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Colostrum Proteomics Research: A Complex Fluid with Multiple Physiological Functions

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Proteomics in Domestic Animals: from Farm to Systems Biology

Abstract

This chapter addresses several aspects related to colostrum, from its synthesis in the mammary gland to the absorption of the colostrum components by the newborn and its effects on the maturation of the immune and digestive system. This chapter also describes the different colostrum fractions, considering high and low abundant proteins. Additionally, the function of those proteins and their role on the passive immune transfer and nutrition in the newborn animal are also included. Finally, it will be described how different proteomics tools have been utilized in order to answer questions about colostrum associated immunology and nutrition in newborn ungulates.

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Abbreviations

Igs:

Immunoglobulins

MS:

Mass spectrometry

MALDI:

Matrix-assisted laser desorption/ionization

TOF:

Time of flight

iTRAQ:

Isobaric tag for relative and absolute quantitation

MFGM:

Milk fat globule membrane

PIT:

Passive immune transfer

TJ:

Tight junctions

FcRn:

Fc receptor of the neonate

IgG:

Immunoglobulin G

SCNT:

Somatic cell nuclear transfer

UPLC:

Ultra performance liquid chromatography

LTQ:

Linear trap quadrupole

SLS:

Small litter size

LLS:

Large litter size

BTF3:

Basic transcription factor 3

MCM3:

Minichromosome maintenance complex component 3

FABPs:

Fatty acid-binding proteins

HSPs:

Heat stress proteins

DIGE:

Difference gel electrophoresis

APP:

Acute-phase proteins

PGF:

Placental growth factor

TNF-α:

Tumor necrosis factor alpha

TNF-β:

Tumor necrosis factor beta

VEGF:

Vascular endothelial growth factor

HAP:

High abundant proteins

LAP:

Low abundant proteins

IGF-1:

Insulin-like growth factor-1

EGF:

Epidermal growth factor-like peptide

2DE:

Two-dimensional electrophoresis

XDH/XO:

Xanthine dehydrogenase/oxidase

C3:

Complement component 3

LBP:

Lipopolysaccharide-binding protein

FN1:

Fibrinectin 1

SAA:

Serum amyloid A

APO:

Apolipoproteins

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Authors and Affiliations

  1. Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

    Lorenzo E. Hernández-Castellano, Josef Gross, Olga Wellnitz & Rupert M. Bruckmaier

  2. Faculty of Science and Technology, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Lorenzo E. Hernández-Castellano

  3. Department of Animal Science, Pennsylvania State University, PA, University Park, USA

    Craig R. Baumrucker

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  1. Lorenzo E. Hernández-Castellano
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  5. Rupert M. Bruckmaier
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Correspondence to Lorenzo E. Hernández-Castellano .

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Editors and Affiliations

  1. Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisbon, Portugal

    Andre Martinho de Almeida

  2. ERA Chair Laboratory, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia

    David Eckersall

  3. Institute of Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria

    Ingrid Miller

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Hernández-Castellano, L.E., Baumrucker, C.R., Gross, J., Wellnitz, O., Bruckmaier, R.M. (2018). Colostrum Proteomics Research: A Complex Fluid with Multiple Physiological Functions. In: de Almeida, A., Eckersall, D., Miller, I. (eds) Proteomics in Domestic Animals: from Farm to Systems Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-69682-9_8

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