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Clinical Pharmacology of Tinnitus: Design and Evaluation

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Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Abstract

Tinnitus – the perception of phantom sound – is estimated to seriously affect the quality of life of about 3% of the entire world population, making it an attractive target for pharmacotherapy. However, none of the so far conducted clinical trials with the use of pharmacological substances could be called a thrilling success. There are multiple reasons for this, which are discussed in this chapter. Moreover, a comprehensive overview of factors that should be taken under consideration when designing clinical pharmacological study for tinnitus is presented in an anticipation to help design trials producing meaningful clinical data and identifying clinically relevant substances effective in tinnitus treatment.

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Author information

Authors and Affiliations

  1. Department of ORL, Head and Neck Surgery, Charité University Hospital, Berlin, Germany

    Agnieszka J. Szczepek

Authors
  1. Agnieszka J. Szczepek
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Correspondence to Agnieszka J. Szczepek .

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Editors and Affiliations

  1. CorDynamics, Dieburg, Germany

    Franz J. Hock

  2. CorDynamics, Chicago, IL, USA

    Michael R. Gralinski

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Szczepek, A.J. (2020). Clinical Pharmacology of Tinnitus: Design and Evaluation. In: Hock, F., Gralinski, M. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-68864-0_61

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