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Deficiency of coagulation factors VII and X associated with deletion of a chromosome 13 (q34). Evidence from two cases with 46,XY,t(13;Y)(q11;q34)

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Summary

Deficiency of coagulation factors VII and X was found in two patients (Erlangen and Nancy) who shared the same chromosomal aberration 46,XY,t(13;Y)(q11;q34) with probable loss of a terminal segment of 13q. Loci involved in synthesis or constitution of these factors may be located at 13 (q34).

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Authors and Affiliations

  1. Institut für Humangenetik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Bismarckstr. 10, D-8520, Erlangen, Federal Republic of Germany

    R. A. Pfeiffer

  2. Universitäts-Kinderklinik, Loschgestr. 15, D-8520, Erlangen, Federal Republic of Germany

    R. Ott

  3. Centre Regional de Transfusion Sanguine et d'Hematologie de Nancy, Ave de Bourgogne, F-54511, Vandoeuvre-les-Nancy, France

    S. Gilgenkrantz

  4. Centre Regional de Transfusion Sanguine et d'Hematologie de Nancy, 9-11 Rue Lionnois, F-54000, Nancy, France

    P. Alexandre

Authors
  1. R. A. Pfeiffer
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  2. R. Ott
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  3. S. Gilgenkrantz
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  4. P. Alexandre
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Additional information

The paper is dedicated to Prof. Dr. G. Koch on the occasion of his 70th birthday

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Pfeiffer, R.A., Ott, R., Gilgenkrantz, S. et al. Deficiency of coagulation factors VII and X associated with deletion of a chromosome 13 (q34). Evidence from two cases with 46,XY,t(13;Y)(q11;q34). Hum Genet 62, 358–360 (1982). https://doi.org/10.1007/BF00304557

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  • DOI: https://doi.org/10.1007/BF00304557

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