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Connective Tissue Disorders

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Aortic Regurgitation

Abstract

Heritable connective tissue diseases comprise a heterogeneous group of multi-systemic disorders that result from genetic defects affecting normal extracellular matrix (ECM) assembly and maintenance. The connective tissue is a tissue structure which represents a three-dimensional thread. The three main functions of connective tissues are support, protection, and nutrition of other tissues. It is mainly the support function which is affected in pathologies discussed in this chapter. Connective tissues are composed of cells, fibres, and ground substance (the latter two make up the ECM). There are many different types of connective tissues. Pathologies affecting vascular wall connective tissue are discussed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada

    Marie-Catherine Morgant M.D.

  2. Department of Cardiac Surgery, Aortic and Connective Tissue Clinic, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada

    Ismail El-Hamamsy M.D., Ph.D., F.R.C.S.C.

Authors
  1. Marie-Catherine Morgant M.D.
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  2. Ismail El-Hamamsy M.D., Ph.D., F.R.C.S.C.
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Corresponding author

Correspondence to Ismail El-Hamamsy M.D., Ph.D., F.R.C.S.C. .

Editor information

Editors and Affiliations

  1. Department of Cardiac Surgery, Charles University in Prague, Hradec Kralove, Czech Republic

    Jan Vojacek

  2. Department of Cardiac Surgery, Charles University in Prague, Hradec Kralove, Czech Republic

    Pavel Zacek

  3. Department of Cardiac Surgery, Charles University in Prague, Hradec Kralove, Czech Republic

    Jan Dominik

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Morgant, MC., El-Hamamsy, I. (2018). Connective Tissue Disorders. In: Vojacek, J., Zacek, P., Dominik, J. (eds) Aortic Regurgitation. Springer, Cham. https://doi.org/10.1007/978-3-319-74213-7_9

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  • DOI: https://doi.org/10.1007/978-3-319-74213-7_9

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