In: Dorgalaleh, A. (eds) Congenital Bleeding Disorders . Springer, Cham. https://doi.org/10.1007/978-3-319-76723-9_9
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