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Notch Signaling in Lung Cancer Initiation and Development

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Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs

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Abstract

Cancer stem cells (CSCs), or tumorigenic cancer cells, are termed as a small proportion of tumor cells that are responsible for cancer differentiation, initiation, development and drug resistance. Accumulating evidence has shown a wide range of cancers, such as lung cancer, is initiated from CSCs. Understanding the tumorigenic mechanisms of CSCs is one of the most pressing problems in modern biology. The Notch signaling pathway is characterized as one of the three core stem cell signaling pathways and plays an instrumental role in activating mutations and amplifications in lung cancer. In this chapter, we will briefly review the experimental model and clinical progress in lung cancer stem cell research and discuss the therapeutically potential target of Notch signaling in lung cancer stem cell research.

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Author notes

  1. Kayla C. Lewis and Yi Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA

    Kayla C. Lewis & Yi Liu

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  1. Kayla C. Lewis
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  2. Yi Liu
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Correspondence to Yi Liu .

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Editors and Affiliations

  1. Department of Biochemistry, Rashid Latif Medical College (RLMC), Lahore, Pakistan

    Sundas Fayyaz

  2. Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    Ammad Ahmad Farooqi

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Lewis, K.C., Liu, Y. (2018). Notch Signaling in Lung Cancer Initiation and Development. In: Fayyaz, S., Farooqi, A. (eds) Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Springer, Cham. https://doi.org/10.1007/978-3-319-71553-7_8

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