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The Role of Androgen Excess in Metabolic Dysfunction in Women

Androgen Excess and Female Metabolic Dysfunction

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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1043))

Abstract

Polycystic ovary syndrome (PCOS) is characterized by the association of androgen excess with chronic oligoovulation and/or polycystic ovarian morphology, yet metabolic disorders and classic and nonclassic cardiovascular risk factors cluster in these women from very early in life. This chapter focuses on the mechanisms underlying the association of PCOS with metabolic dysfunction, focusing on the role of androgen excess on the development of visceral adiposity and adipose tissue dysfunction.

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Acknowledgments

Supported by grants PI110357, PI11/00357, and PIE16/00050 and CIBER Diabetes y Enfermedades Metabólicas Asociadas CB07/08/0005, from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Spain. Supported in part by Fondo Europeo de Desarrollo Regional FEDER.

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Authors and Affiliations

  1. Diabetes Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain

    Héctor F. Escobar-Morreale

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  1. Héctor F. Escobar-Morreale
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Correspondence to Héctor F. Escobar-Morreale .

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  1. Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA

    Franck Mauvais-Jarvis

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Escobar-Morreale, H.F. (2017). The Role of Androgen Excess in Metabolic Dysfunction in Women. In: Mauvais-Jarvis, F. (eds) Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Advances in Experimental Medicine and Biology, vol 1043. Springer, Cham. https://doi.org/10.1007/978-3-319-70178-3_26

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